Biology of gene-environment interactions in the lung, Estoril 2010

The Lung Science Conference is at the forefront of basic and translational respiratory science and it is an essential event for budding respiratory researchers looking to boost their career.

Educational aims

To present the very best of international lung science research
To highlight new discoveries likely to impact on the future of respiratory medicine
To encourage debate and interaction between young postdoctoral scientists and established investigators

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Oral presentation: Potential of ACE2 as a therapeutic target for pulmonary hypertension M. Raizada (Gainesville, United States of America)
Oral presentation: New insights and therapeutically strategies for emphysema and COPD: the growth factors KGF and TGF?-1 A. Ö. Yildirim, M. Vandana, G. John, B. Müller, H. Fehrenbach (Borstel, Germany)
Oral presentation: Epigenetic mechanism involved in smoke-induced persistent elevation of MUC5AC R. Wu, A. Loukoianov, S. Statt, P. Lee, P. Thai, M. Chang (Davis, United States of America)
Oral presentation: Exogenous administration of leptin restores the skewed inflammatory response in cigarette smoke-exposed ob/ob mice J.H.J. Vernooy, L. Zabeau, J. Tavernier, G.F. Joos, G.G. Brusselle, E.F.M. Wouters, K.R. Bracke (Ghent, Belgium)
Oral presentation: Genetic or pharmacologic inhibition of ATX stimulates LPS-induced pulmonary inflammation N. Oikonomou, A. Thanasopoulou, A. Kotanidou, G.D. Prestwich, V. Aidinis (Salt Lake City, United States of America)
Oral presentation: SOD3 protects cigarette smoke-induced emphysema associated with reduction of extracellular matrix fragmentation in mice H. Yao, G. Arunachalam, S. Chung, J. Hwang, I. Sundar, V. Kinnula, J. Crapo, I. Rahman (Denver, Denver)
Genes, mechanisms and new therapies for asthma W. Cookson (London, United Kingdom)
Oral presentation: Role of B-lymphocytes in a mouse model of chemical-induced asthma Innate immunity and the development of atopy V. De Vooght, K. Luyts, S. Haenen, B. Nemery, P.H.M. Hoet, J.A.J. Vanoirbeek (Leuven, Belgium)
Innate immunity and the development of atopy T. Sigsgaard (Aarhus, Denmark)
Oral presentation: Altered airway epithelial gene expression determines the lung remodeling response to environmental allergens; role of activin L. Gregory, S. Pegorier, S. Mathie, C.P. Jones, C. Lloyd (London, United Kingdom)
Genetics of childhood versus adult asthma: common and unique factors M. Kabesch (Hannover, Germany)
Oral presentation: Surfactant protein-B 121ins2 heterozygosity, reduced pulmonary function and COPD in smokers M. Bækvad-Hansen, M. Dahl, A. Tybjærg-Hansen, B.G. Nordestgaard (Copenhagen, Denmark)
Oral presentation: Gene-gene interaction between ITGB3 and TLR2 in sensitization to mold allergens among adults with asthma L.A.M. Smit, E. Bouzigon, J. Bousquet, G. Doekes, N. Le Moual, R. Nadif, I. Pin, F. Demenais, F. Kauffmann, V. Siroux (Grenoble, France)
Oral presentation: Vitamin D binding protein is functionally important in airway infections A. Wood, C. Bassford, S. Rathnam, P. Rajesh, R. Stockley, D. Thickett (Birmingham, United Kingdom)
Oral presentation: Role of HIF-1? on airway remodelling induced by house dust mite C.P. Jones, S.M. Rankin, C.M. Lloyd (London, United Kingdom)
Oral presentation: Role of neutrophil serine proteases in the pathogenesis of cigarette smoke-induced emphysema N. Guyot, J. Wartelle, A. Belaaouaj (Reims, France)
Oral presentation: Inhibition of innate host defense in airway epithelial cells by cigarette smoke in an in vitro infection model caused by suppression of NF-kB activation C. Herr, C. Beisswenger, C. Vogelmeier, R. Bals (Marburg, Germany)
Genetic basis of idiopathic interstitial pneumonia D. Schwartz (Denver, United States of America)
Oral presentation: Protease-activated receptor-2 plays a pivotal role in pulmonary fibrosis by inducing myofibroblast differentiation and tissue factor up-regulation K. Borensztajn, P. Bresser, J. von der Thusen, C. van der Loos, B. van der Blink, M. den Bakker, J. Daalhuisen, A. Groot, M. Peppelenbosch, A. Spek (Groningen, Netherlands)
Targeting CFTR as a therapy for cystic fibrosis M. Amaral (Lisbon, Portugal)
Oral presentation: Neutrophil elastase plays a dual role in host lung defense against Pseudomonas aeruginosa infection J. Wartelle, R. Benabid, N. Guyot, A. Belaaouaj (Reims, France)
Poster Presentation - abstracts