Pharmacological induction of HDAC activity restores steroid function in macrophages subjected to oxidative stress

P. Kirkham, K. Meja, J. Marwick (Horsham, United Kingdom)

Source: Annual Congress 2005 - New perspectives in asthma treatment
Session: New perspectives in asthma treatment
Session type: Poster Discussion
Number: 1392
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. Kirkham, K. Meja, J. Marwick (Horsham, United Kingdom). Pharmacological induction of HDAC activity restores steroid function in macrophages subjected to oxidative stress. Eur Respir J 2005; 26: Suppl. 49, 1392

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Erythromycin restores HDAC2 levels diminished under oxidative and inflammatory stress in vitro and in vivo
Source: Annual Congress 2008 - Pathogenesis and treatment of asthma and COPD
Year: 2008

Restoration of HDAC-2 activity by curcumin & theophylline in cells exposed to oxidative stress through alteration of covalent modifications
Source: Eur Respir J 2006; 28: Suppl. 50, 523s
Year: 2006

iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Effect of PDE4 inhibitors on MAPK activation and IL-8 production on A549 cells following the induction of oxidative stress
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005

Formoterol restores oxidative stress-induced corticosteroid insensitivity via activation of protein phosphatase PP2A
Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Year: 2012


DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells
Source: International Congress 2017 – Translational studies of lung disease
Year: 2017

Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction
Source: Virtual Congress 2020 – Idiopathic pulmonary fibrosis and interstitial lung disease: progression, genes and more
Year: 2020

Oxidative stress-mediated decrease in histone deacetylase activity is attenuated by N-acetyl-L-cysteine but not by Iκ-B kinase inhibition in alveolar epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 29s
Year: 2004

Modulation of oxidative stress pathway by arginase inhibition: Evaluation in an animal model of chronic pulmonary inflammation
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010


High proteasome activity and absence of NF-kB activation in cystic fibrosis cell culture and CF KO mouse models in response to oxidative stress
Source: Eur Respir J 2005; 26: Suppl. 49, 403s
Year: 2005

Defect of sirtuin, an anti-aging molecule, reduces anti-oxidative stress capacity in THP-1 cell line
Source: Annual Congress 2010 - Macrophages: cell biology and disease-specific characteristics
Year: 2010


Physical stress modulates distal lung tissue mechanics, inflammation and remodelling associated to iNOS and oxidative stress activation
Source: Annual Congress 2008 - Pathophysiology of respiratory diseases
Year: 2008


The effect of antioxidant tetrapeptide UPF1 on enzymes involved in glutathione metabolism in human bronchial epithelial cells exposed to oxidative stress
Source: Annual Congress 2010 - Novel insights into the pathophysiology of asthma and COPD
Year: 2010

Repeated stress modulates lung tissue mechanics and induces pulmonary inflammation, remodelling and oxidative stress pathway activation in guinea pigs
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Effect of oxidative stress on amplified inflammation via dissociation of co-repressors and HDAC2
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


Oxidative stress alters histone phosphorylation in monocytes and alveolar macrophages
Source: Annual Congress 2009 - Airway inflammation and host defence
Year: 2009

Curcumin restores glucocorticoid function and inhibits cigarette smoke-mediated IL-8 release in oxidant stressed monocytic U937 cells
Source: Eur Respir J 2005; 26: Suppl. 49, 215s
Year: 2005

Enhancement of the airway epithelial cell response to dsRNA by oxidative stress
Source: Annual Congress 2008 - Airway cell biology
Year: 2008

The effects of Nrf2 activators and oxidative stress on COPD alveolar macrophages
Source: Virtual Congress 2020 – Scientific advances in airway pharmacology
Year: 2020


N-acetylcysteine attenuates the stress oxidative induced by chronic paraquat toxicity in different tissues
Source: Eur Respir J 2006; 28: Suppl. 50, 650s
Year: 2006