Serine and arginine-rich splicing factors as nuclear targets for TGF-beta1

O. Hallgren, J. Malmström, L. Malmström, A. Andersson-Sjöland, M. Wildt, E. Tufvesson, G. Marko-Varga, G. Westergren-Thorsson (Lund, Sweden; Zurich, Lund, Switzerland)

Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Session: Growth factors at the crossroads of acute and chronic inflammation
Session type: Poster Discussion
Number: 4889
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
O. Hallgren, J. Malmström, L. Malmström, A. Andersson-Sjöland, M. Wildt, E. Tufvesson, G. Marko-Varga, G. Westergren-Thorsson (Lund, Sweden; Zurich, Lund, Switzerland). Serine and arginine-rich splicing factors as nuclear targets for TGF-beta1. Eur Respir J 2013; 42: Suppl. 57, 4889

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Potential role of SPARC, a downstream mediator of TGF-b in chronic airways disease
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Secreted frizzled-related protein 1 (Sfrp1) as key mediator of growth-factor induced invasion
Source: International Congress 2014 – ILDs: connective tissue disease
Year: 2014

Endothelin-1 induced connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Serum B cell activating factor (BAFF) as a prognostic biomarker in interstitial lung diseases associated with connective tissue diseases
Source: International Congress 2014 – ILDs: connective tissue disease
Year: 2014

The effects of tobramycin on pulmonary fibroblast function
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

SMAD3 regulation contributes to lung vascular remodeling in pulmonary arterial hypertension
Source: International Congress 2015 – Respiratory translational research: novel mechanisms, diagnostic markers and Space Odyssey
Year: 2015



The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
Source: International Congress 2014 – ILDs 1
Year: 2014


Uncoupling the pro-fibrotic effects of TGF-beta1 versus tissue hardening in lung fibroblasts
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

Inhibition of collagen cross-links by novel LOXL2 selective inhibitors in an in-vitro model of fibroblastic foci of IPF
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Matrix metalloproteinase- 9 (MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) as non-invasive biomarkers of remodelling in asthma
Source: International Congress 2015 – Phenotyping asthma with biomarkers
Year: 2015


B cell activating factor belonging to the TNF family might be a useful biomarker in interstitial lung diseases associated with connective tissue diseases
Source: Annual Congress 2013 –Connective tissue disease and interstitial lung disease
Year: 2013


ATF3 regulates PINK1 transcription in lung epithelial cells of the aging lung
Source: International Congress 2016 – Repair pathways: from lung development to ageing of the lung
Year: 2016

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

HDAC inhibitors may regulate EMT and surfactant protein C in human alveolar epithelial cells
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015

Targeting ASK1 in preventing airway smooth muscle growth: Implications for airway remodeling in COPD
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016


Fibroblast growth factor 9 (FGF9) modulates the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014

Link between airway inflammation and remodeling: TNFα induces airway smooth muscle cell proliferation via an ET1/GMCSF/IL6 network
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

FGF-2 modulates human airway smooth muscle contractile protein expression and cell stiffness
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Targetingpyruvate kinase M2 isoform inhibits proliferation of human lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

p53 dysfunction increased mitochondrial biogenesis and bronchial smooth muscle cell proliferation in asthma
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015