Nintedanib has acute pulmonary vasodilatory effects in transgenic Fra2 mice with spontaneous progressive pulmonary hypertension and lung fibrosis.

N. Chandran (Graz, Austria), N. Sharma (Graz, Austria), L. Wollin (Biberach, Germany), A. Olschewski (Graz, Austria), G. Kwapiszewska (Graz, Austria), H. Olschewski (Graz, Austria)

Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Session: Translational aspects of idiopathic pulmonary fibrosis
Session type: Poster Discussion
Number: 5382
Disease area: Interstitial lung diseases, Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Chandran (Graz, Austria), N. Sharma (Graz, Austria), L. Wollin (Biberach, Germany), A. Olschewski (Graz, Austria), G. Kwapiszewska (Graz, Austria), H. Olschewski (Graz, Austria). Nintedanib has acute pulmonary vasodilatory effects in transgenic Fra2 mice with spontaneous progressive pulmonary hypertension and lung fibrosis.. 5382

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Caspase inhibition reduces severe pulmonary hypertension in the AdTGF-1β/SU5416 model of angioproliferative pulmonary hypertension and lung fibrosis
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011

Macitentan reduces progression of TGF-ß1-induced pulmonary fibrosis and pulmonary hypertension
Source: Eur Respir J, 52 (2) 1701857; 10.1183/13993003.01857-2017
Year: 2018



The effect of pulmonary macrophage transplantation in the pulmonary fibrosis of mice
Source: Virtual Congress 2021 – Developments in biomarkers and treatment strategies for chronic lung diseases
Year: 2021


Role of NFATc3 in chronic hypoxia induced pulmonary hypertension in neonatal mice
Source: Annual Congress 2010 - Pulmonary vascular diseases
Year: 2010

The effect of lung diseases on pulmonary hypertension and the effect of pulmonary hypertension on the lung
Source: Virtual Congress 2021 – Pulmonary hypertension in the COVID-19 pandemic and beyond
Year: 2021


Effect of fasudil on the bleomycin-induced pulmonary fibrosis and hypertension in mice
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms
Year: 2012



17(R)-resolvinD1 improves MMP-9/TIMP-1 imbalance leading to amelioration of pulmonary fibrosis in mice
Source: International Congress 2016 – ILD pathogenesis
Year: 2016


Acute exacerbations and pulmonary hypertension in advanced idiopathic pulmonary fibrosis
Source: Eur Respir J 2012; 40: 93-100
Year: 2012



A potential role for sildenafil in the management of pulmonary hypertension associated with parenchymal lung disease
Source: Eur Respir J 2006; 28: Suppl. 50, 425s
Year: 2006

The effect of acetazolamide on pulmonary hypertension induced by chronic hypoxia in rats
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008


Inflammatory cell accumulation in pulmonary arteries is associated with systemic inflammation in patients with chronic thromboembolic pulmonary hypertension (CTEPH)
Source: Annual Congress 2010 - Pulmonary venous thromboembolic disease
Year: 2010


Treatment of pulmonary hypertension in chronic obstructive pulmonary disease
Source: ISSN=ISSN 1025-448x, ISBN=ISBN 1-904097-48-0, page=313
Year: 2006

17(R)-resolvin D1 attenuates bleomycin-induced lung fibrosis in mice
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


Therapeutic hypercapnia prevents pulmonary hypertension in rats with bleomycin-induced chronic neonatal lung injury
Source: Annual Congress 2011 - Resuscitation and ventilation in the baby and infant
Year: 2011


Effects of hypoxia-induced chronic changes in pulmonary haemodynamics on the lung function and responsiveness in rats
Source: Annual Congress 2009 - Experimental approaches in animals and modelling in humans
Year: 2009


Suppressed pulmonary expression of leptin in lipopolysaccharide-induced acute and chronic lung inflammation
Source: Annual Congress 2006 - Novel pathogenic aspects of acute lung injury and acute respiratory distress syndrome (ARDS)
Year: 2006


VEGF gene transfer enhances fibrosis but improves pulmonary hemodynamics in experimental pulmonary fibrosis
Source: Annual Congress 2008 - Animal models of pulmonary fibrosis: mechanisms and therapies
Year: 2008

Pulmonary hypertension in patients with idiopathic pulmonary fibrosis and combined pulmonary fibrosis and emphysema: hemodynamic severity
Source: International Congress 2018 – Pulmonary hypertension in lung diseases and the role of the right ventricle
Year: 2018

Severe pulmonary hypertension in lung disease: phenotypes and response to treatment
Source: Eur Respir J 2015; 46: 1378-1389
Year: 2015



Improvement of exercise capacity in monocrotaline induced pulmonary hypertension by the phosphodiesterase inhibitor Vardenafil
Source: Annual Congress 2006 - Signalisation in the pulmonary vasculature: new pathways and wrong signals
Year: 2006