IL-37 ameliorates experimental asthma by inhibiting IL-1

A. Schroeder (Borstel, Germany), L. Lunding (Borstel, Germany), C. Vock (Borstel, Germany), B. Schaub (Munich, Germany), U. Zissler (Munich, Germany), H. Fehrenbach (Borstel, Germany), M. Wegmann (Borstel, Germany)

Source: International Congress 2018 – Novel immunology-based therapies in asthma and COPD
Session: Novel immunology-based therapies in asthma and COPD
Session type: Oral Presentation
Number: 1647
Disease area: Airway diseases

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Schroeder (Borstel, Germany), L. Lunding (Borstel, Germany), C. Vock (Borstel, Germany), B. Schaub (Munich, Germany), U. Zissler (Munich, Germany), H. Fehrenbach (Borstel, Germany), M. Wegmann (Borstel, Germany). IL-37 ameliorates experimental asthma by inhibiting IL-1. 1647

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Exacerbation of experimental asthma depends on IL-6 but not on IL-23 or ROR?t
Source: International Congress 2017 – Animal models of asthma and allergies
Year: 2017

LSC - 2017 - IL-1R1 but not IL-18Rbeta or IL-18BP contribute to the beneficial effects of IL-37 on experimental asthma
Source: International Congress 2017 – Asthma and allergy: from the bench to the bedside
Year: 2017

Importin-7 knockdown reduces corticosteroid induced glucocorticoid receptor nuclear localisation and suppression of IL-1beta induced CXCL8
Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management
Year: 2013

Inhibition of LPS-induced cytokine/chemokine production from human lung macrophages by roflumilast is enabled by autocrine PGE2
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010


Estrogen protects against airway inflammation via upregulation of SLPI and downregulation of IL-33
Source: Annual Congress 2012 - Asthma: mechanisms of airway inflammation
Year: 2012

Role of proinflammatory cytokines IL-18 and IL-1β in bleomycin-induced lung injury in humans and mice
Source: Annual Congress 2009 - Mechanisms of pulmonary inflammation and fibrosis
Year: 2009

IL-33 augments rhinovirus-induced type 2 immune responses in asthma via selective upregulation of one chain of the IL-33 receptor.
Source: International Congress 2017 – "Alarming" immunological patterns in asthma
Year: 2017


Caspase-1 induces upstream Th2-cytokines IL-33 and TSLP and eosinophilia at viral induced asthma exacerbations
Source: International Congress 2016 – Asthma: mechanisms and biomarkers that promote clinical understanding
Year: 2016

The GLP-1 receptor agonist Liraglutide attenuates intermittent hypoxia-induced pro-inflammatory macrophage polarization in primary macrophages
Source: Virtual Congress 2021 – From pathophysiology to different diagnostic modalities in sleep disordered breathing
Year: 2021



Statins suppress LPS-induced proinflammatory cytokine production from human bronchial epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Roflumilast inhibits chemokine release in animal models of COPD and asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 690s
Year: 2004

Overexpression of CBP augments cigarette smoke-induced pro-inflammatory cytokine release in macrophages
Source: Eur Respir J 2005; 26: Suppl. 49, 105s
Year: 2005

Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1? synthesis by human neutrophils
Source: Eur Respir J 2011; 37: 406
Year: 2011



The treatment of bleomycin-induced lung injury with combination of antioxidants and interleukin-1 receptor antagonist (IL-1ra)
Source: Eur Respir J 2002; 20: Suppl. 38, 488s
Year: 2002

Blocking IL-4Ra with dupilumab prevents lung inflammation in a mouse asthma model
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018


Carbocisteine in vivo reduces circulating miR-21 and IL-8 in exacerbated COPD patients
Source: International Congress 2019 – COPD clinical trials: inhaled and oral therapies
Year: 2019

IL-10 and IL-1ra mediates OVA-induced Th2 airway allergic response at short and long-term
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013


Interleukin-17 enhances epithelial IL-6 production solely by stabilizing IL-6 mRNA, which is reversed by microRNA16
Source: Eur Respir J 2007; 30: Suppl. 51, 212s
Year: 2007

Rhinovirus-induced cytokine production of circulating leukocytes is reduced in severe asthma
Source: Virtual Congress 2020 – New insight into the immunology of asthma and COPD
Year: 2020


TLR-4 downregulation in COPD impairs cytokine release from monocytes and Th1-lymphocytes in response to bacterial endotoxin
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009