Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids

Prasad Nagakumar, Franz Puttur, Lisa G. Gregory, Laura Denney, Louise Fleming, Andrew Bush, Clare M. Lloyd, Sejal Saglani

Source: Eur Respir J, 54 (2) 1801809; 10.1183/13993003.01809-2018
Journal Issue: August
Disease area: Airway diseases, Paediatric lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Prasad Nagakumar, Franz Puttur, Lisa G. Gregory, Laura Denney, Louise Fleming, Andrew Bush, Clare M. Lloyd, Sejal Saglani. Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids. Eur Respir J, 54 (2) 1801809; 10.1183/13993003.01809-2018

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Type two innate lymphoid cells (ILC2s) in the blood of children with acute asthma
Source: International Congress 2017 – Diagnostic tools in paediatric asthma
Year: 2017


Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin
Source: International Congress 2018 – Roles of innate lymphoid cells in asthma
Year: 2018


Role of innate lymphoid cells and the epithelium in asthma and bronchoconstriction
Source: International Congress 2018 – It's my favourite cell that affects your asthma
Year: 2018


Pulmonary dendritic cells from chronic obstructive pulmonary disease patients suppress lung immune responses through induction of regulatory T cells
Source: Annual Congress 2011 - T-cell subsets
Year: 2011

Rhinovirus induced innate immune responses in the epithelium of severe COPD
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019


Lymphoid follicles in (very) severe COPD: beneficial or harmful?
Source: Eur Respir J 2009; 34: 219-230
Year: 2009



Assessment of innate immunity mediators in the lung of COPD patients: relation with disease manifestations
Source: Virtual Congress 2020 – Host-microbe interactions and their influence on lung disease onset and severity
Year: 2020


Pulmonary and systemic cellular immune response network in patients with mild-moderate COPD
Source: International Congress 2017 – Systemic and airway biomarkers
Year: 2017

Severe asthma: from inflammatory phenotype to treatment
Source: International Congress 2017 – Chinese Programme 2017
Year: 2017


Anticholinergic treatment does not affect toll-like receptor 3-induced antiviral immune response in COPD bronchial epithelial cells
Source: International Congress 2015 – New data on established treatments for COPD
Year: 2015

Allergen-experienced group 2 innate lymphoid cells acquire memory-like properties and enhance allergic lung inflammation
Source: International Congress 2018 – Roles of innate lymphoid cells in asthma
Year: 2018


Dysregulation of type 2 innate lymphoid cells and Th2 cells impairs pollutant-induced allergic airway responses
Source: International Congress 2016 – Immune responses in the lung
Year: 2016

Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155
Source: Eur Respir J, 56 (3) 1901289; 10.1183/13993003.01289-2019
Year: 2020



The fraction of circulating type 2 innate lymphoid cells in peripheral blood is associated with asthma severity
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

How cultured epithelial cells from asthma and COPD patients deal with pathogens: defective anti-rhinovirus responses in asthma
Source: Research Seminar 2008 - Host-pathogen interactions in the lung: implications for treatment of respiratory infections and inflammatory lung diseases
Year: 2008

Severe asthma in old patients is characterized by signs of immunosuppression and by lymphocyte resistance to glucocorticoids
Source: Annual Congress 2012 - Aspects of clinical asthma
Year: 2012


Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1
Source: Eur Respir J, 57 (3) 2000018; 10.1183/13993003.00018-2020
Year: 2021



Evidence of a distinct phenotype of adult onset asthma characterized by an airway neutrophilia and poor response to inhaled corticosteroids
Source: Eur Respir J 2001; 18: Suppl. 33, 21s
Year: 2001