Comparison of two published definitions of sputum neutrophilia show clinical measures of disease are more severe in neutrophilic asthma (NA) than non-neutrophilic asthma (NNA) using >40% sputum neutrophils as the definition of disease.

C. Barber (Southampton, United Kingdom), J. Ward (Southampton, United Kingdom), S. Elliott (Portsmouth, United Kingdom), L. Lau (Southampton, United Kingdom), A. Azim (Southampton, United Kingdom), K. Gove (Southampton, United Kingdom), H. Rupani (Portsmouth, United Kingdom), T. Brown (Portsmouth, United Kingdom), A. Chauhan (Portsmouth, United Kingdom), K. Staples (Southampton, United Kingdom), P. Howarth (Southampton, United Kingdom)

Source: Virtual Congress 2020 – Phenotypes of obstructive diseases

Session: Phenotypes of obstructive diseases
Session type: E-poster session
Number: 1255

Disease area: Airway diseases

Rating:

You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Barber (Southampton, United Kingdom), J. Ward (Southampton, United Kingdom), S. Elliott (Portsmouth, United Kingdom), L. Lau (Southampton, United Kingdom), A. Azim (Southampton, United Kingdom), K. Gove (Southampton, United Kingdom), H. Rupani (Portsmouth, United Kingdom), T. Brown (Portsmouth, United Kingdom), A. Chauhan (Portsmouth, United Kingdom), K. Staples (Southampton, United Kingdom), P. Howarth (Southampton, United Kingdom). Comparison of two published definitions of sputum neutrophilia show clinical measures of disease are more severe in neutrophilic asthma (NA) than non-neutrophilic asthma (NNA) using >40% sputum neutrophils as the definition of disease.. 1255

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.

You must Login to comment this presentation.

Related content which might interest you:

Inflammatory subtypes in cough variant asthma (CVA): assessment using induced sputum Source: Annual Congress 2007 - Asthma subphenotypes Year: 2007
Exacerbations in the subpopulations and intermediate outcome measures in COPD study (SPIROMICS, NHLBI) are associated with sputum eosinophilia but not blood eosinophilia Source: International Congress 2016 – What's new in biomarker analysis? Year: 2016
A comparison of clinical characteristics between cough variant asthma (CVA) and bronchial asthma (BA) in adult patients Source: Annual Congress 2010 - Asthma aspect of diagnosis and criteria for follow-up Year: 2010
Airway eosinophilia is not related to clinical and functional findings in a large group of severe refractory asthmatics Source: Annual Congress 2006 - Monitoring airway inflammation – exhaled markers vs induced sputum Year: 2006
Eosinophilic inflammation in sputum of poorly controlled asthmatics Source: Eur Respir J 2002; 20: 1370-1377 Year: 2002
Neutrophil elastase levels in sputum of patients with different airway diseases: COPD, bronchiectasis and asthma Source: Eur Respir J 2002; 20: Suppl. 38, 95s Year: 2002
Sputum analysis reveals eosinophilic inflammation in difficult-to-control asthma patients with low blood eosinophils and FENO. Source: Virtual Congress 2020 – Monoclonal antibodies; randomised controlled trials and real-world studies in asthma Year: 2020
Blood eosinophil (EOS) count, exacerbation rate and response to roflumilast in patients with severe COPD Source: International Congress 2017 – What is new in COPD management and prognosis: findings from large studies? Year: 2017
Lung function and sputum neutrophil changes in an experimental model of virus-induced COPD exacerbations Source: Annual Congress 2005 - COPD: role of infection Year: 2005
Reduced eosinophil apoptosis in induced sputum correlates with asthma severity Source: Eur Respir J 2003; 22: 484-490 Year: 2003
Microbiological features of the indicators of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) during remission Source: International Congress 2019 – Clinical aspects of airway diseases Year: 2019
Evaluation of FeNo measurement as an alternative to sputum eosinophils in a severe asthma population Source: International Congress 2017 – Biomarker-based asthma control Year: 2017
Accuracy of blood eosinophil count in predicting sputum eosinophils in children with problematic severe asthma (PSA) Source: Virtual Congress 2020 – Novel mechanisms and management of paediatric asthma Year: 2020
The difference between surfactant protein D (SPD) and C-reactive protein (CRP) levels in patients (pts) with chronic obstructive pulmonary disease acute exacerbations (AE COPD) and community acquired pneumonia (CAP) Source: International Congress 2014 – Clinical presentations Year: 2014
Can blood eosinophils predict sputum eosinophils in stable COPD? Source: International Congress 2015 – Non-exhaled biomarkers in the assessment of airways disease Year: 2015
FE_NO and blood eosinophil count as surrogate barkers of eosinophilic airway inflammation in patients with severe asthma Source: Annual Congress 2010 - Induced sputum in relation: a fresh look on phenotyping and monitoring Year: 2010
Induced sputum and blood T lymphocyte activation during exacerbations of severe asthmatics: the ISEA study Source: Annual Congress 2006 - Towards understanding the pathogenesis of asthma Year: 2006
Pharmacodynamic effect of benralizumab on blood basophils and serum biomarkers in adults with COPD with sputum eosinophilia Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD Year: 2015
Regulation of PMN apoptosis in the airways during community acquired pneumonia in COPD patients and controls Source: Annual Congress 2006 - Molecular airway biology Year: 2006
Clinical evaluation of a new inhibitor of neutrophilic inflammation, tetomilast (OPC-6535), in chronic obstructive pulmonary disease (COPD) Source: Eur Respir J 2006; 28: Suppl. 50, 527s Year: 2006