AMPK is inhibited in severe bronchiectasis and may relate to reduced ciliary beat frequency

Y. Giam (Dundee, United Kingdom), A. Shoemark (Dundee, United Kingdom), H. Keir (Dundee, United Kingdom), M. Contarini (Milan, Italy), D. Cassidy (Dundee, United Kingdom), S. Finch (Dundee, United Kingdom), J. Chalmers (Dundee, United Kingdom)

Source: International Congress 2018 – The global impact of bronchiectasis and nontuberculous mycobacteria (NTM)
Session: The global impact of bronchiectasis and nontuberculous mycobacteria (NTM)
Session type: Poster Discussion
Number: 351
Disease area: Respiratory infections

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Giam (Dundee, United Kingdom), A. Shoemark (Dundee, United Kingdom), H. Keir (Dundee, United Kingdom), M. Contarini (Milan, Italy), D. Cassidy (Dundee, United Kingdom), S. Finch (Dundee, United Kingdom), J. Chalmers (Dundee, United Kingdom). AMPK is inhibited in severe bronchiectasis and may relate to reduced ciliary beat frequency. 351

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Disrupted ciliated epithelium shows slower ciliary beat frequency and increased dyskinesia
Source: Eur Respir J 2009; 33: 401-404
Year: 2009



CAM-kinase II inhibition and protein kinase C activation combine synergistically to initiate ciliary beat frequency despite cellular hypothermia
Source: Eur Respir J 2002; 20: Suppl. 38, 88s
Year: 2002

Correlation of nasal nitric oxide, ciliary beat frequency, ciliary beat pattern and ultrastructural defects in patients referred to a national diagnostic centre for primary ciliary dyskinesia
Source: Annual Congress 2008 - Respiratory structure and function
Year: 2008

Effect of roflumilast, a PDE4 inhibitor, on ciliary beat frequency in human nasal epithelial cells
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

Relationship between the ciliary beat frequency (CBF) and the effect of zafirlukast in asthmatic patients
Source: Eur Respir J 2001; 18: Suppl. 33, 245s
Year: 2001

Persistent disruption of ciliated epithelium following paediatric lung transplantation
Source: Eur Respir J 2012; 40: 1245-1252
Year: 2012



Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary function
Source: Eur Respir J 2014; 44: 1253-1261
Year: 2014



Neutrophil elastase increases ciliary beat frequency ex-vivo: implications for the bronchiectasis airway
Source: International Congress 2018 – The global impact of bronchiectasis and nontuberculous mycobacteria (NTM)
Year: 2018


Corticosteroid insensitivity and enhanced mitogen-activated protein kinase activity in airway smooth muscle cells of severe asthma
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia (PCD)
Source: Annual Congress 2004 - Chronic respiratory illness in childhood
Year: 2004


TGFβ1 induced loss of β-adrenergic response in human bronchial smooth muscle cells (hBSMC) is dependent on TGFβ-RI kinase activity: potential therapeutic application in treating airway diseases
Source: Annual Congress 2003 - Mechanisms of lung injury: from bench to bedside
Year: 2003


Sympathetic activation in COPD patients is attenuated by slow breathing
Source: Eur Respir J 2006; 28: Suppl. 50, 174s
Year: 2006

Lignocaine with phenylephrine, but not lignocaine alone, causes a reduction in the ciliary beat frequency of nasal airway epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 78s
Year: 2003

HDAC6 inhibition and deletion reduce COPD symptoms in mice and human airway epithelia
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




Intracellular zinc and salbutamol modify ciliary beat frequency in human nasal airway epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 483s
Year: 2005

Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia
Source: Eur Respir J 2014; 44: 1579-1588
Year: 2014



Ciliary beat frequency in nasal and bronchial epithelial cells in patients with cystic fibrosis
Source: Annual Congress 2011 - Cystic fibrosis: new basic, clinical and bacteriological knowledge
Year: 2011


Hyperinflation associated with COPD is associated with impaired cardiac function and spontaneous baroreceptor sensitivity
Source: Annual Congress 2010 - COPD: cardiovascular comorbidities
Year: 2010


Inhibition of uPA-uPAR signaling restores respiratory epithelial barrier function in asthma and COPD
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019

Hypoxia induced cardiac dysfunction maybe caused by increased IL-18 levels leading to dephosphorylation of Ca2+ handling proteins
Source: Annual Congress 2007 - Novel mediators of cellular pathology
Year: 2007