Loss of IL-6 enables lung growth in newborn mice exposed to prolonged hyperoxia

D. Hirani (Köln, Germany), K. Dinger (Köln, Germany), J. Mohr (Köln, Germany), C. Vohlen (Köln, Germany), B. Darvishan (Köln, Germany), F. Klein (Köln, Germany), E. Lopez Garcia (Köln, Germany), M. Odenthal (Köln, Germany), J. Dötsch (Köln, Germany), M. Alejandre Alcazar (Köln, Germany)

Source: International Congress 2018 – Molecular and cellular determinants of the developing lung
Session: Molecular and cellular determinants of the developing lung
Session type: Thematic Poster
Number: 1381
Disease area: Paediatric lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Hirani (Köln, Germany), K. Dinger (Köln, Germany), J. Mohr (Köln, Germany), C. Vohlen (Köln, Germany), B. Darvishan (Köln, Germany), F. Klein (Köln, Germany), E. Lopez Garcia (Köln, Germany), M. Odenthal (Köln, Germany), J. Dötsch (Köln, Germany), M. Alejandre Alcazar (Köln, Germany). Loss of IL-6 enables lung growth in newborn mice exposed to prolonged hyperoxia. 1381

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Loss of IL-6 promotes alveolar progenitor cells and lung growth in newborn mice exposed to mechanical ventilation
Source: Virtual Congress 2020 – Airway development in health and disease
Year: 2020




Intermittent hypoxia induces lung growth in adult mice
Source: Annual Congress 2010 - Lung morbidity on exposure to various agents
Year: 2010

Impact of systemic erythropoietin deficiency on the lung of mice exposed to hypoxia
Source: International Congress 2018 – Triggers of acute lung injury: mechanical ventilation and oxygen levels
Year: 2018

G-CSF administration improves chronic lung disease caused by exposure to high-concentration oxygen in neonatal mice
Source: Annual Congress 2012 - Issues in neonatal and paediatric intensive care
Year: 2012

Role of TREM1-Ripk3 axis in hyperoxia induced lung injury in neonates.
Source: International Congress 2018 – Molecular and cellular determinants of the developing lung
Year: 2018

Myeloperoxidase -/- mice show decreased lung neutrophilia and increased epithelial cell proliferation after lipopolysaccharide or asbestos exposure
Source: Eur Respir J 2006; 28: Suppl. 50, 398s
Year: 2006

Effects of HSP70 induction on IL-6 production from murine alveolar epithelial cells pre-treated with endotoxine after subsequent endotoxin challenge
Source: Eur Respir J 2005; 26: Suppl. 49, 346s
Year: 2005

Exogenous administration of interleukin-6 affects the control of breathing in respiratory loaded mice
Source: Annual Congress 2010 - Sleep apnoea: insights from animal models and diagnostic tools
Year: 2010


Dexamethasone reduces lung inflammation induced by alveolar stretch in mice
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

The effect of GM-CSF on lung maturation and parenchymal NOS expression in prenatally treated Balb/c mice
Source: Eur Respir J 2005; 26: Suppl. 49, 341s
Year: 2005

Effect of induced hypothermia on alveolar macrophage function in endotoxin-challenged rats
Source: Eur Respir J 2002; 20: Suppl. 38, 485s
Year: 2002

Bronchiolar wall structure is altered in adult mice following neonatal hyperoxia
Source: Annual Congress 2012 - New understanding of childhood lung disease through physiological measurement
Year: 2012


Hyperoxia exposure induces age-dependent changes in gene expression in healthy mouse lung
Source: International Congress 2019 – Intercellular communication in tissue remodelling of chronic lung diseases
Year: 2019




Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia
Source: Eur Respir J 2009; 33: 861-870
Year: 2009



Increased toll-like receptor 4 expression in mice lung tissue under intermittent hypoxia
Source: Annual Congress 2012 - Physiology, heart failure and respiration in relation to OSA
Year: 2012

Enhanced expression of Robo4 ameliorates LPS-induced acute lung injury in mice
Source: Annual Congress 2011 - Acute respiratory failure
Year: 2011

Alteration of eicosanoid metabolism/signalling in IL-9 overexpressing mice and impact on lung fibrosis
Source: Eur Respir J 2007; 30: Suppl. 51, 575s
Year: 2007

Attenuation of lung inflammation and emphysema induced by cigarette smoke exposure in CXCR3 knockout mice
Source: Annual Congress 2008 - Cell biology of asthma and COPD
Year: 2008


Upregulated of NO-synthesising lung activity and its correction in LPS-induced lung injury in mice
Source: Eur Respir J 2004; 24: Suppl. 48, 551s
Year: 2004

Role of endogenous interleukin-17 in early neutrophil recruitment after endotoxin exposure in mouse airways in vivo
Source: Eur Respir J 2003; 22: Suppl. 45, 566s
Year: 2003