TLR7 Expression Reveals Novel Bronchodilating Mechanism of Imidazoquinoline Agonists

B. Proskocil (Portland, United States of America), A. Fryer (Portland, United States of America), D. Jacoby (Portland, United States of America), M. Drake (Portland, United States of America)

Source: International Congress 2019 – Advances in asthma pharmacology
Session: Advances in asthma pharmacology
Session type: Poster Discussion
Number: 3883
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
B. Proskocil (Portland, United States of America), A. Fryer (Portland, United States of America), D. Jacoby (Portland, United States of America), M. Drake (Portland, United States of America). TLR7 Expression Reveals Novel Bronchodilating Mechanism of Imidazoquinoline Agonists. 3883

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Aerosolized TLR7 Imidazoquinoline Agonist Bronchodilates In Vivo
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018



Late Breaking Abstract - ACE2 Overexpression Modulates Nicotine Receptors In Cell Type Specific Manner: Possible Relevance In Covid-19
Source: Virtual Congress 2021 – Late breaking basic and translational science of SARS-Cov2 and COVID-19
Year: 2021



RAGE Partially Mediates Cigarettes Smoke Extract induced Cytokine and Chemokine Production in Human Bronchial Epithelial Cells
Source: International Congress 2018 – COPD: immune regulation and therapeutic targets
Year: 2018


The Effect of Cordycepin and Simvastatin on Cigarettes Smoke Extract Induced Cytokine and Chemokine Production in Human Bronchial Epithelial Cells
Source: International Congress 2018 – COPD: immune regulation and therapeutic targets
Year: 2018


The Discovery and Development of AZD1402/PRS-060, an Inhaled, Potent and Selective Antagonist of the IL-4 Receptor Alpha
Source: International Congress 2018 – Basic pharmacology
Year: 2018

Endogenous Anti-Inflammatory Mechanisms and the Role of Lipoxins
Source: Research Seminar 2007 - Severe Asthma
Year: 2007

PP212 – The Anti-Fibrotic Drug Nintedanib Promotes Repair Macrophages
Source: ERS Lung Science Conference 2021
Year: 2021

Erythromycin Reverses Nets-induced Corticosteroid Insensitivity By Inhibition Of The Pi3kd/akt Pathway
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Comprehensive Metabolic Profiling Reveals Metabolic Perturbances and Identifies Potential Biomarkers in Chronic Persistent Bronchial Asthma with Different Levels of Eosinophilia Percentage
Source: International Congress 2019 – Evaluation of basic science in airway diseases
Year: 2019


Exosomes from Intermittent Hypoxia Treated Lung Adenocarcinoma Cell Line Up-regulate Programmed Death Ligand 1 Expression through HIF-1a Pathway in Macrophages
Source: Virtual Congress 2020 – Biological aspects of lung cancer
Year: 2020


Distal Lung Epithelial Regeneration is Driven by Notch Pathway Inhibition and Enhanced by Ex Vivo Native Lung Scaffold Biomimetic Culture
Source: International Congress 2019 – Injury and repair: less is more
Year: 2019



Late Breaking Abstract - Chronic Hypoxia Promotes Pulmonary Venous Smooth Muscle Cells Proliferation by Upregulating Calcium Sensing Receptor
Source: International Congress 2018 – Molecular mechanisms and treatment of pulmonary hypertension
Year: 2018

Effects of Inhaled Long Acting Muscarinic Antagonist (LAMA) on Lung Functions in Adult Stable Bronchiectasis
Source: International Congress 2018 – COPD management
Year: 2018


Mast Cell Tryptase Enhances Wound-Healing via Protease-Activated Receptor-2 Dependent Migration in Human Bronchial Epithelial Cells
Source: Virtual Congress 2021 – Cellular and molecular involvement in lung injury and repair
Year: 2021



Understanding of Pharmacokinetics and Exposure Drives use of Nintedanib as a Positive Control Reference Item in a Rat Model of Bleomycin-Induced Fibrosis
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019

Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea
Source: International Congress 2018 – Pathophysiological aspects of sleep-disordered breathing: intermittent hypoxia
Year: 2018



Transcriptional Signature Identifies Phenotypic Heterogeneity of Human Tuberculosis Infection
Source: International Congress 2018 – The immune response to tuberculosis: development of biomarkers and diagnostic tools
Year: 2018

Inhibition of LncRNA MALAT1 Protects H9c2 Cells against Intermittent Hypoxia-Induced Injury by Targeting MiRNA-193a-3p
Source: Virtual Congress 2020 – Pathophysiology and treatment of obstructive sleep apnoea
Year: 2020

Characterization of the Immune Response in Clinical Sepsis To Identify Potential Therapeutic Targets
Source: Virtual Congress 2020 – Biomarkers and characterisation of immune response in respiratory infection
Year: 2020


Late Breaking Abstract - Endothelial Cell-Specific Anticoagulation Reduces Inflammation in a Mouse Model of ALI
Source: International Congress 2017 – Anti-inflammatory and pro-repair mediators in acute lung injury
Year: 2017