Signaling in vascular endothelium by varying degrees of mechanical stretch

P. Karki (Baltimore, United States of America), C. Zhao (Baltimore, United States of America), Y. Ke (Baltimore, United States of America), K. Birukov (Baltimore, United States of America), A. Birukova (Baltimore, United States of America)

Source: Respiratory Failure and Mechanical Ventilation Conference 2020
Session: Invasive mechanical ventilation
Session type: Poster Discussion
Number: 65
Disease area: Respiratory critical care

Congress or journal article abstractPDF journal article, handout or slidesE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. Karki (Baltimore, United States of America), C. Zhao (Baltimore, United States of America), Y. Ke (Baltimore, United States of America), K. Birukov (Baltimore, United States of America), A. Birukova (Baltimore, United States of America). Signaling in vascular endothelium by varying degrees of mechanical stretch. Respiratory Failure and Mechanical Ventilation Conference 2020

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Mechanical cyclic stretch of the respiration and in vitro microvascular remodeling
Source: International Congress 2018 – Genetics in chronic pulmonary diseases
Year: 2018


Integrity of cytoskeleton is essential for human pulmonary microvascular endothelial cell resistance against mechanical stress
Source: Eur Respir J 2005; 26: Suppl. 49, 97s
Year: 2005

Induction of endothelial gene expression by mechanical stretch
Source: Annual Congress 2004 - Role of mechanical stretch in respiratory pathophysiology
Year: 2004

Late Breaking Abstract - The effects of BMPRII loss on endothelial shear adaptation in the pulmonary vascular endothelium
Source: International Congress 2019 – Haemodynamics and chronic thromboembolic pulmonary hypertension
Year: 2019

Novel determinants of mechanical strain-induced endothelial cell apoptosis
Source: Annual Congress 2010 - Experimental pulmonary hypertension
Year: 2010

Endothelial dysfunction in a cell culture model exposed to various modes with different intermittent hypoxia frequencies and degrees
Source: International Congress 2019 – Novel methods, diagnostics and biomarkers in chronic lung diseases
Year: 2019

Substrate stiffness and geometry differentially regulate proliferation in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Role of endothelial and smooth muscle cells in vascular wall remodeling of large pulmonary arteries in patients with CTEPH
Source: Annual Congress 2007 - Venous thromboembolic disease
Year: 2007


SMAD3 regulation contributes to lung vascular remodeling in pulmonary arterial hypertension
Source: International Congress 2015 – Respiratory translational research: novel mechanisms, diagnostic markers and Space Odyssey
Year: 2015



The mechanics of smooth muscle cells in asthma: to stretch or not to stretch
Source: Annual Congress 2004 - Role of mechanical stretch in respiratory pathophysiology
Year: 2004

The effect of ASK1 inhibition on hypoxia-induced pulmonary artery fibroblast activation and associated paracrine effects on vascular smooth muscle cells
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016

Stretch-induced changes in constricted lung parenchymal strips: role of extracellular matrix
Source: Eur Respir J 2004; 23: 193-198
Year: 2004



FGF-2 modulates human airway smooth muscle contractile protein expression and cell stiffness
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Implication of aquaporin-1 in the stress response of human pulmonary microvascular endothelial cells
Source: International Congress 2019 – Biomarkers, laboratory findings and pre-clinical data in acute respiratory failure
Year: 2019


Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells - role of hypoxia-inducible transcription factors
Source: Eur Respir J 2001; 18: Suppl. 33, 159s
Year: 2001

Iloprost protects against lung endothelial barrier dysfunction and vascular leak via Rap1
Source: Annual Congress 2009 - Crossing the line: alveolo-capillary barrier control in acute lung injury
Year: 2009



Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery
Source: Eur Respir J 2009; 34: 1338-1347
Year: 2009



Focal adhesions control stretch-induced rho signaling and vascular permeability via paxillin – GEF-H1 functional complex
Source: International Congress 2014 – Experimental models in acute lung injury
Year: 2014

The transforming growth factor-β/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension
Source: Eur Respir J 2007; 29: 1094-1104
Year: 2007