Targeting PI3KΔ or JAK in T-cells from COPD and severe asthma subjects reduces corticosteroid insensitive inflammatory responses

T. Southworth, J. Plumb, V. Gupta, I. Ramis, M. D. Lehner, D. Singh (Manchester, United Kingdom; Barcelona, Spain)

Source: Annual Congress 2013 –COPD: new markers of diseases
Session: COPD: new markers of diseases
Session type: Thematic Poster Session
Number: 611
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Southworth, J. Plumb, V. Gupta, I. Ramis, M. D. Lehner, D. Singh (Manchester, United Kingdom; Barcelona, Spain). Targeting PI3KΔ or JAK in T-cells from COPD and severe asthma subjects reduces corticosteroid insensitive inflammatory responses. Eur Respir J 2013; 42: Suppl. 57, 611

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Activation of MMP-9 in BAL is increased in COPD exacerbation independently of smoking, lung function, microbiology and treatment
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014

Bronchoalveolar lavage tryptase levels are correlated with type 2 airway inflammation in mild asthma
Source: International Congress 2015 – Systemic and airway biomarkers
Year: 2015


IL-17A in severe asthma, severe asthma with fungal sensitisation and ABPA
Source: International Congress 2015 – Phenotyping asthma with biomarkers
Year: 2015


Expression of markers of activation and chemokine receptors by bronchoalveolar lavage T-cells from subjects with asthma, eosinophilic bronchitis and normal controls
Source: Eur Respir J 2001; 18: Suppl. 33, 530s
Year: 2001

The use of bronchoalveolar lavage (BAL) to assess lower airways inflammation in asthma
Source: International Congress 2016 – Assessing lower airway inflammation with different tools
Year: 2016


Pulmonary and systemic inflammation in patients with AECOPD
Source: Annual Congress 2013 –COPD: new markers of diseases
Year: 2013

Are there differences in the bronchoalveolar lavage (BAL) cytokine profile in children with and without allergic asthma?
Source: International Congress 2014 – More paediatric asthma
Year: 2014

Characterization of an acute influenza infection in a murine model of allergic asthma and responses to corticosteroid
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Higher doses of inhaled steroid are associated with bacterial bronchitis in children with severe therapy resistant asthma (STRA)
Source: International Congress 2016 – Paediatric asthma: from amniotic fluid to dirty streets
Year: 2016


Acute exacerbations in COPD patients are associated with increased levels of hyaluronic acid and heparan sulfate in BAL
Source: International Congress 2014 – Translational studies in COPD
Year: 2014

Involvement of the JAK-STAT3 pathway in a lipopolysaccharide-induced rat model of airway inflammation
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Sputum induction elicits different peripheral airways responses in healthy subjects, asthma and allergic rhinitis patients
Source: International Congress 2015 – Clincal aspects of asthma: monitoring and mechanisms
Year: 2015

Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects
Source: Eur Respir J 2006; 28: 513-522
Year: 2006



Local application of FTY720 to the lung abrogates experimental asthma by altering myeloid dendritic cell function
Source: Annual Congress 2006 - Towards understanding the pathogenesis of asthma
Year: 2006


Repeated lipopolysaccharide stimulation causes corticosteroid insensitive inflammation in lung via phosphoinositide-3-kinase δ signaling
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation
Source: Eur Respir J 2013; 41: 396-401
Year: 2013



Studies on apoptosis of alveolar lymphocytes (AL) in exogenous allergic alveolitis (EAA)
Source: International Congress 2016 – ILD pathogenesis
Year: 2016

Effects of cyclosporin H on airway inflammatory responses induced by mitochondrial damage-associated molecular patterns
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

Airway dendritic cell phenotypes in inflammatory diseases of the human lung
Source: Eur Respir J 2007; 30: 878-886
Year: 2007



Lung microbiome is associated with asthma severity in fungal associated asthma
Source: International Congress 2015 – Phenotyping asthma with biomarkers
Year: 2015