Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis

Ringholz Fiona C., Buchanan Paul J., Clarke Donna T., Millar Roisin G., McDermott Michael, Linnane Barry, Harvey Brian J., McNally Paul, Urbach Valerie

Source: Eur Respir J 2014; 44: 394-404
Journal Issue: August
Disease area: Paediatric lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Ringholz Fiona C., Buchanan Paul J., Clarke Donna T., Millar Roisin G., McDermott Michael, Linnane Barry, Harvey Brian J., McNally Paul, Urbach Valerie. Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. Eur Respir J 2014; 44: 394-404

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Correlation between decrease of leukotriene B-4 and reactive protein C in cystic fibrosis patients
Source: Eur Respir J 2004; 24: Suppl. 48, 384s
Year: 2004

Chronic obstructive pulmonary disease is characterized with suppressed lipoxin A4 and increased lipoxin receptor expression in lungs
Source: Annual Congress 2012 - The smoking gun in COPD biology
Year: 2012

Lipoxin A4 and lipoxin A4 receptor expression in induced sputum of asthmatic children
Source: Eur Respir J 2007; 30: Suppl. 51, 267s
Year: 2007

Role of lipoxin A4 in induced sputum of asthmatic children
Source: Annual Congress 2008 - Invasive and noninvasive measurements of lung inflammation
Year: 2008

Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis
Source: Eur Respir J 2009; 34: 1444-1451
Year: 2009



Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients
Source: Eur Respir J 2004; 24: Suppl. 48, 20s
Year: 2004

Leukotriene B4 receptor blockade increases apoptosis of monocyte-derived macrophages from patients with COPD and emphysema
Source: Eur Respir J 2001; 18: Suppl. 33, 337s
Year: 2001

Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia
Source: Eur Respir J 2008; 32: 437-442
Year: 2008



Lipoxin A4 regulates bronchial epithelium responses to acid injury
Source: Eur Respir J 2006; 28: Suppl. 50, 660s
Year: 2006

Increased expression of the cysteinil leukotriene 1 receptor (CysLT1-R) in the bronchial epithelium of smokers
Source: Eur Respir J 2001; 18: Suppl. 33, 74s
Year: 2001

Increased leukotriene and lower prostaglandin E2 concentrations in induced sputum of patients with eosinophilic asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 733s
Year: 2005

Critical role of cytosolic phospholipase A2? in bronchial mucus hypersecretion in CFTR-deficient mice
Source: Eur Respir J 2010; 36: 1120-1130
Year: 2010



Increased exhaled cysteinyl-leukotrienes, leukotriene B4 and 8-isoprostane in exacerbation of COPD
Source: Eur Respir J 2001; 18: Suppl. 33, 248s
Year: 2001

Intranasal administration of leukotriene B4 selectively increases human nasal neutrophil activity
Source: Annual Congress 2008 - Phenotyping of asthma and COPD
Year: 2008



Anti-inflammatory effect of Lipoxin A4 (LXA4) on human bronchial epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 619s
Year: 2002

Upregulation of cysteinyl leukotriene receptors CysLT1 and CysLT2 by TGF-β1 and LTE4 on human bronchial epithelial cells
Source: Annual Congress 2006 - Airway epithelial cells in inflammation
Year: 2006


α1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients
Source: Eur Respir J 2007; 29: 240-250
Year: 2007



Involvement of eicosanoids and surfactant protein D in extrinsic allergic alveolitis
Source: Eur Respir J 2005; 26: 1069-1073
Year: 2005



Leukotriene C4 synthase deficiency causes spontaneous emphysematous changes in mice
Source: International Congress 2019 – Crosstalk in chronic pulmonary diseases
Year: 2019

Alternative transcripts of cysteinyl leukotriene receptor 1 in patients with bronchial asthma
Source: Annual Congress 2007 - Novel mediators of cellular pathology
Year: 2007