Involvement of proteasome inhibition and p53 accumulation in epithelial apoptosis of lung injury

T. Maeyama, M. Yamada, K. Kuwano, N. Nakashima, M. Yoshimi, N. Hagimoto, Y. Kaneko, J. Fukumoto, Y. Nakanishi (Fukuoka, Japan)

Source: Annual Congress 2005 - From molecules to patients: mechanisms of lung injury, fibrosis and cancer
Session: From molecules to patients: mechanisms of lung injury, fibrosis and cancer
Session type: Thematic Poster Session
Number: 723
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Maeyama, M. Yamada, K. Kuwano, N. Nakashima, M. Yoshimi, N. Hagimoto, Y. Kaneko, J. Fukumoto, Y. Nakanishi (Fukuoka, Japan). Involvement of proteasome inhibition and p53 accumulation in epithelial apoptosis of lung injury. Eur Respir J 2005; 26: Suppl. 49, 723

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The inhibition of fas-mediated apoptosis of lung alveolar epithelial cells by cyclin dependent kinase inhibitor p21
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Induction of apoptosis in murine alveolar epithelial cells by a proteasome inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

TGFß1-induces resistance to apoptosis in human lung myofibroblasts via TRPA1 downregulation
Source: International Congress 2019 – Translational aspects of idiopathic pulmonary fibrosis
Year: 2019

Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis.
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

GSK-3 inhibition suppresses lung cancer cell survival, metastasis and proliferation through down-regulation the phosphorylation sites of CAP1
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

miR-184 mediates hyperoxia-induced injury by targeting cell death and angiogenesis signalling pathways in the developing lung
Source: Eur Respir J, 58 (3) 1901789; 10.1183/13993003.01789-2019
Year: 2021



Fas activation impairs the alveolar epithelial function in mice by mechanisms involving apoptosis
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

Retinoic acid abrogation of TNF-alpha-induced growth arrest in lung alveolar epithelial cells is linked to p21 (CIP1) downregulation
Source: Eur Respir J 2001; 18: Suppl. 33, 477s
Year: 2001

iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Rapid activation of pro-apoptotic caspases and p21Waf1/Cip1 cleavage in zinc-depleted airway epithelial cells
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

VEGF prevents oxidant mediated apoptosis in epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 344s
Year: 2005

Caspase recruitment domain containing protein 9 suppresses non-small cell lung cancer proliferation and invasion via inhibiting MAPK/p38 pathway
Source: Virtual Congress 2020 – Molecular alterations and immunology in lung cancer
Year: 2020

MMP regulation of apoptosis via Fas-pathway in human airway epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 77s
Year: 2003

Functional expressions of EGFP/LKB1 and its kinase domain induced apoptosis and enhanced chemosensitivity in lung cancer cell lines
Source: Eur Respir J 2004; 24: Suppl. 48, 5s
Year: 2004

Inhibition of neutrophil apoptosis by sphingosin-1-phopsphate through the activation of neutral sphingomyelinase in acute lung injury
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Involvement of Fas/FasL system in gemcitabine-induced lung cancer cell killing
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010

Autophagy induces cytoprotection in cisplatin-treated lung cancer cells
Source: Annual Congress 2010 - Pathology of lung cancer
Year: 2010

Upregulation of the production of TGF-β and IL-4 and downregulation of IL-6 by apoptotic human bronchial epithelial cells: possible role in regulation of epithelial repair following acute lung injury
Source: Eur Respir J 2001; 18: Suppl. 33, 477s
Year: 2001