Genetic deletion of the Cl channel Slc26a9 causes airway mucus obstruction and mortality in neonatal mice

J. Salomon (Heidelberg, Germany), P. Millar Büchner (Heidelberg, Germany), S. Spahn (Heidelberg, Germany), W. Wagner (Heidelberg, Germany), J. Schatterny (Heidelberg, Germany), S. Butz (Heidelberg, Germany), M. Mall (Berlin, Germany)

Source: International Congress 2019 – Novel insights from in vitro and in vivo models of lung disease
Session: Novel insights from in vitro and in vivo models of lung disease
Session type: Thematic Poster
Number: 4076
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Salomon (Heidelberg, Germany), P. Millar Büchner (Heidelberg, Germany), S. Spahn (Heidelberg, Germany), W. Wagner (Heidelberg, Germany), J. Schatterny (Heidelberg, Germany), S. Butz (Heidelberg, Germany), M. Mall (Berlin, Germany). Genetic deletion of the Cl channel Slc26a9 causes airway mucus obstruction and mortality in neonatal mice. 4076

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
HDAC6 inhibition and deletion reduce COPD symptoms in mice and human airway epithelia
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




Augmented susceptibility to hyperoxia-induced pulmonary edema in mice with deficient amiloride-sensitive sodium transport-dependent alveolar fluid clearance
Source: Eur Respir J 2001; 18: Suppl. 33, 317s
Year: 2001

VAChT reduction increased mortality probably due to alveolar edema in a model of lung injury induced by intestinal isquemia/reperfusion in female mice.
Source: International Congress 2017 – Sepsis, infections, ARDS and beyond
Year: 2017

Allergic airway inflammation induces a pro-secretory epithelial ion transport phenotype in mice
Source: Eur Respir J 2010; 36: 1436-1447
Year: 2010



Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration
Source: Eur Respir J, 59 (2) 2100185; 10.1183/13993003.00185-2021
Year: 2022



Effect of n-butyldeoxynojirimycin on chloride efflux from CF airway epithelial cells
Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Year: 2009

Interactions between zinc deficiency and murine airway inflammation on apoptosis in airway epithelium
Source: Eur Respir J 2003; 22: Suppl. 45, 267s
Year: 2003

Alveolar epithelial fluid transport in acute lung injury: new insights
Source: ISSN=1025-448x, ISBN=1-904097-23-5, page=47
Year: 2002

Exercise reduces airway sodium ion reabsorption in cystic fibrosis but not in exercise asthma
Source: Eur Respir J 2011; 37: 342
Year: 2011



Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue
Source: Eur Respir J 2012; 40: 1390-1400
Year: 2012



Hypertonic saline alters ion transport across the human airway epithelium
Source: Eur Respir J 2001; 17: 195-199
Year: 2001



Loss of CFTR causes endothelial barrier failure in pneumonia via inhibition of WNK1 and TRPV4 activation
Source: International Congress 2017 – From respiratory muscles to acute respiratory failure
Year: 2017

The zinc transporter ZnT4 is depleted in the airway epithelium in a mouse model of asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 100s
Year: 2004

Transgenic mice expressing a surfactant protein-B-urokinase-fusion protein in the distal respiratory epithelium show an attenuated fibrotic response to bleomycin-induced lung injury
Source: Annual Congress 2005 - In vivo - approaches to lung injury
Year: 2005


Effects of acute hypovolaemia by furosemide on tracheal transepithelial potential difference and mucus in dogs
Source: Eur Respir J 2004; 24 : 805-810
Year: 2004



Plp1 mutation induces altered respiratory response to an airway challenge
Source: Annual Congress 2012 - New understanding of childhood lung disease through physiological measurement
Year: 2012


The profibrotic role of downregulated Na,K-ATPase ß1 subunit in alveolar epithelium cells in lung fibrosis
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018

Role of S-nitrosoglutathione and hypothermia in regulation of mutant δF508 CFTR expression in airway epithelial cells
Source: Annual Congress 2009 - Cystic fibrosis: understanding a complex disease
Year: 2009


Nasal transepithelial potential difference does not reflect beta2-adrenergic stimulation of transepithelial sodium transport-driven alveolar fluid clearance in mice
Source: Eur Respir J 2001; 18: Suppl. 33, 257s
Year: 2001

LSC 2011 Abstract: Combined nasal exposure to sodium hypochlorite and ovalbumin induces airway hyperreactivity in mice through activation of the TRPA1 channel and mast cells
Source: Annual Congress 2011 - Environmental exposure and disease mechanisms
Year: 2011