ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19

Janice M. Leung, Chen X. Yang, Anthony Tam, Tawimas Shaipanich, Tillie-Louise Hackett, Gurpreet K. Singhera, Delbert R. Dorscheid, Don D. Sin

Source: Eur Respir J, 55 (5) 2000688; 10.1183/13993003.00688-2020
Journal Issue: May
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Janice M. Leung, Chen X. Yang, Anthony Tam, Tawimas Shaipanich, Tillie-Louise Hackett, Gurpreet K. Singhera, Delbert R. Dorscheid, Don D. Sin. ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19. Eur Respir J, 55 (5) 2000688; 10.1183/13993003.00688-2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects
Source: Eur Respir J, 56 (2) 2002378; 10.1183/13993003.02378-2020
Year: 2020



MUC5AC and MUC5B expression in central airways from non-smokers, smokers with normal lung function and GOLD stage 1 and 2 COPD patients
Source: Eur Respir J 2006; 28: Suppl. 50, 663s
Year: 2006

Expression of versican in large and small airways and parenchyma in lungs of non-smokers, smokers and COPD patients
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Bronchial airway expression of mucin-related, ENaC and chloride channel genes in COPD and non-COPD smokers compared to former and never smokers
Source: Virtual Congress 2020 – Inflammatory pathways in chronic airway diseases
Year: 2020


Increased expression of aquaporin 5 in bronchial glands of smokers with or without COPD
Source: Annual Congress 2010 - Cell biology and immunology of lung disease
Year: 2010


Enhanced T cell growth from bronchial biopsies of COPD ex-smokers and severe asthmatic subjects compared to COPD current smokers
Source: Eur Respir J 2004; 24: Suppl. 48, 39s
Year: 2004

Pathology of small airways in non-COPD smokers with low diffusion capacity and patients with COPD
Source: Virtual Congress 2020 – Phenotypes of obstructive diseases
Year: 2020


Alterations of the soluble proteome of airway epithelial cells in COPD
Source: Annual Congress 2013 –New strategies in epigenomic research to study lung diseases (DNA rearrangements, RNA, methylation, proteosome)
Year: 2013

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD
Source: Eur Respir J 2002; 20: 556-563
Year: 2002



Expression and release of interleukin-8 by human bronchial epithelial cells from patients with chronic obstructive pulmonary disease, smokers and healthy controls
Source: Eur Respir J 2001; 18: Suppl. 33, 520s
Year: 2001

The clinical importance of small airway involvement in patients with asthma and COPD
Source: International Congress 2019 – PG12 Recent advances in small airways diseases in patients with asthma and COPD
Year: 2019


Different role of p21 in the remodelling of central and peripheral airway epithelium in smokers with and without COPD
Source: Annual Congress 2010 - Novel insights into the pathophysiology of asthma and COPD
Year: 2010

COPD bronchial brush microbiome association with lung function and bronchial gene expression
Source: Virtual Congress 2020 – Host-microbe interactions and their influence on lung disease onset and severity
Year: 2020


The lower airways microbiome in patients with IPF and COPD
Source: International Congress 2019 – Innovations in idiopathic pulmonary fibrosis
Year: 2019

Abnormal M1/M2 macrophage switching in small airway wall and lumen of smokers and COPD patients
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017

Expression of cholinergic system components in the airway epithelium of COPD patients
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008


Epithelial mesenchymal transition (EMT) related changes in small airways of smokers and patients with COPD
Source: Virtual Congress 2021 – Pathogenic progress in airway diseases
Year: 2021


Increased expression of SARS-CoV-2 (Covid-19) adhesion sites on type II pneumocytes, small airway epithelium, and alveolar macrophages in smokers and patients with COPD
Source: Virtual Congress 2021 – Mechanistic pathways in chronic and new lung diseases
Year: 2021



Decreased expression of TGFβ1 type II receptor in bronchial glands of smokers with COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 98s
Year: 2004

Increased circulating alveolar epithelial microparticles in COPD patients
Source: International Congress 2015 – Modulating the immune system in COPD and asthma
Year: 2015