Il-4 and IL-13 act independently and synergistically to drive type 2 inflammation

A. Le Floc'H (Tarrytown, United States of America), J. Allinne (Tarrytown, United States of America), K. Nagashima (Tarrytown, United States of America), G. Scott (Tarrytown, United States of America), D. Birchard (Tarrytown, United States of America), S. Asrat (Tarrytown, United States of America), M. Sleeman (Tarrytown, United States of America), A. Murphy (Tarrytown, United States of America), J. Orengo (Tarrytown, United States of America)

Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Session: Novel mechanisms elucidated by translational studies of asthma
Session type: Poster Discussion
Number: 5206
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Le Floc'H (Tarrytown, United States of America), J. Allinne (Tarrytown, United States of America), K. Nagashima (Tarrytown, United States of America), G. Scott (Tarrytown, United States of America), D. Birchard (Tarrytown, United States of America), S. Asrat (Tarrytown, United States of America), M. Sleeman (Tarrytown, United States of America), A. Murphy (Tarrytown, United States of America), J. Orengo (Tarrytown, United States of America). Il-4 and IL-13 act independently and synergistically to drive type 2 inflammation. 5206

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Increased TGF-β-inducible early gene (TIEG) in human eosinophils stimulated by Th-2 type inflammatory cytokines
Source: Eur Respir J 2005; 26: Suppl. 49, 659s
Year: 2005

Interleukin-17 enhances epithelial IL-6 production solely by stabilizing IL-6 mRNA, which is reversed by microRNA16
Source: Eur Respir J 2007; 30: Suppl. 51, 212s
Year: 2007

IL-33 augments rhinovirus-induced type 2 immune responses in asthma via selective upregulation of one chain of the IL-33 receptor.
Source: International Congress 2017 – "Alarming" immunological patterns in asthma
Year: 2017


IL-15 transpresentation in circulating progenitors of NK cells controls their differentiation potential, STAT6 activation and IL-13 production
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


IL-10 produced by CD4+ T cells is essential for the development of airway hyperresponsiveness via suppression of endogenous IL-12
Source: Eur Respir J 2005; 26: Suppl. 49, 24s
Year: 2005

Aerobic training modulates parenquimal inflammation via decreases of IL-4 and IL-5 release by inflammatory cells
Source: Annual Congress 2007 - Towards an understanding of asthma pathogenesis - novel in vitro assays and results from animal models
Year: 2007


Fevipiprant is superior to montelukast in suppressing type 2 cytokine production from mast cell stimulated human Th2 cells
Source: International Congress 2019 – Precision meets immunology in treatment of airway diseases
Year: 2019




Influence of montelukast on T cell migration, production of Th2-type cytokines and proinflammatory cytokines
Source: Eur Respir J 2004; 24: Suppl. 48, 129s
Year: 2004

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Pro- and anti-inflammatory cytokines TNF-alpha, IFN-gamma, IL-10 and TGF-beta1 levels in blood serum as markers of plasmaferesis success and inflammation activity in lung sarcoidosis (LS)
Source: Eur Respir J 2006; 28: Suppl. 50, 676s
Year: 2006

Interleukin-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction
Source: Eur Respir J 2005; 26: Suppl. 49, 2s
Year: 2005

IL-4 induces Th2 cells to resist the IL-27 counterregulation by downregulating STAT1 and STAT2 phosphorylation
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012

IL-18 and IL-12 induce inflammatory cytokines, chemokine ligand 9 (CXCL9) and T cell infiltration in pulmonary tissue
Source: Annual Congress 2011 - Lung cell injury and repair
Year: 2011


Chemokinome characterization in human lung macrophages following stimulation with Th2-type cytokines IL-4 or IL-13
Source: Annual Congress 2012 - Update on neutrophil and macrophage function in COPD
Year: 2012

IL-18, a novel Th1 cytokine, is up-regulated in pulmonary tuberculosis: expression and production by alveolar epithelial cells type II
Source: Eur Respir J 2002; 20: Suppl. 38, 213s
Year: 2002

IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis
Source: Eur Respir J 2001; 17: 403-415
Year: 2001



Interleukin (IL-13) modulates allergen-induced airway hyperresponsiveness by a pathway independent of IL-5 or eotaxin in mice
Source: Eur Respir J 2003; 22: Suppl. 45, 194s
Year: 2003

mRNA expression for Th2 and Th1 derived cytokines in induced sputum
Source: Eur Respir J 2001; 18: Suppl. 33, 271s
Year: 2001

Exaggerated IL-6 responses to LPS after viral airway infection in mice is mediated by endogenous TNF-a production
Source: Annual Congress 2007 - Immunological function in viral and nonviral pathogens
Year: 2007