April

Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment Eur Respir J, 59 (4) 2200166; 10.1183/13993003.00166-2022
CPAnet: the challenges of gaining evidence-based knowledge in chronic pulmonary aspergillosis Rosanne Sprute, Helmut J.F. Salzer, Danila Seidel Eur Respir J, 59 (4) 2102879; 10.1183/13993003.02879-2021
Targeted therapy for pulmonary alveolar proteinosis: the time is now Francesco Bonella, Raphael Borie Eur Respir J, 59 (4) 2102971; 10.1183/13993003.02971-2021
Proteinases in the pathogenesis of lymphangioleiomyomatosis lung disease: nibbling or chewing up the lung? Yael Aschner, Gregory P. Downey Eur Respir J, 59 (4) 2200405; 10.1183/13993003.00405-2022
The paradox of immunosuppressants and COVID-19 Guang-Shing Cheng, Scott E. Evans Eur Respir J, 59 (4) 2102828; 10.1183/13993003.02828-2021
Can CPAP protect from cancer incidence in obstructive sleep apnoea patients? No evidence yet Francesco Gambino, Maria R. Bonsignore Eur Respir J, 59 (4) 2102742; 10.1183/13993003.02742-2021
The last-minute redemption of inflammatory cells in lung repair Paula Martín-Vicente, Cecilia López-Martínez, Guillermo M. Albaiceta Eur Respir J, 59 (4) 2103000; 10.1183/13993003.03000-2021
Some forgotten issues in sleep apnoea Miguel Ángel Martínez-García, Patrick Lévy Eur Respir J, 59 (4) 2101627; 10.1183/13993003.01627-2021
ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure Simon Oczkowski, Begüm Ergan, Lieuwe Bos, Michelle Chatwin, Miguel Ferrer, Cesare Gregoretti, Leo Heunks, Jean-Pierre Frat, Federico Longhini, Stefano Nava, Paolo Navalesi, Aylin Ozsancak Ugurlu, Lara Pisani, Teresa Renda, Arnaud W. Thille, João Carlos Winck, Wolfram Windisch, Thomy Tonia, Jeanette Boyd, Giovanni Sotgiu, Raffaele Scala Eur Respir J, 59 (4) 2101574; 10.1183/13993003.01574-2021
Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma John Busby, John G. Matthews, Rekha Chaudhuri, Ian D. Pavord, Timothy C. Hardman, Joseph R. Arron, Peter Bradding, Christopher E. Brightling, David F. Choy, Douglas C. Cowan, Ratko Djukanovic, Catherine E. Hanratty, Tim W. Harrison, Cecile T. Holweg, Peter H. Howarth, Stephen J. Fowler, James L. Lordan, Adel H. Mansur, Andrew Menzies-Gow, Robert M. Niven, Douglas S. Robinson, Samantha M. Walker, Ashley Woodcock, Liam G. Heaney Eur Respir J, 59 (4) 2100768; 10.1183/13993003.00768-2021
A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma Ritesh Agarwal, Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Mandeep Garg, Ashutosh Nath Aggarwal, Arunaloke Chakrabarti Eur Respir J, 59 (4) 2101787; 10.1183/13993003.01787-2021
Ex vivo delivery of regulatory T-cells for control of alloimmune priming in the donor lung Ei Miyamoto, Akihiro Takahagi, Akihiro Ohsumi, Tereza Martinu, David Hwang, Kristen M. Boonstra, Betty Joe, Juan Mauricio Umana, Ke F. Bei, Daniel Vosoughi, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Stephen C. Juvet Eur Respir J, 59 (4) 2100798; 10.1183/13993003.00798-2021
A systematic review of blood biomarkers with individual participant data meta-analysis of matrix metalloproteinase-7 in idiopathic pulmonary fibrosis Fasihul A. Khan, Iain Stewart, Gauri Saini, Karen A. Robinson, R. Gisli Jenkins Eur Respir J, 59 (4) 2101612; 10.1183/13993003.01612-2021
Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis Alice Hadchouel, David Drummond, Clément Pontoizeau, Laura Aoust, Maria-Margarita Hurtado Nedelec, Jamel El Benna, Elsa Gachelin, Caroline Perisson, Clémentine Vigier, Manuel Schiff, Florence Lacaille, Thierry Jo Molina, Laureline Berteloot, Sylvain Renolleau, Chris Ottolenghi, Jean-Marc Tréluyer, Jacques de Blic, Christophe Delacourt Eur Respir J, 59 (4) 2101554; 10.1183/13993003.01554-2021
Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis Jesse D. Kirkpatrick, Ava P. Soleimany, Jaideep S. Dudani, Heng-Jia Liu, Hilaire C. Lam, Carmen Priolo, Elizabeth P. Henske, Sangeeta N. Bhatia Eur Respir J, 59 (4) 2100664; 10.1183/13993003.00664-2021
Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study Akshay N. Gupte, Pavan Kumar, Mariana Araújo-Pereira, Vandana Kulkarni, Mandar Paradkar, Neeta Pradhan, Pradeep Menon, Chandrasekaran Padmapriyadarsini, Luke-Elizabeth Hanna, Shri Vijay Bala Yogendra Shivakumar, Neesha Rockwood, Elsa Du Bruyn, Rajesh Karyakarte, Sanjay Gaikwad, Robert Bollinger, Jonathan Golub, Nikhil Gupte, Vijay Viswanathan, Robert J. Wilkinson, Vidya Mave, Subash Babu, Hardy Kornfeld, Bruno B. Andrade, Amita Gupta Eur Respir J, 59 (4) 2100905; 10.1183/13993003.00905-2021
The effect of immunosuppressants on the prognosis of SARS-CoV-2 infection Daniel Ward, Sanne Gørtz, Martin Thomson Ernst, Nynne Nyboe Andersen, Susanne K. Kjær, Jesper Hallas, Steffen Christensen, Christian Fynbo Christiansen, Simone Bastrup Israelsen, Thomas Benfield, Anton Pottegård, Tine Jess Eur Respir J, 59 (4) 2100769; 10.1183/13993003.00769-2021
Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevão, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger Eur Respir J, 59 (4) 2100129; 10.1183/13993003.00129-2021
Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study Adrian Ceccato, Cristina Dominedò, Miquel Ferrer, Ignacio Martin-Loeches, Enric Barbeta, Albert Gabarrús, Catia Cillóniz, Otavio T. Ranzani, Gennaro De Pascale, Stefano Nogas, Pierluigi Di Giannatale, Massimo Antonelli, Antoni Torres Eur Respir J, 59 (4) 2100620; 10.1183/13993003.00620-2021
Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis Alexandre Tran, Shannon M. Fernando, Laurent J. Brochard, Eddy Fan, Kenji Inaba, Niall D. Ferguson, Carolyn S. Calfee, Karen E.A. Burns, Daniel Brodie, Victoria A. McCredie, Dennis Y. Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S. Slutsky, Alain Combes, Bram Rochwerg Eur Respir J, 59 (4) 2100857; 10.1183/13993003.00857-2021
The novel bronchodilator navafenterol: a phase 2a, multicentre, randomised, double-blind, placebo-controlled crossover trial in COPD Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wählby Hamrén, Wenjing Xin, Ioannis Psallidas Eur Respir J, 59 (4) 2100972; 10.1183/13993003.00972-2021
Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy Grégoire Justeau, Sebastien Bailly, Chloé Gervès-Pinquié, Wojciech Trzepizur, Nicole Meslier, François Goupil, Thierry Pigeanne, Sandrine Launois, Laurene Leclair-Visonneau, Philippe Masson, Acya Bizieux-Thaminy, Jean-Louis Racineux, David Gozal, Frédéric Gagnadoux Eur Respir J, 59 (4) 2101935; 10.1183/13993003.01935-2021
Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18?000 children Sara M. Mensink-Bout, Evelien R. van Meel, Johan C. de Jongste, Isabella Annesi-Maesano, Adrien M. Aubert, Jonathan Y. Bernard, Ling-Wei Chen, Cyrus Cooper, Sarah R. Crozier, Wojciech Hanke, Nicholas C. Harvey, James R. Hébert, Barbara Heude, Joanna Jerzynska, Cecily C. Kelleher, John Mehegan, Fionnuala M. McAuliffe, Catherine M. Phillips, Kinga Polanska, Caroline L. Relton, Nitin Shivappa, Matthew Suderman, Vincent W.V. Jaddoe, Liesbeth Duijts Eur Respir J, 59 (4) 2101315; 10.1183/13993003.01315-2021
The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function Wioletta Skronska-Wasek, Sibel Durlanik, Huy Quang Le, Victoria Schroeder, Kerstin Kitt, James Peter Garnett, Stefan Pflanz Eur Respir J, 59 (4) 2002732; 10.1183/13993003.02732-2020
VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury Masahiro Yamashita, Miyuki Niisato, Yasushi Kawasaki, Sinem Karaman, Marius R. Robciuc, Yuji Shibata, Yoji Ishida, Ryosuke Nishio, Tomoyuki Masuda, Tamotsu Sugai, Masao Ono, Rubin M. Tuder, Kari Alitalo, Kohei Yamauchi Eur Respir J, 59 (4) 2100880; 10.1183/13993003.00880-2021
Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice Marija Gredic, Cheng-Yu Wu, Stefan Hadzic, Oleg Pak, Rajkumar Savai, Baktybek Kojonazarov, Siddartha Doswada, Astrid Weiss, Andreas Weigert, Andreas Guenther, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Simone Kraut, Norbert Weissmann Eur Respir J, 59 (4) 2101153; 10.1183/13993003.01153-2021
Sleep apnoea in the elderly: a great challenge for the future Ricardo S. Osorio, Miguel Ángel Martínez-García, David M. Rapoport Eur Respir J, 59 (4) 2101649; 10.1183/13993003.01649-2021
Spirometry forced expiratory time is driven by airflow limitation in asthmatic children Jessica Taytard, Marc Koskas, Nicole Beydon Eur Respir J, 59 (4) 2102620; 10.1183/13993003.02620-2021
Epigenetic age acceleration in obstructive sleep apnoea is reversible with adherent treatment Rene Cortese, David Sanz-Rubio, Leila Kheirandish-Gozal, José Maria Marin, David Gozal Eur Respir J, 59 (4) 2103042; 10.1183/13993003.03042-2021
Temporal progression of mediastinal lymphadenopathy in idiopathic pulmonary fibrosis Tim J.M. Wallis, Eyjólfur Gudmundsson, Katarina Pontoppidan, Nesrin Mogulkoc, Recep Savas, Ömer Selim Unat, Katharine Vedwan, Sobana Battison, Fiona J. Thompson, Christopher J. Brereton, Ben G. Marshall, Sophie V. Fletcher, Luca Richeldi, Joseph Jacob, Mark G. Jones Eur Respir J, 59 (4) 2200024; 10.1183/13993003.00024-2022
Practices of therapeutic drug monitoring in tuberculosis: an international survey Ioana Margineanu, Onno Akkerman, Dario Cattaneo, Delia Goletti, Deborah J.E. Marriott, Giovanni Battista Migliori, Fuad Mirzayev, Charles A. Peloquin, Ymkje Stienstra, Jan-Willem Alffenaar Eur Respir J, 59 (4) 2102787; 10.1183/13993003.02787-2021
Addition of bacterial filter alters positive airway pressure and non-invasive ventilation performances Claudio Rabec, Emeline Fresnel, Yann Rétory, Kaixian Zhu, Karima Joly, Adrien Kerfourn, Benjamin Dudoignon, Alexis Mendoza, Antoine Cuvelier, Jean-François Muir, Boris Melloni, Jean-François Chabot, Jésus Gonzalez-Bermejo, Maxime Patout Eur Respir J, 59 (4) 2102636; 10.1183/13993003.02636-2021
The optimal arterial oxygenation range in critical care Lingzhong Meng, Xu Zhao, Eddy Fan Eur Respir J, 59 (4) 2102596; 10.1183/13993003.02596-2021
Pulse oximeter measurements vary across ethnic groups: an observational study in patients with COVID-19 Colin J. Crooks, Joe West, Joanne R. Morling, Mark Simmonds, Irene Juurlink, Steve Briggs, Simon Cruickshank, Susan Hammond-Pears, Dominick Shaw, Timothy R. Card, Andrew W. Fogarty Eur Respir J, 59 (4) 2103246; 10.1183/13993003.03246-2021
War in Ukraine: an immense threat to the fight against tuberculosis Victor Dahl, Giovanni Battista Migliori, Christoph Lange, Christian Wejse Eur Respir J, 59 (4) 2200493; 10.1183/13993003.00493-2022
Correlation of total serum HDL particles with a predictor of mortality risk in idiopathic pulmonary fibrosis Taro Yasuma, Corina N. D'Alessandro-Gabazza, Hajime Fujimoto, Tetsu Kobayashi, Esteban C. Gabazza Eur Respir J, 59 (4) 2103175; 10.1183/13993003.03175-2021
Reply: Not all HDL particles are equal in idiopathic pulmonary fibrosis Amisha V. Barochia, Scott D. Barnett, Nargues Weir, Stewart J. Levine, Steven D. Nathan Eur Respir J, 59 (4) 2200151; 10.1183/13993003.00151-2022
Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity Sophie M. Poznanski, Ana Portillo, Manali Mukherjee, Anurag Bhalla, Kiho Son, Ali A. Ashkar, Nader Khalidi, Parameswaran Nair Eur Respir J, 59 (4) 2102210; 10.1183/13993003.02210-2021
“Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension.” Catherine E. Simpson, Jenny Y. Chen, Rachel L. Damico, et al. Eur Respir J 2020; 55: 1901761. Eur Respir J, 59 (4) 1951761; 10.1183/13993003.51761-2019
“Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.” Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, et al. Eur Respir J 2021; 57: 2002559. Eur Respir J, 59 (4) 2052559; 10.1183/13993003.52559-2020