The “COLD-PCR-approach” for early and cost-effective detection of tyrosine kinase inhibitor resistance

F. Mairinger, C. Vollbrecht, A. Streubel, A. Roth, R. Walter, T. Mairinger (Essen, Cologne, Berlin, Germany)

Source: Annual Congress 2013 –Progress in bronchoscopy and pathology techniques for diagnosis of thoracic malignancies
Disease area: Thoracic oncology

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Mairinger, C. Vollbrecht, A. Streubel, A. Roth, R. Walter, T. Mairinger (Essen, Cologne, Berlin, Germany). The “COLD-PCR-approach” for early and cost-effective detection of tyrosine kinase inhibitor resistance. Eur Respir J 2013; 42: Suppl. 57, 5094

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
European mapping of EGFR mutation test and EGFR tyrosine kinase inhibitors availability in thoracic oncology
Source: International Congress 2015 – Quality management in lung cancer
Year: 2015


Met amplification induces an aggressive phenotype in EGFR tyrosine kinase inhibitors resistant non-small-cell lung cancer
Source: International Congress 2015 – New frontiers in biomedical research on thoracic tumours
Year: 2015

Novel two mechanisms for acquired EGFR-TKI resistance in lung cancer cells harboring EGFR activating mutation
Source: International Congress 2014 – Pathology and prognostic factors of thoracic tumours
Year: 2014

EGFR mutations determine EGFR-MET crosstalk and MET inhibition in lung cancer
Source: International Congress 2015 – Biomarkers, immunology and molecular pathology of lung cancer
Year: 2015

mRNA biomarker screening in pulmonary tumors showing neuroendocrine differentiation
Source: Annual Congress 2013 –Prognostic factors and subtyping of lung cancer
Year: 2013


Optimization of cfDNA routine use for NSCLC genomic alteration analysis
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016


CK2 enzyme affinity against c-myc424-434 substrate in human lung cancer tissue
Source: Annual Congress 2013 –Genetics and genomics of lung disease
Year: 2013

Proapoptotic effects of PAI-1 protein on lung and prostate cancer cells
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013


Lung adenocarcinoma with concomitant EGFR mutation and ALK rearrangement: Analysis of two cases and literature review
Source: International Congress 2016 – Basic science and case reports in lung cancer
Year: 2016


The utility of bronchoscopically acquired tissue for successful lung cancer molecular profiling (LC-MP)
Source: Annual Congress 2013 –Comfort, safety and effectiveness of bronchoscopy
Year: 2013


Significance of EGFR expression patterns in patients with non-small cell lung cancer – Evaluation on protein- and/or gene level?
Source: International Congress 2014 – Pathology and prognostic factors of thoracic tumours
Year: 2014


Clinical profile of newly diagnosed patients of non small cell carcinima with epidermal growth factor receptor positivity on oral tyrosine kinase inhibitor therapy
Source: Annual Congress 2013 –Systemic therapy of lung cancer and quality of life
Year: 2013


Automated target-FISH lung cancer detection (LCD) test of induced sputum
Source: International Congress 2015 – Developments in lung cancer diagnosis
Year: 2015


RT-PCR and IHC as the alternative methods for detection of ALK aberrations in NSCLC samples - The feasibility study
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015

The diagnostic puzzle of ALK rearrangement in lung cancer. A novel intron related abnormality
Source: Annual Congress 2013 –Biology and molecular pathology of lung cancer
Year: 2013



EGFR mutation diagnostic program for NSCLC patients in Poland between 2011-2014
Source: International Congress 2015 – Promising novel findings in translational pulmonary research
Year: 2015

Gefitinib versus erlotinib as first-line treatment in EGFR mutant advanced lung adenocarcinoma
Source: International Congress 2016 – Therapeutic trials in lung cancer
Year: 2016


MET genetic lesions in NSCLC are functional markers of early hematogenous spreading and radioresistance
Source: International Congress 2015 – Biomarkers, immunology and molecular pathology of lung cancer
Year: 2015


Investigate which PKC isoform play an important role in human lung cancer cells against TRAIL-induced apoptosis
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Expression and clinical significance of S100 calcium binding protein A2 in lung cancer
Source: International Congress 2016 – Prognostic variables in lung cancer II
Year: 2016