IL-4/IL-13 promote Th2-type inflammatory changes in airway smooth muscle and induce myofibroblast differentiation

G. Vass, S. Kierstein, R. Syed, V. Krymskaya, R. A. Panettieri, A. Haczku (Budapest, Hungary; Philadelphia, United States Of America)

Source: Annual Congress 2005 - Cellular mechanisms of inflammatory lung diseases
Session: Cellular mechanisms of inflammatory lung diseases
Session type: Poster Discussion
Number: 1445
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. Vass, S. Kierstein, R. Syed, V. Krymskaya, R. A. Panettieri, A. Haczku (Budapest, Hungary; Philadelphia, United States Of America). IL-4/IL-13 promote Th2-type inflammatory changes in airway smooth muscle and induce myofibroblast differentiation. Eur Respir J 2005; 26: Suppl. 49, 1445

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Eosinophils promote airway smooth muscle cells differentiation to the contractile phenotype in asthma
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Attenuation of human bronchial smooth muscle cell proliferation by rapamycin in Th2 cytokine dominant status
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

Contribution of bronchial smooth muscle to inflammation
Source: Annual Congress 2005 - Role of the bronchial smooth muscle in regulating airway disease
Year: 2005

Responses of bronchial smooth muscle to inflammation and disease
Source: Annual Congress 2005 - Role of the bronchial smooth muscle in regulating airway disease
Year: 2005

IgE-induced pro-inflammatory extracellular matrix composition in airway smooth muscle cells is prevented by omalizumab
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012


Effects of IL-5 and IL-13 on human airway smooth muscle migration, proliferation and cytokine synthesis
Source: Eur Respir J 2005; 26: Suppl. 49, 128s
Year: 2005

Rhinovirus-induced IL-33 expression in asthmatic airway smooth muscle cells is TLR3-dependent and involves activation of TAK1
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016

In vivo allergen-activated inflammatory eosinophils reduced airway smooth muscle cells apoptosis in allergic asthma patients
Source: Virtual Congress 2021 – New insights into the airway immunology of lung disease
Year: 2021


Smooth-muscle-derived WNT-5A drives allergen-induced remodelling and Th2 type inflammation
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018

Eotaxin/CCL11 inhibits proliferation of human airway smooth muscle cells
Source: Eur Respir J 2005; 26: Suppl. 49, 127s
Year: 2005

Platelets induce airway smooth muscle cell proliferation through mechanisms dependent on ROS and 5-LOX metabolites
Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms
Year: 2005


Omalizumab inhibits IgE-induced cytokine secretion by human airway smooth muscle cells
Source: Annual Congress 2008 - Basic science in asthma and COPD
Year: 2008

LSC Abstract – Eosinophils enhance WNT-5a and TGF-β1 genes expression in airway smooth muscle cells and promote their proliferation in asthma
Source: International Congress 2016 – Clinical characteristics of asthma
Year: 2016

TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells
Source: ERJ Open Res, 6 (4) 00147-2020; 10.1183/23120541.00147-2020
Year: 2020



Upregulation of airway smooth muscle (ASM) cell apoptosis may limit ASM growth during airway remodeling in experimental asthma
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Interferon-γ-pretreated dendritic cells induced dual Th1 and Th2 responses and failed to prevent development of allergic airway inflammation
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma
Source: Annual Congress 2012 - Asthma and COPD: understanding through mechanisms
Year: 2012

α-4 integrin blockade modulates airway smooth muscle (ASM) growth induced by activated, antigen-specific CD4+T cells
Source: Annual Congress 2009 - Airways remodelling
Year: 2009

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013