Histone deacetylase inhibitor panobinostat reduces hypoxia-related cisplatin resistance in NSCLC cells by HDAC-mediated Hifalpha destabilization

C. Fischer, K. Leithner, C. Wohlkoenig, E. Stacher, A. Olschewski, H. Olschewski, A. Hrzenjak (Graz, Austria)

Source: Annual Congress 2013 –Basic research on lung cancer
Session: Basic research on lung cancer
Session type: Poster Discussion
Number: 3105
Disease area: Thoracic oncology

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Fischer, K. Leithner, C. Wohlkoenig, E. Stacher, A. Olschewski, H. Olschewski, A. Hrzenjak (Graz, Austria). Histone deacetylase inhibitor panobinostat reduces hypoxia-related cisplatin resistance in NSCLC cells by HDAC-mediated Hifalpha destabilization. Eur Respir J 2013; 42: Suppl. 57, 3105

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Comparison of anticancer effects of a novel histone deacetylase (HDAC) inhibitor CG200745 and SAHA in non-small lung cancer cells
Source: International Congress 2019 – Diagnostic procedures and biology of lung cancer
Year: 2019

SMYD3 links lysine methylation of MAP3K2 to ras-driven lung cancer
Source: International Congress 2015 – Cell biology of lung cancer and new biomarkers
Year: 2015


Possible role of nuclear receptor nr4a1 in hypoxia-induced cisplatin resistance
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Histone demethylation and acetylation are involved in the epigenetic regulation of epithelial-mesenchymal transition (EMT)
Source: Annual Congress 2013 –Novel mechanisms in lung injury
Year: 2013

RBM5 overexpression reverses acquired resistance to gefitinib in PC9/AB2 NSCLC cells
Source: International Congress 2016 – Late-breaking translational research in lung cancer
Year: 2016

Simvastatin overcomes gefitinib resistance in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptor via Akt/b-catenin signaling dependent down-regulation of survivin
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Glucocorticoid reduces pemetrexed sensitivity by mediating senescence-associated secretory phenotype in Bcl-2 dependent manner in non-small-cell lung cancer
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Histone deacetylase inhibition significantly augments human mesothelioma cellular response to chemotherapeutic agents
Source: Eur Respir J 2001; 18: Suppl. 33, 396s
Year: 2001

Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis
Source: Annual Congress 2012 - New insights in the pathology of lung cancer
Year: 2012

The role of HIF-1 pathway in non-small-cell lung cancer
Source: International Congress 2016 – Prognostic variables in lung cancer I
Year: 2016

Met amplification induces an aggressive phenotype in EGFR tyrosine kinase inhibitors resistant non-small-cell lung cancer
Source: International Congress 2015 – New frontiers in biomedical research on thoracic tumours
Year: 2015

Dihydroartemisinin combined with cisplatinum induced apoptosis and related mechanism research in human lung adenocarcinoma H1299 cells
Source: International Congress 2016 – Lung cancer and immune cells: friends or foes?
Year: 2016

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Source: International Congress 2016 – Basic science and case reports in lung cancer
Year: 2016

Cox-2 inhibitors in the treatment of small cell lung cancer patients
Source: International Congress 2015 – Advances in the therapy of lung cancer
Year: 2015


Investigate which PKC isoform play an important role in human lung cancer cells against TRAIL-induced apoptosis
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Re-education of tumor-associated macrophages by modulating histone deacetylases in lung cancer
Source: ERS Lung Science Conference 2017
Year: 2017

LSC - 2017 - Re-education of tumor-associated macrophages by modulating histone deacetylases in lung cancer
Source: International Congress 2017 – Basic research in lung cancer: a scientific potpourri from genetic alterations to immune cells
Year: 2017

Translocation of beta-catenin into cytoplasm during TGFbeta-induced EMT is negatively regulated by phosphorylation of the PTEN C-terminus in lung cancers
Source: Annual Congress 2013 –Novel in vitro and animal models to study lung diseases
Year: 2013


TRAP1 downregulation could overcome gefitinib resistance in NSCLC via EMT reversal
Source: International Congress 2018 – Lung cancer: novel molecular markers and mechanisms
Year: 2018



Valproate–doxorubicin: promising therapy for progressing mesothelioma. A phase II study
Source: Eur Respir J 2011; 37: 129-135
Year: 2011