May

The respiratory tract microbiome: moving from correlation to causation Richard Morton, Aran Singanayagam Eur Respir J, 59 (5) 2103079; 10.1183/13993003.03079-2021
Should we rewrite the natural history and prognosis of pulmonary Langerhans cell histiocytosis? Sergio Harari, Davide Elia Eur Respir J, 59 (5) 2200700; 10.1183/13993003.00700-2022
Targeting the nasty nestin to shoot lung fibrosis Olivier Burgy, Bruno Crestani, Philippe Bonniaud Eur Respir J, 59 (5) 2103146; 10.1183/13993003.03146-2021
Quality over quantity: the importance of collecting relevant samples to understand complex diseases Alen Faiz, Maarten van den Berge Eur Respir J, 59 (5) 2200418; 10.1183/13993003.00418-2022
ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations Alexander G. Mathioudakis, Fekri Abroug, Alvar Agusti, Sachin Ananth, Per Bakke, Konstantinos Bartziokas, Bianca Beghe, Andras Bikov, Thomas Bradbury, Guy Brusselle, Cordula Cadus, Courtney Coleman, Marco Contoli, Alexandru Corlateanu, Olga Corlateanu, Gerard J. Criner, Balazs Csoma, Alexander Emelyanov, Rosa Faner, Gustavo Fernandez Romero, Zeineb Hammouda, Peter Horváth, Arturo Huerta Garcia, Michael Jacobs, Christine Jenkins, Guy Joos, Olga Kharevich, Konstantinos Kostikas, Elena Lapteva, Zsofia Lazar, Joerg D. Leuppi, Carol Liddle, John Linnell, Alejandra López-Giraldo, Vanessa M. McDonald, Rune Nielsen, Alberto Papi, Isabel Saraiva, Galina Sergeeva, Agni Sioutkou, Pradeesh Sivapalan, Elizabeth Stovold, Hao Wang, Fuqiang Wen, Janelle Yorke, Paula R. Williamson, Jørgen Vestbo, Jens-Ulrik Jensen Eur Respir J, 59 (5) 2102006; 10.1183/13993003.02006-2021
Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD Lorna E. Latimer, Dumitru Constantin-Teodosiu, Bhavesh Popat, Despina Constantin, Linzy Houchen-Wolloff, Charlotte E. Bolton, Michael C. Steiner, Paul L. Greenhaff Eur Respir J, 59 (5) 2101507; 10.1183/13993003.01507-2021
Association of blood trihalomethane concentrations with asthma in US adolescents: nationally representative cross-sectional study Yang Sun, Peng-Fei Xia, Jing Xie, Vicente Mustieles, Yu Zhang, Yi-Xin Wang, Carmen Messerlian Eur Respir J, 59 (5) 2101440; 10.1183/13993003.01440-2021
Short-acting ß₂-agonist prescriptions are associated with poor clinical outcomes of asthma: the multi-country, cross-sectional SABINA III study Eric D. Bateman, David B. Price, Hao-Chien Wang, Adel Khattab, Patricia Schonffeldt, Angelina Catanzariti, Ralf J.P. van der Valk, Maarten J.H.I. Beekman Eur Respir J, 59 (5) 2101402; 10.1183/13993003.01402-2021
Association of early-life factors with prematurity-associated lung disease: prospective cohort study Kylie Hart, Michael Cousins, W. John Watkins, Sarah J. Kotecha, A. John Henderson, Sailesh Kotecha Eur Respir J, 59 (5) 2101766; 10.1183/13993003.01766-2021
Violence-related distress and lung function in two longitudinal studies of youth Kristina Gaietto, Yueh-Ying Han, Erick Forno, Leonard B. Bacharier, Wanda Phipatanakul, Theresa W. Guilbert, Michael D. Cabana, Kristie Ross, Joshua Blatter, Edna Acosta-Pérez, Gregory E. Miller, Rafael E. de la Hoz, Franziska J. Rosser, Sandy Durrani, Glorisa Canino, Stephen R. Wisniewski, Juan C. Celedón Eur Respir J, 59 (5) 2102329; 10.1183/13993003.02329-2021
Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease Charlotte Rigauts, Juliana Aizawa, Steven L. Taylor, Geraint B. Rogers, Matthias Govaerts, Paul Cos, Lisa Ostyn, Sarah Sims, Eva Vandeplassche, Mozes Sze, Yves Dondelinger, Lars Vereecke, Heleen Van Acker, Jodie L. Simpson, Lucy Burr, Anne Willems, Michael M. Tunney, Cristina Cigana, Alessandra Bragonzi, Tom Coenye, Aurélie Crabbé Eur Respir J, 59 (5) 2101293; 10.1183/13993003.01293-2021
Heterogeneity of treatment response in bronchiectasis clinical trials Oriol Sibila, Elena Laserna, Amelia Shoemark, Lidia Perea, Diana Bilton, Megan L. Crichton, Anthony De Soyza, Wim G. Boersma, Josje Altenburg, James D. Chalmers Eur Respir J, 59 (5) 2100777; 10.1183/13993003.00777-2021
Long-term outcomes of adult pulmonary Langerhans cell histiocytosis: a prospective cohort Amira Benattia, Emmanuelle Bugnet, Anouk Walter-Petrich, Constance de Margerie-Mellon, Véronique Meignin, Agathe Seguin-Givelet, Gwenaël Lorillon, Sylvie Chevret, Abdellatif Tazi Eur Respir J, 59 (5) 2101017; 10.1183/13993003.01017-2021
Scan-based competing death risk model for re-evaluating lung cancer computed tomography screening eligibility Anton Schreuder, Colin Jacobs, Nikolas Lessmann, Mireille J.M. Broeders, Mario Silva, Ivana Išgum, Pim A. de Jong, Michel M. van den Heuvel, Nicola Sverzellati, Mathias Prokop, Ugo Pastorino, Cornelia M. Schaefer-Prokop, Bram van Ginneken Eur Respir J, 59 (5) 2101613; 10.1183/13993003.01613-2021
Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-ß receptor I Jiancheng Wang, Xiaofan Lai, Senyu Yao, Hainan Chen, Jianye Cai, Yulong Luo, Yi Wang, Yuan Qiu, Yinong Huang, Xiaoyue Wei, Boyan Wang, Qiying Lu, Yuanjun Guan, Tao Wang, Shiyue Li, Andy Peng Xiang Eur Respir J, 59 (5) 2003721; 10.1183/13993003.03721-2020
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis Shengren Song, Zhenli Fu, Ruijuan Guan, Jie Zhao, Penghui Yang, Yang Li, Hang Yin, Yunxin Lai, Gencheng Gong, Simin Zhao, Jiangtian Yu, Xiaomin Peng, Ying He, Yumei Luo, Nanshan Zhong, Jin Su Eur Respir J, 59 (5) 2100864; 10.1183/13993003.00864-2021
The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD Feng Xu, Dragos M. Vasilescu, Daisuke Kinose, Naoya Tanabe, Kevin W. Ng, Harvey O. Coxson, Joel D. Cooper, Tillie-Louise Hackett, Stijn E. Verleden, Bart M. Vanaudenaerde, Christopher S. Stevenson, Marc E. Lenburg, Avrum Spira, Wan C. Tan, Don D. Sin, Raymond T. Ng, James C. Hogg Eur Respir J, 59 (5) 2101411; 10.1183/13993003.01411-2021
Guide sheath versus non-guide sheath method for endobronchial ultrasound-guided biopsy of peripheral pulmonary lesions: a multicentre randomised trial Masahide Oki, Hideo Saka, Tatsuya Imabayashi, Daisuke Himeji, Yoichi Nishii, Harunori Nakashima, Daisuke Minami, Shotaro Okachi, Yasuyuki Mizumori, Masahiko Ando Eur Respir J, 59 (5) 2101678; 10.1183/13993003.01678-2021
Cardiac sarcoidosis: systematic review of the literature on corticosteroid and immunosuppressive therapies Julien Stievenart, Guillaume Le Guenno, Marc Ruivard, Virginie Rieu, Marc André, Vincent Grobost Eur Respir J, 59 (5) 2100449; 10.1183/13993003.00449-2021
Sleep apnoea and heart failure Patrick Lévy, Matthew T. Naughton, Renaud Tamisier, Martin R. Cowie, T. Douglas Bradley Eur Respir J, 59 (5) 2101640; 10.1183/13993003.01640-2021
Extended D-dimer cut-offs and machine learning for ruling out pulmonary embolism in individuals undergoing computed tomography pulmonary angiography Alessandro N. Franciosi, Nicholas McCarthy, Brian Gaffney, John Duignan, Eamon Sweeney, Niall O'Connell, Karen Murphy, Fionnuala Ní Áinle, Marcus W. Butler, Jonathan D. Dodd, Michael P. Keane, David J. Murphy, Kathleen M. Curran, Cormac McCarthy Eur Respir J, 59 (5) 2200075; 10.1183/13993003.00075-2022
Sputum cell counts in COPD patients who use electronic cigarettes Andrew Higham, Augusta Beech, Natalie Jackson, Simon Lea, Dave Singh Eur Respir J, 59 (5) 2103016; 10.1183/13993003.03016-2021
Extracorporeal life support allows lung transplant in anti-MDA5+ rapidly progressive interstitial lung disease Pierre Bay, Marc Pineton de Chambrun, Antoine Roux, Vincent Bunel, Alain Combes, Dominique Israël-Biet, Benjamin Zuber, Hilario Nunes, Yves Allenbach, Yurdagül Uzunhan Eur Respir J, 59 (5) 2102968; 10.1183/13993003.02968-2021
The identification of prevalent tuberculosis disease through infection screening among high-risk migrants in the Netherlands Ineke Spruijt, Chantal Joren, Henrieke Schimmel, Frouke Procee, Yalda Alam, Susan van den Hof, Connie Erkens Eur Respir J, 59 (5) 2103018; 10.1183/13993003.03018-2021
Inhaled corticosteroids for outpatients with COVID-19: a meta-analysis Todd C. Lee, Émilie Bortolussi-Courval, Sara Belga, Nick Daneman, Adrienne K. Chan, Ryan Hanula, Nicole Ezer, Emily G. McDonald Eur Respir J, 59 (5) 2102921; 10.1183/13993003.02921-2021
Aspergillus tracheobronchitis in COVID-19 patients with acute respiratory distress syndrome: a cohort study Philipp Koehler, Saskia von Stillfried, Jorge Garcia Borrega, Frieder Fuchs, Jon Salmanton-García, Fabian Pult, Boris Böll, Dennis A. Eichenauer, Alexander Shimabukuro-Vornhagen, Oliver Kurzai, Peter Boor, Matthias Kochanek, Oliver A. Cornely Eur Respir J, 59 (5) 2103142; 10.1183/13993003.03142-2021
Prednisolone plus itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma: is the benefit worth the risk? Alice Havette, Lucile Regard, Nicolas Roche, Pierre-Régis Burgel Eur Respir J, 59 (5) 2102924; 10.1183/13993003.02924-2021
Reply: Prednisolone plus itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma: is the benefit worth the risk? Ritesh Agarwal, Valliappan Muthu Eur Respir J, 59 (5) 2102989; 10.1183/13993003.02989-2021
Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport? Marissa O'Callaghan, Feargal Helly, Elizabeth Tarling, Michael P. Keane, Cormac McCarthy Eur Respir J, 59 (5) 2102594; 10.1183/13993003.02594-2021
Reply: Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport? Alice Hadchouel, Christophe Delacourt Eur Respir J, 59 (5) 2102937; 10.1183/13993003.02937-2021