Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD

Katherine J. Baines, Thomas K. Wright, Peter G. Gibson, Heather Powell, Philip M. Hansbro, Jodie L. Simpson

Source: ERJ Open Res, 4 (4) 00031-2018; 10.1183/23120541.00031-2018
Journal Issue: October
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Katherine J. Baines, Thomas K. Wright, Peter G. Gibson, Heather Powell, Philip M. Hansbro, Jodie L. Simpson. Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD. ERJ Open Res, 4 (4) 00031-2018; 10.1183/23120541.00031-2018

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Relationship between blood eosinophil count and bronchial epithelial gene expression in COPD versus Asthma
Source: International Congress 2018 – Eosinophils in airway disease
Year: 2018



A sputum gene expression signature predicts oral corticosteroid response in asthma
Source: Eur Respir J, 49 (6) 1700180; 10.1183/13993003.00180-2017
Year: 2017



Variation in the TLR4 gene and airway inflammation among patients with COPD
Source: Annual Congress 2009 - Genetics in the smokers corner: from inflammation in smokers via COPD to cancer
Year: 2009


Treatment: how does inflammatory phenotype influence response to treatment in airway disease?
Source: Annual Congress 2007 - Inflammatory phenotypes in airway disease
Year: 2007


Association of sputum chitinase like protein levels with pathophysiology and neutrophilic airway inflammation in asthma
Source: Annual Congress 2008 - Invasive and noninvasive measurements of lung inflammation
Year: 2008


The expression of CD39 mRNA is altered in peripheral blood of patients with allergic asthma
Source: Annual Congress 2013 –Genetics and mechanisms of, and tests for, allergy
Year: 2013

Airway inflammation in COPD: physiological outcome measures and induced sputum
Source: Eur Respir J 2003; 21: 19S-28S
Year: 2003



Effects of salmeterol/fluticasone propionate (SFC) on airway inflammation in induced sputum in COPD
Source: Annual Congress 2005 - Effects of anti-inflammatory drugs on COPD
Year: 2005


Analysis of cytokine gene expression after treatment and pulmonary rehabilitation of acute exacerbation in COPD
Source: International Congress 2019 – Exacerbations of airway diseases
Year: 2019

Chronic sputum production in COPD is a marker for airway inflammation and colonisation
Source: Eur Respir J 2004; 24: Suppl. 48, 306s
Year: 2004

Photobiomodulation and corticosteroid modulate pulmonary inflammation and airway reactivity in an experimental model of chronic asthma
Source: International Congress 2018 – Basic pharmacology
Year: 2018

Increased numbers of alveolar mast cells with an altered phenotype are linked to peripheral airway remodelling in patients with allergic asthma
Source: Annual Congress 2012 - Mechanisms of asthma
Year: 2012

Effect of COPD exacerbations on early lung function decline under maintenance therapy: blood eosinophil count asbiomarker
Source: International Congress 2019 – Eosinophils and FeNO in airway diseases
Year: 2019




Association between bacterial load and inflammatory gene expression in COPD exacerbations
Source: International Congress 2018 – How far are we in terms of predicting mortality and exacerbations in COPD?
Year: 2018




The lung microbiota changes associated with inhaled corticosteroid and azithromycin in murine model of COPD
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

The use of sputum differential cell counts and soluble phase measurements to assess airway inflammation in children with asthma exacerbation
Source: Eur Respir J 2002; 20: Suppl. 38, 142s
Year: 2002

COPD is associated with reduced pulmonary interstitial expression of pentraxin-3
Source: Eur Respir J 2012; 39: 830-838
Year: 2012



Meta-analysis of airway epithelium gene expression in asthma
Source: Eur Respir J, 51 (5) 1701962; 10.1183/13993003.01962-2017
Year: 2018



Same role and same treatment for airway eosinophilia in asthma and COPD?
Source: Eur Respir J 2007; 29: 831-833
Year: 2007


Chronic sputum production and airway inflammation in COPD in the stable state and at exacerbation
Source: Eur Respir J 2005; 26: Suppl. 49, 442s
Year: 2005