Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study

Jacob T. Mey, Adithya Hari, Christopher L. Axelrod, Ciarán E. Fealy, Melissa L. Erickson, John P. Kirwan, Raed A. Dweik, Gustavo A. Heresi

Source: Eur Respir J, 55 (4) 1901700; 10.1183/13993003.01700-2019
Journal Issue: April
Disease area: Pulmonary vascular diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Jacob T. Mey, Adithya Hari, Christopher L. Axelrod, Ciarán E. Fealy, Melissa L. Erickson, John P. Kirwan, Raed A. Dweik, Gustavo A. Heresi. Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study. Eur Respir J, 55 (4) 1901700; 10.1183/13993003.01700-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Metabolic syndrome, fasting glucose and arterial stiffness in patients with COPD: The CIROCO study
Source: Annual Congress 2010 - Pulmonary rehabilitation and chronic care: new developments in interventions, assessment and care
Year: 2010

Insulin resistance in pulmonary arterial hypertension
Source: Eur Respir J 2009; 33: 318-324
Year: 2009



Fat metabolism in chronic respiratory disease
Source: ISSN=1025-448x, ISBN=1-904097-27-8, page=34
Year: 2003

Hypoxia effect on the hepatic profile, glucose metabolism and cardiovascular risk.
Source: International Congress 2018 – Cardiovascular and metabolic consequences of sleep-disordered breathing
Year: 2018


Peripheral insulin resistance accounts for impaired glucose tolerance and is associated with systemic inflammation in COPD
Source: Annual Congress 2011 - New mechanisms in airway disease
Year: 2011

Whole-body resting and exercise-induced lipolysis in sarcopaenic patients with COPD
Source: Eur Respir J 2008; 32: 1466-1471
Year: 2008



Plasma nitrite/nitrate levels: a new biomarker for pulmonary arterial hypertension?
Source: Eur Respir J 2016; 48: 1265-1267
Year: 2016


Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension
Source: Eur Respir J, 53 (6) 1801524; 10.1183/13993003.01524-2018
Year: 2019



Autoimmunity and pulmonary arterial hypertension: The role of leptin
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011

In-vivo lung molecular imaging of choline metabolism in a rat model of pulmonary arterial hypertension
Source: International Congress 2019 – Pulmonary hypertension with lung diseases and experimental pulmonary hypertension
Year: 2019


Prognostic value of blood gas analyses in patients with idiopathic pulmonary arterial hypertension
Source: Eur Respir J 2007; 29: 944-950
Year: 2007



Impaired glucose tolerance in COPD patients with hypoxaemia
Source: Eur Respir J 2001; 18: Suppl. 33, 211s
Year: 2001

Impact of therapies on insulin resistance in pulmonary arterial hypertension
Source: Annual Congress 2010 - Pulmonary circulation: clinical aspects
Year: 2010


Acetylene single breath estimation of effective pulmonary blood flow in patients with pulmonary arterial hypertension (PAH)
Source: Eur Respir J 2006; 28: Suppl. 50, 423s
Year: 2006

Serum and pulmonary uric acid in pulmonary arterial hypertension
Source: Eur Respir J, 58 (2) 2000332; 10.1183/13993003.00332-2020
Year: 2021



Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms
Source: Eur Respir Rev, 30 (160) 200284; 10.1183/16000617.0284-2020
Year: 2021



Changes in red blood cell membrane structure in pulmonary arterial hypertension
Source: International Congress 2016 – Clinic of pulmonary hypertension
Year: 2016

Is the increase in NO lung transfer due to free plasmatic hemoglobin in pulmonary arterial hypertension?
Source: International Congress 2015 – Pulmonary hypertension in lung disease
Year: 2015


Diabetes and metabolic aspects of OSA
Source: Eur Respir Mon 2010; 50: 189-215
Year: 2010


Is systemic oxygen extraction on exercise impaired in pulmonary arterial hypertension?
Source: Annual Congress 2013 –Pulmonary circulation: clinical physiology
Year: 2013