December

Lung cancer in pulmonary fibrosis: no room for nihilism! Bruno Crestani, Martin Kolb Eur Respir J, 60 (6) 2201946; 10.1183/13993003.01946-2022
How a fibroblast ages: a role for bone morphogenetic protein 4 in protecting lung fibroblasts from senescence in pulmonary fibrosis Laszlo Farkas, Jeffrey C. Horowitz, Ana L. Mora Eur Respir J, 60 (6) 2201702; 10.1183/13993003.01702-2022
COPD detection in lung cancer screening programmes: “hitting two birds with one stone” Juan P. de-Torres, Bartolome R. Celli Eur Respir J, 60 (6) 2201294; 10.1183/13993003.01294-2022
Chymase-1: a “MAST”-er switch in COPD? Corrine R. Kliment, Reinoud Gosens Eur Respir J, 60 (6) 2201356; 10.1183/13993003.01356-2022
The SOX17 phenotype in pulmonary arterial hypertension: lessons for pathobiology and clinical management Jurjan Aman, Nicholas W. Morrell, Christopher J. Rhodes, Martin R. Wilkins, Harm Jan Bogaard Eur Respir J, 60 (6) 2201438; 10.1183/13993003.01438-2022
A leap towards personalised therapy of acute lung injury Martin Witzenrath, Tobias Welte Eur Respir J, 60 (6) 2201808; 10.1183/13993003.01808-2022
Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19? David H. Dockrell, Clark D. Russell, Brian McHugh, Rupsha Fraser Eur Respir J, 60 (6) 2201521; 10.1183/13993003.01521-2022
Contributions to simplifying the global interpretation of spirometry: high quality spirometry data from Asia Arnulf Langhammer Eur Respir J, 60 (6) 2201608; 10.1183/13993003.01608-2022
Inspiratory hyperoxia: a new way to prevent metastasis through metabolism reprogramming in non-small cell lung cancer Beatrice Eymin Eur Respir J, 60 (6) 2201357; 10.1183/13993003.01357-2022
Nintedanib plus chemotherapy for nonsmall cell lung cancer with idiopathic pulmonary fibrosis: a randomised phase 3 trial Kohei Otsubo, Junji Kishimoto, Masahiko Ando, Hirotsugu Kenmotsu, Yuji Minegishi, Hidehito Horinouchi, Terufumi Kato, Eiki Ichihara, Masashi Kondo, Shinji Atagi, Motohiro Tamiya, Satoshi Ikeda, Toshiyuki Harada, Shinnosuke Takemoto, Hidetoshi Hayashi, Keita Nakatomi, Yuichiro Kimura, Yasuhiro Kondoh, Masahiko Kusumoto, Kazuya Ichikado, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Yoichi Nakanishi, Isamu Okamoto Eur Respir J, 60 (6) 2200380; 10.1183/13993003.00380-2022
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts Ruijuan Guan, Liang Yuan, Jingpei Li, Jian Wang, Ziying Li, Zhou Cai, Hua Guo, Yaowei Fang, Ran Lin, Wei Liu, Lan Wang, Qiuyu Zheng, Jingyi Xu, You Zhou, Jing Qian, Mingjing Ding, Jieping Luo, Yuanyuan Li, Kai Yang, Dejun Sun, Hongwei Yao, Jianxing He, Wenju Lu Eur Respir J, 60 (6) 2102307; 10.1183/13993003.02307-2021
Detection of COPD in the SUMMIT Study lung cancer screening cohort using symptoms and spirometry Sophie Tisi, Jennifer L. Dickson, Carolyn Horst, Samantha L. Quaife, Helen Hall, Priyam Verghese, Kylie Gyertson, Vicky Bowyer, Claire Levermore, Anne-Marie Mullin, Jonathan Teague, Laura Farrelly, Arjun Nair, Anand Devaraj, Allan Hackshaw, John R. Hurst, Sam M. Janes Eur Respir J, 60 (6) 2200795; 10.1183/13993003.00795-2022
Adverse roles of mast cell chymase-1 in COPD Gang Liu, Andrew G. Jarnicki, Keshav R. Paudel, Wenying Lu, Ridhima Wadhwa, Ashleigh M. Philp, Hannelore Van Eeckhoutte, Jacqueline E. Marshall, Vamshikrishna Malyla, Angelica Katsifis, Michael Fricker, Nicole G. Hansbro, Kamal Dua, Nazanin Z. Kermani, Mathew S. Eapen, Angelica Tiotiu, K. Fan Chung, Gaetano Caramori, Ken Bracke, Ian M. Adcock, Sukhwinder S. Sohal, Peter A. Wark, Brian G. Oliver, Philip M. Hansbro Eur Respir J, 60 (6) 2101431; 10.1183/13993003.01431-2021
An emerging phenotype of pulmonary arterial hypertension patients carrying SOX17 variants David Montani, Benoit Lechartier, Barbara Girerd, Mélanie Eyries, Maria-Rosa Ghigna, Laurent Savale, Xavier Jaïs, Andrei Seferian, Mitja Jevnikar, Athénais Boucly, Marianne Riou, Julie Traclet, Ari Chaouat, Maryline Levy, Jerome Le Pavec, Elie Fadel, Frédéric Perros, Florent Soubrier, Martine Remy-Jardin, Olivier Sitbon, Damien Bonnet, Marc Humbert Eur Respir J, 60 (6) 2200656; 10.1183/13993003.00656-2022
Inhaled seralutinib exhibits potent efficacy in models of pulmonary arterial hypertension Anna Galkin, Ravikumar Sitapara, Bryan Clemons, Eduardo Garcia, Michael Kennedy, David Guimond, Laura L. Carter, Ashley Douthitt, Robin Osterhout, Aneta Gandjeva, Deborah Slee, Luisa Salter-Cid, Rubin M. Tuder, Lawrence S. Zisman Eur Respir J, 60 (6) 2102356; 10.1183/13993003.02356-2021
A biomarker assay to risk-stratify patients with symptoms of respiratory tract infection Shahid Husain, Andrew T. Sage, Lorenzo del Sorbo, Marcelo Cypel, Tereza Martinu, Stephen C. Juvet, Andrea Mariscal, Julie Wright, Bonnie T. Chao, Alaa A. Shamandy, S. Hossein Mousavi, Jin Ma, Bo Wang, Jerome Valero, Mingyao Liu, Megan Landes, Sharaniyaa Balachandran, Kimberley Hudson, Michelle Ngai, Marialessia Capuano, Maria Gelardi, Enrico Lupia, Daniel R. Marinowic, Frederico O. Friedrich, Carine R.R. Schmitz, Leticya S.M. dos Santos, Florencia M. Barbe-Tuana, Marcus H. Jones, Kevin C. Kain, Tony Mazzulli, Sam Sabbah, Shaf Keshavjee Eur Respir J, 60 (6) 2200459; 10.1183/13993003.00459-2022
Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients Justin de Brabander, Erik Duijvelaar, Job R. Schippers, Patrick J. Smeele, Hessel Peters-Sengers, Jan Willem Duitman, Jurjan Aman, Harm Jan Bogaard, Tom van der Poll, Lieuwe D.J. Bos Eur Respir J, 60 (6) 2200780; 10.1183/13993003.00780-2022
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages Katja Hönzke, Benedikt Obermayer, Christin Mache, Diana Fathykova, Mirjana Kessler, Simon Dökel, Emanuel Wyler, Morris Baumgardt, Anna Löwa, Karen Hoffmann, Patrick Graff, Jessica Schulze, Maren Mieth, Katharina Hellwig, Zeynep Demir, Barbara Biere, Linda Brunotte, Angeles Mecate-Zambrano, Judith Bushe, Melanie Dohmen, Christian Hinze, Sefer Elezkurtaj, Mario Tönnies, Torsten T. Bauer, Stephan Eggeling, Hong-Linh Tran, Paul Schneider, Jens Neudecker, Jens C. Rückert, Kai M. Schmidt-Ott, Jonas Busch, Frederick Klauschen, David Horst, Helena Radbruch, Josefine Radke, Frank Heppner, Victor M. Corman, Daniela Niemeyer, Marcel A. Müller, Christine Goffinet, Ronja Mothes, Anna Pascual-Reguant, Anja Erika Hauser, Dieter Beule, Markus Landthaler, Stephan Ludwig, Norbert Suttorp, Martin Witzenrath, Achim D. Gruber, Christian Drosten, Leif-Erik Sander, Thorsten Wolff, Stefan Hippenstiel, Andreas C. Hocke Eur Respir J, 60 (6) 2102725; 10.1183/13993003.02725-2021
Reference equations for evaluation of spirometry function tests in South Asia, and among South Asians living in other countries Wei Yee Leong, Ananya Gupta, Mehedi Hasan, Sara Mahmood, Samreen Siddiqui, Sajjad Ahmed, Ian Y. Goon, Marie Loh, Theresia H. Mina, Benjamin Lam, Yik Weng Yew, Joanne Ngeow, Jimmy Lee, Eng Sing Lee, Elio Riboli, Paul Elliott, Geak Poh Tan, Sanjay H. Chotirmall, Ananda R. Wickremasinghe, Jaspal S. Kooner, Khadija I. Khawaja, Prasad Katulanda, Malay K. Mridha, Sujeet Jha, Anjana Ranjit Mohan, Guha Pradeepa, Anuradhani Kasturiratne, John C. Chambers Eur Respir J, 60 (6) 2102962; 10.1183/13993003.02962-2021
Benefits of specialist severe asthma management: demographic and geographic disparities Charlene Redmond, Liam G. Heaney, Rekha Chaudhuri, David J. Jackson, Andrew Menzies-Gow, Paul Pfeffer, John Busby Eur Respir J, 60 (6) 2200660; 10.1183/13993003.00660-2022
An observational study to determine the relationship between cough frequency and markers of inflammation in severe asthma Joshua Holmes, Lorcan P.A. McGarvey, Surinder S. Birring, Hannah Fletcher, Liam G. Heaney Eur Respir J, 60 (6) 2103205; 10.1183/13993003.03205-2021
Airway autoantibodies are determinants of asthma severity Brittany Salter, Nan Zhao, Kiho Son, Nadia Suray Tan, Anna Dvorkin-Gheva, Katherine Radford, Nicola LaVigne, Chynna Huang, Melanie Kjarsgaard, Quan-Zhen Li, Konstantinos Tselios, Hui Fang Lim, Nader Khalidi, Parameswaran Nair, Manali Mukherjee Eur Respir J, 60 (6) 2200442; 10.1183/13993003.00442-2022
Inspiratory hyperoxia suppresses lung cancer metastasis through a MYC/SLC1A5-dependent metabolic pathway Xiucheng Liu, Hao Qin, Zheng Li, Yin Lv, Shoujie Feng, Wei Zhuang, Xiaoyu Quan, Chen Guo, Chang Chen, Hao Zhang Eur Respir J, 60 (6) 2200062; 10.1183/13993003.00062-2022
Increasing physical activity in severe asthma: a systematic review and meta-analysis Rebecca F. McLoughlin, Vanessa L. Clark, Paola D. Urroz, Peter G. Gibson, Vanessa M. McDonald Eur Respir J, 60 (6) 2200546; 10.1183/13993003.00546-2022
The role of circular RNAs in pulmonary hypertension Md Khadem Ali, Katharina Schimmel, Lan Zhao, Chun-Kan Chen, Kamal Dua, Mark R. Nicolls, Edda Spiekerkoetter Eur Respir J, 60 (6) 2200012; 10.1183/13993003.00012-2022
Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R. Davies, Lareb S.N. Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G. Jones, Matthew Loxham, Jane S. Lucas, Hywel Morgan, Marta Polak, Karl J. Staples, Emily J. Swindle, Liku Tezera, Alastair Watson, Tom M.A. Wilkinson Eur Respir J, 60 (6) 2200455; 10.1183/13993003.00455-2022
Rectal organoid-guided CFTR modulator therapy restores lung function in a cystic fibrosis patient with the rare 1677delTA/R334W genotype Georgia Mitropoulou, Nathalie Brandenberg, Sylke Hoehnel, Camilla Ceroni, Zisis Balmpouzis, Sylvain Blanchon, Gian Dorta, Alain Sauty, Angela Koutsokera Eur Respir J, 60 (6) 2201341; 10.1183/13993003.01341-2022
The effect of regular, low-dose, sustained-release morphine on routine physical activity in people with persistent breathlessness: a hypothesis-generating study Diana H. Ferreira, Miriam J. Johnson, Daisy J.A. Janssen, Magnus Ekström, David C. Currow Eur Respir J, 60 (6) 2201484; 10.1183/13993003.01484-2022
Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care Samiksha Ghimire, Deni Iskandar, Roelina van der Borg-Boekhout, Marina Zenina, Mathieu S. Bolhuis, Huib A.M. Kerstjens, Marieke van Rossum, Daan J. Touw, Tanja R. Zijp, Job F.M. van Boven, Onno W. Akkerman Eur Respir J, 60 (6) 2201690; 10.1183/13993003.01690-2022
Evaluation of the Global Lung Function Initiative 2012 reference values for spirometry in China: a national cross-sectional study Feilong Wang, Kun Wang, Cole Bowerman, Hogne Ulla, Jiaxing Sun, Marko Topalovic, Sanja Stanojevic, Qiang Li Eur Respir J, 60 (6) 2200490; 10.1183/13993003.00490-2022
The aminoglycoside-modifying enzyme Eis2 represents a new potential in vivo target for reducing antimicrobial drug resistance in Mycobacterium abscessus complex Nicola Ivan Lorè, Fabio Saliu, Andrea Spitaleri, Daniel Schäfle, Francesca Nicola, Daniela Maria Cirillo, Peter Sander Eur Respir J, 60 (6) 2201541; 10.1183/13993003.01541-2022
Ventilation and tumour spread: still a pending matter Liu Zhang, Fang Ying Lu, Shao Guang Huang, Qing Yun Li Eur Respir J, 60 (6) 2201674; 10.1183/13993003.01674-2022
Reply to: Ventilation and tumour spread: still a pending matter Inés López-Alonso, Antonio Fueyo, Guillermo M. Albaiceta Eur Respir J, 60 (6) 2201826; 10.1183/13993003.01826-2022
Broadening concepts of core pathobiology in various aspects of COPD development Eugene H. Walters, Shakti Shukla, Chis Ward Eur Respir J, 60 (6) 2201531; 10.1183/13993003.01531-2022
Reply to: Broadening concepts of core pathobiology in various aspects of COPD development Feng Xu, Dragos Vasilescu, Wan Tan, Jim Hogg, Tillie-Louise Hackett Eur Respir J, 60 (6) 2201796; 10.1183/13993003.01796-2022
U-BIOPRED/BIOAIR proteins: inflammation or infection? David L. Hahn, Wilmore Webley Eur Respir J, 60 (6) 2200571; 10.1183/13993003.00571-2022
Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection? Maria Sparreman Mikus, Johan Kolmert, Lars I. Andersson, Sven-Erik Dahlén, Anna James Eur Respir J, 60 (6) 2201795; 10.1183/13993003.01795-2022
Pleuroparenchymal fibroelastosis: so many unmet needs Philippe Bonniaud, Vincent Cottin, Guillaume Beltramo Eur Respir J, 60 (6) 2201798; 10.1183/13993003.01798-2022
Oh NO! Loss of PHD2 leads to “radical” changes in the lung vasculature Mark L. Ormiston, Robert P. Jankov, Duncan J. Stewart Eur Respir J, 60 (6) 2201776; 10.1183/13993003.01776-2022
Utility of whole genome sequencing in assessing risk and clinically relevant outcomes for pulmonary fibrosis David Zhang, Chad A. Newton, Binhan Wang, Gundula Povysil, Imre Noth, Fernando J. Martinez, Ganesh Raghu, David Goldstein, Christine Kim Garcia Eur Respir J, 60 (6) 2200577; 10.1183/13993003.00577-2022
Idiopathic pleuroparenchymal fibroelastosis: three-dimensional computed tomography assessment of upper-lobe lung volume Atsuki Fukada, Yuzo Suzuki, Kazutaka Mori, Masato Kono, Hirotsugu Hasegawa, Dai Hashimoto, Koshi Yokomura, Shiro Imokawa, Yuko Tanaka, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Yoshihisa Fujino, Hidenori Nakamura, Takafumi Suda Eur Respir J, 60 (6) 2200637; 10.1183/13993003.00637-2022
Endothelial PHD2 deficiency induces nitrative stress via suppression of caveolin-1 in pulmonary hypertension Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M. Zhu, Zhiyu Dai, You-Yang Zhao Eur Respir J, 60 (6) 2102643; 10.1183/13993003.02643-2021
Adrenal function recovery after durable oral corticosteroid sparing with benralizumab in the PONENTE study Andrew Menzies-Gow, Mark Gurnell, Liam G. Heaney, Jonathan Corren, Elisabeth H. Bel, Jorge Maspero, Timothy Harrison, David J. Jackson, David Price, Njira Lugogo, James Kreindler, Annie Burden, Alex de Giorgio-Miller, Sarai Faison, Kelly Padilla, Ubaldo J. Martin, Esther Garcia Gil Eur Respir J, 60 (6) 2103226; 10.1183/13993003.03226-2021
Green and blue spaces and lung function in the Generation XXI cohort: a life-course approach Diogo Queiroz Almeida, Inês Paciência, Carla Moreira, João Cavaleiro Rufo, André Moreira, Ana Cristina Santos, Henrique Barros, Ana Isabel Ribeiro Eur Respir J, 60 (6) 2103024; 10.1183/13993003.03024-2021
Ciliogenesis is intrinsically altered in COPD small airways Emilie Luczka-Majérus, Arnaud Bonnomet, Adeline Germain, Nathalie Lalun, Claire Kileztky, Jeanne-Marie Perotin, Gaëtan Deslée, Gonzague Delepine, Myriam Polette, Valérian Dormoy, Christelle Coraux Eur Respir J, 60 (6) 2200791; 10.1183/13993003.00791-2022
Smoking quantitatively increases risk for COVID-19 Fuquan Zhang, Ancha Baranova Eur Respir J, 60 (6) 2101273; 10.1183/13993003.01273-2021