Mucosal immunology of the lung: balancing protective immunity and chronic inflammation, Estoril 2022

The Lung Science Conference is at the forefront of basic and translational respiratory science and it is an essential event for budding respiratory researchers looking to boost their career.

Educational aims

To present the very best of international lung science research
To highlight new discoveries likely to impact on the future of respiratory medicine
To encourage debate and interaction between young postdoctoral scientists and established investigators

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Welcome and Introduction Reinoud Gosens (Netherlands)
Opening Lecture: Cytokines: Orchestrating immune responses in lung disease Anne O’Garra (United Kingdom)
Healthy atlas of the human airways Laure Emmanuel Zaragosi (France)
Integrated human lung cell atlas & Launch of the human cell atlas platform Malte Lücken (Germany)
OP01 – The multi-omics spatial lung atlas reveales new cell states and their functions in airway mesenchyme Elo Madissoon (United Kingdom)
Local and systemic response to SARS-CoV-2 infection in children and adults Kerstin Meyer (United Kingdom)
Role of macrophages plasticity in chronic and infectious lung disease Scott Budinger (USA)
OP02 – Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma Franziska Hartung (Germany)
Innate and adaptive immune responses to RV René Lutter (Netherlands)
OP03 – G-CSF drives pathophysiology of RV-induced allergic asthma exacerbations by potentiating neutrophilic inflammation and ILC2 function Nicoletta Bruno (United Kingdom)
OP04 – Identification of a host antiviral and anti-inflammatory metabolite that protects against influenza virus-driven morbidity and mortality Mustapha Si-Tahar (France)
Tissue resident T cells in healthy and diseased lung Donna Farber (USA)
OP05 – A high probability of short-range interactions between fibrocytes and CD8+ T cells potentiates the inflammatory response in COPD Edmée Eyraud (France)
OP06 – Gene signature for patient stratification: Lessons learned from IL-33 stimulated TH2 genes Akshaya Keerthi Saikumar Jayalatha (Netherlands)
Inducible bronchus associated lymphoid tissue drives immunity in COPD Ali Önder Yildirim (Germany)
OP07 – Inflammatory blood neutrophils in COPD stem from activated bone marrow progenitors Theodore Kapellos (Germany)
Trained immunity and allergy: State of the art and future perspectives Uta Jappe (Germany)
OP08 – COPD Monocyte-derived macrophages display hallmarks of senescence Shyreen Hassibi (United Kingdom)
YI01 – Human CD116+ fetal liver progenitors migrate to the perinatal lung and give rise to alveolar macrophages in vivo Elza Evren (Sweden)
YI02 – The potential role of innate lymphoid cells in non-allergic neutrophilic asthma model Anne-Charlotte Jonckheere (Belgium)
YI03 – A novel IgA plasma cell niche in the human airways Amanda Oliver (United Kingdom)
YI04 – d Influenza infection of epithelial cells alters extracellular vesicle microRNA involved in viral replication and the immune response Laura Reid (United Kingdom)
YI05 – Resolving aging-related cellular phenotypes in pulmonary fibrosis by longitudinal single-cell transcriptomics Janine Schniering (Germany)
Tools for career development – Introduction Niki Ubags (Switzerland)
Effective teaching and mentoring: where to start? Agnes Boots (Netherlands)
How to collaborate successfully (industry vs academic perspective) – part 1 Alexander Mackay (Sweden)
How to collaborate successfully (industry vs academic perspective) – part 2 Rachel Chambers (United Kingdom)
Transferable skills: you are more than ‘just’ a scientist! Verity Elston (Switzerland)
Setting the scientific playfield outside academia: a career in scientific editing Timothy Powell (United Kingdom)
Panel discussion and networking event
Virus provided protection against allergic asthma Laurent Gillet (Belgium)
The cellular landscape of the airways in asthma Martijn Nawijn (Netherlands)
Cytokines targeted therapies in asthma versus COPD Guy Brusselle (Belgium)
Precision medicine: New biomarkers and targets beyond T2 inflammation Chris Brightling (United Kingdom)
Role of lung microbiome in airway diseases James Chalmers (United Kingdom)
Conclusion by Reinoud Gosens, ERS Conferences and Seminars Director
Mentoring session: Exchanging & sharing tips on career plans / preparing the next career phase Aideen Caitriona Allen & Diana Van Der Plaat
Mentoring session: Reviewing training (how to be a good reviewer for grants/Papers etc) Olivier Burgy, Imran Satia, Thomas Gille & Karen Moor
Mentoring session: Tips on grant applications & management, including budget development and monitoring Eva Garrido, Imran Satia & Niki Ubags
Mentoring session: Preparing an outstanding oral presentation / how to prepare for an interview Cristina Longo, Pauline Bardin, Holly Keir & Thomas Gille
Mentoring session: How to collaborate successfully on an international level (including more practical aspects such as material transfer agreements) Dimosthenis Lykouras, Sara Rolandsson Enes & Niki Ubags
TP101 - Longitudinal impact of conjugated pneumococcal vaccine (PCV13) on cytokine profile in different asthma phenotypes Kostinov Anton, Russian Fed.
TP102 - A helminth glutamate dehydrogenase targets eicosanoid pathways to modulate type-2 immunity Sina Bohnacker, Germany
TP103 - Characterization of neutrophilic responses in a pollutant-aggravated asthma mouse model Joyceline De Volder, Belgium
TP104 - Post-COVID: The multimodal path to the right treatment strategy Daniel Gagiannis, Germany
TP105 - Pulmonary In Vitro Perfusion (PIPE) Model to Study Cellular Crosstalk in Neonatal Pulmonary Vascular Disease Motaharehsadat Heydarian, Germany
TP106 - Distinct metabolic reprogramming of airway epithelium in asthma in response to infection with rhinovirus Mengting Huang, Switzerland
TP107 - Innate immunity plays an important role during NTHI and RV sequential infection. Yuqing Long, United Kingdom
TP108 - Antibiotic-induced microbial disruption drives metabolic rewiring in pulmonary macrophages and a dysregulated type 2 response in the lung Elizabeth Mann, United Kingdom
TP109 - Monocyte migratory signatures identify acute and convalescent COVID-19 patients, and are associated with long COVID-19 symptoms Laurence Pearmain, United Kingdom
TP110 - Phenotype and severity of asthma determines bronchial epithelial immune responses to a viral mimic Celeste Michala Porsbjerg, Denmark
TP111 - Polymeric immunoglobulin receptor and immunoglobulin A system in an eosinophilic mouse model of chronic rhinosinusitis Alba Sánchez Montalvo, Belgium
TP113 - Specialized pro-resolving mediators’ biosynthesis by cystic fibrosis airway epithelial cells and their impact on mucociliary clearance Maelle Briottet, France
TP114 - Spatial ECM proteomics resolves instructive tissue niches in the distal human lung Yuexin Chen, Germany
TP115 - Insulin-like Growth Factor 1 Receptor facilitates NSCLC tumor growth acting in the tumor microenvironment José Manuel García Pichel, Spain
TP116 - Lineage tracing of cells expressing the mesenchymal profibrotic transcription factor Prrx1 in the normal and fibrotic lung Méline Homps-Legrand, France
TP118 - Exploring IL13 effects on the remodeling of airway epithelial cell populations by single-cell RNA sequencing Elisa Redman, France
TP119 - The chitinase-like protein Ym2 is an amplifier of innate type 2 responses Ursula Smole, Belgium
TP120 - Local airway expression of lnc-SERPINA12-1 in children with Cystic Fibrosis Zuzanna Stachowiak, Poland
TP121 - High-dimensional characterisation of the airway wall of paediatric patients with asthma and pre-school wheeze using Imaging Mass Cytometry William Traves, United Kingdom
TP122 - Exploring the role of infection experienced lung stromal cells following re-challenge with influenza A virus Julie Worrell, United Kingdom
TP123 - Lung Cancer-Associated Fibroblasts in MHCII immunity: Understanding its Molecular Basis to Design Novel Immunotherapies Ilias Angelidis, Greece
TP125 - Mapping the Immune Response Diversity after Murine Lung Transplantation Janne Kaes, Belgium
TP126 - Differential expression of PD-1/PD-L1 axis in mediastinal lymph nodes of experimental and human lung fibrosis Theodoros Karampitsakos, Greece
TP127 - Mitochondrial iron regulates AEC2 dysfunction, senescence and senescent associated secretory phenotype in response to bleomycin challenge Sarah Kenny, Ireland
TP128 - Broncho-vascular mesenchymal stromal cells guided spatiotemporal establishment of antibody secreting cell pro-survival niches in the lung Vibha N. Lama, USA
TP129 - Pulmonary macrophage subsets associated with lung allograft dysfunction revealed by single-cell RNA sequencing Sajad Moshkelgosha, Canada
TP130 - Hyaluronan (HA) accumulation following SARS-CoV-2 infection and in non-resolvable COVID-19 fibrosis Andrew Peters, USA
TP131 - Biosynthesis and implementation of Thyroid Receptor beta (TRß) agonists (thyromimetics) for the treatment of pulmonary fibrosis Argyris Tzouvelekis, Greece
TP132 - Myeloid cells immunomodulate tissue niches and promotes idiopathic pulmonary fibrosis Valeria Viteri-Alvarez, Germany
TP134 - Circular RNA expression in cystic fibrosis bronchial epithelium Chiara De Santi, Ireland
TP135 - Extracellular vesicles produced by airway epithelial cells from COPD patients contain miRNAs involved in cellular senescence Justine Devulder, United Kingdom
TP136 - Effects of blocking TSLP on ILC and T cell subpopulations in patients with asthma Nanna Dyhre-Petersen, Denmark
TP137 - Construction of a 3D innervated bronchial epithelium from human induced pluripotent stem cells iPSC Florent Foisset, France
TP138 - Alveolar macrophages from people with severe eosinophilic asthma show differential antiviral responses to human rhinovirus 16 and SARS-CoV-2. Andrew Hearn, United Kingdom
TP139 - Regulation of MHC I expression in lung epithelial cells during inflammation Justine Mathé, Canada
TP140 - Effect of eosinophilopoetins on proliferative properties of blood eosinophil subtypes in allergic asthma Jolita Palacionyte, Lithuania
TP141 - Kynurenine pathway as a modulator of inflammation in COPD and its exacerbations Odile Poulain Odefroy, France
TP143 - Inhibiting RIPK1 kinase activity is protective in experimental models of COPD Hannelore P. Van Eeckhoutte, Belgium
TP144 - Cigarette smoke modulates cellular responses of differentiated human bronchial epithelial cells to rhinovirus-A16 infection Ying Wang, Netherlands
TP202 - Targeting CXCR4 as a therapeutic strategy to improve outcomes in a mouse model of early chronic obstructive pulmonary disease (COPD) Isabelle Dupin, France
TP203 - Reactivation of latent virus infection links air pollutants to chronic lung disease Verena Haefner, Germany
TP204 - No differences in cytokine responses to moderate-intensity exercise in -10°C versus 10°C. Helen Hanstock, Sweden
TP205 - Different Effects of Inhaled Corticosteroids on Infiltrating Mast Cells in Type 2 High and Type 2 Low Asthma Morten Hvidtfeldt, Denmark
TP206 - Real time in vivo investigation of the innate immune response during ventilator-assisted nanoparticle inhalation Qiongliang Liu, Germany
TP207 - Elevated ferritin is associated with systemic inflammation, inflammasome activation and mortality in Acute Respiratory Distress Syndrome (ARDS) Puja Mehta, United Kingdom
TP208 - Effects of probiotics in uncontrolled asthma Catherine Moermans, Belgium
TP209 - Budesonide reduces the bronchial epithelial response to a viral mimic in T2high asthma, and boosts anti-microbial responses in T2low asthma Juan-José Nieto-Fontarigo, Sweden
TP210 - Differential toxicity in an alveolar epithelial cell line of fine particulate matter from brakewear, roadwear, and diesel exhaust James Parkin, United Kingdom
TP211 - Inhaled continuous exposure to farmyard microbes suppress type 2 inflammation in a neonatal murine model of viral-induced wheeze and asthma Kunyuan Tian, United Kingdom
TP212 - Allergen exposure induces airway macrophage metabolic reprogramming Gesa J Albers, United Kingdom
TP213 - Mast cell tryptase contribute to airway remodelling by inducing pro-survival and cell growth properties in lung epithelial cells Frida Berlin, Sweden
TP214 - The memory of airway epithelium damage in smokers and COPD patients François Carlier, Belgium
TP215 - Human lung microbiota drives differential innate immune response Sudip Das, Switzerland
TP216 - Expression of miR-185-5p, miR-146b-5p, miR-320b, miR-21-5p in Blood Eosinophil Subtypes and Plasma in Allergic Asthma Patients Egle Jurkeviciute, Lithuania
TP217 - The role of IGF2BP3 in Type 2 signalling in bronchial epithelium: a novel player in severe asthma Paniz Khooshemehri, United Kingdom
TP218 - IL-13 modulates exosome production and miRNAs cargo in bronchial epithelial cells in severe asthma Martin Klein, Canada
TP219 - Function-specific IL17A and Dexamethasone interactions in primary human airway epithelial cells Siti Farah Rahmawati, Netherlands
TP220 - Impact of treatments targeting the GM-CSF pathway on the functions of human pulmonary macrophages Hélène Salvator, France
TP221 - Generation of apical-out airway organoids from human primary airway epithelial cells Georgios Stroulios, United Kingdom
TP223 - NTHi-IAV coinfection of macrophages alters infection outcomes and inflammatory responses Karl Staples, United Kingdom
TP224 - Pseudomonas aeruginosa modulates mucosal immune response to rhinovirus infection in an in-vitro chronic infection model Adrian Endres, Germany
TP225 - Chronic Bacterial Airways Infection in Severe Asthma Maisha Jabeen, United Kingdom
TP226 - The Cathelicidin LL-37 and microbial dysbiosis in COPD patients receiving inhaled corticosteroids Holly Rachael Keir, United Kingdom
TP227 - Ex vivo modelling of human lung fibrogenesis and drug mode of action screens using single-cell RNA-seq in precision-cut lung slices Niklas Lang, Germany
TP228 - G-protein coupled receptor 87 is a novel basal cell marker in distal IPF bronchioles Mareike Lehmann, Germany
TP229 - Profiling systemic inflammation and neutrophil function in hospitalized patients with COVID19: results from PREDICT-COVID19 Merete Long, United Kingdom
TP230 - The microbiota plays a critical role in the reactivity of lung immune components to innate ligands Quentin Marquant, France
TP231 - Modulation of antiviral responses to rhinovirus by the nonsense mediated decay pathway and implications in rhinovirus-induced exacerbations Rocio Teresa Martinez-Nunez, United Kingdom
TP232 - Extracellular vesicles and soluble factors secreted by lung fibroblasts support alveolar organoid formation Luke Van Der Koog, Netherlands
TP233 - Single cell transcriptomic dissection of virus induced immunopathology in interferon gamma receptor null mice Lin Yang, Germany
TP235 - Lung surfactant lipids reduce the alternative activation and proliferation of alveolar macrophages induced by IL-4 Cristina Casals, Spain
TP236 - Monocyte migration and COPD pathogenesis are epigenetically regulated by PRMT7 Aicha Jeridi, Germany
TP238 - Biomarker identification to assess effects of bone-marrow derived mesenchymal stromal cell-therapy in emphysema through immune profiling Padmini P. S. J. Khedoe, Netherlands
TP239 - An ex vivo model of cellular senescence and inflammaging in precision-cut lung slices Maria Camila Melo Narvaez, Germany
TP240 - Support of human alveolar organoid growth by pulmonary endothelial cells: possible influence of cigarette smoke exposure Abilash Ravi, Netherlands
TP241 - Overzealous degradation of collagen fragment Pro-Gly-Pro by leukotriene A4 hydrolase (LTA4H) perpetuates fibrosis in IPF Kornelija Suveizdyte, United Kingdom
TP242 - Mitochondrial DNA stress in lung parenchymal cells activates autoreactive CD8+ T cells - implications for pulmonary fibrosis Silke Meiners, Germany
TP244 - Cigarette smoke and air pollution induce dysfunctional pulmonary microvascular endothelial repair Xinhui Wu, Netherlands
eP303 - The level of sIgA in nasal secretions and the incidence of complications in hospitalized patients with COVID-19 against an immunotropic drug N. D. Abramova, Russian Fed.
eP304 - CT scan imaging in acute infectious infiltrative lung disease before the covid-19 era Meriem Affes, Tunisia
eP306 - The biological activity of interferons in post-COVID syndrome Lidia Arifullina, Russian Fed.
eP307 - Mitochondrial alterations in T cells after invivo and invitro smoke exposure Vidya Srokshna Balasubramanian Lakshmi, Germany
eP308 - Serum Levels of Surfactant Protein-B (SP-B) as biomarker in IPF and ILD-SSc Gabriele Bartoli, Italy
eP309 - Single-cell analysis reveals airway epithelial cell-specific expression quantitative trait loci in asthma Marijn Berg, Netherlands
eP310 - NK and T cell in patients with end-stage lung disorders waiting for lung transplantation in response to CMV infection. Laura Bergantini, Italy
eP311 - Protective effect of interferon type I on barrier function of human airway epithelium during rhinovirus infections in vitro Helena Boland, Germany
eP312 - Receptor-binding domain of SARS-CoV-2 facilitates internalization of 100 nm particles by neutrophils in conducting airway mucosa of mice. Elena Bolkhovitina, Russian Fed.
eP315 - Eosinophilic exacerbations of chronic obstructive pulmonary disease (COPD) have elevated reactive oxygen species (ROS) release James Camp, United Kingdom
eP316 - The metabolite succinate inhibits influenza virus replication through succinylation and nuclear retention of the viral nucleoprotein Adeline Cezard, France
eP317 - The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface Maitrayee Chatterjee, Netherlands
eP318 - Ionic Calcium in Blood as Early Marker of Severity in Patients with COVID-19 Jorge Nelson Chung Ching, Peru
eP320 - Novel nasal virosome spray vaccine to protect against COVID-19 Tiziana Patrizia Cremona, Switzerland
eP321 - Impact of cigarette smoke on caspases activation and gasdermin D cleavage in human macrophages Marta Cristaldi, Italy
eP324 - Immune-Checkpoint expression on CD4, CD8 and NK cells in blood, BAL and lymph nodes of sarcoidosis Miriana D'Alessandro, Italy
eP325 - Source-related composition and toxicological effects of shipping-associated particulate matter Lareb Dean, United Kingdom
eP326 - Diesel exposure favors lung cancer progression through induction of an inflammatory microenvironment Marie-Laure Delhez, Belgium
eP327 - Correlations between volumetric capnography and automated computed tomography quantitative analysis in patients with severe COPD Odair Diniz, Brazil
eP328 - Cigarette smoke extract promotes caspase-1 activation and IL-18 release in primary human bronchial epithelial cells Paola Dino, Italy
eP329 - The impact of virus infection on the development of Bronchopulmonary Dysplasia (BPD) Anna Dmitrieva, Germany
eP331 - Chronic unpredictable stress exacerbates allergic airway inflammation in mice. Guilherme Dragunas, Netherlands
eP332 - Cigarette smoke alters macrophage mitochondrial iron handling in COPD Lynne Faherty, Ireland
eP333 - Physiomimetic culture of mesenchymal stromal cells affects macrophage activity in a paracrine manner. Bryan Falcones, Sweden
eP334 - Features of submicroscopic structure of respiratory part of lungs in early stages of development of streptozotocin-induced diabetes mellitus Yuliya Fedorchenko, Ukraine
eP335 - Bronchiectasis in severe asthma is associated with eosinophilic airway inflammation and activation Laurits Frøssing, Denmark
eP336 - Using lung organoids to recapitulate HRas/NRas-double knockout alveolar maturation defects in mice Rocío Fuentes-Mateos, Spain
eP337 - A study to evaluate nasal mucosal IgA development in neonates using a non-invasive sampling method Genevieve Po Gee Fung, Hong Kong
eP338 - Decreased expression of S100A7/A8/A9 in severe asthmatics following bronchial thermoplasty Pierre-Alexandre Gagnon, Canada
eP339 - Cooperation between fatty acid binding protein 5 and peroxisome proliferator-activated receptor gamma in regulating macrophage programming Fabienne Gally, USA
eP340 - Understanding the cellular immune response in silicosis by exposing human lymphocytes to silica nanoparticles Nirosha Ganesan, Belgium
eP341 - Synergistic action of apoptotic cells and surfactant protein A in boosting IL-4-dependent alternative activation of alveolar macrophages Belen Garcia-Fojeda, Spain
eP342 - Transcriptional response to RSV in asthma primary bronchial epithelial cells: are the basal cells responsible for the reduced NF-kB response? Aurore Gay, Netherlands
eP343 - Lung volume and density assessment over time in hospitalized COVID-19 patients Vincent Geudens, Belgium
eP344 - Involvement of FGF21 in pulmonary fibrosis Mada Ghanem, France
eP345 - Prenatal exposure to ozone triggers development of lung diseases in offspring Alison Gillard, Belgium
eP346 - Exploring the anti-inflammatory effect of commensal lung microbiota members in a 3-D lung epithelial cell model Ellen Goeteyn, Belgium
eP348 - Human mast cell differentiation optimization to study MRGPRX2-induced activation in vitro Janne Goossens, Belgium
eP349 - Human plasma-derived IgG protects against respiratory pathogens in an epithelial air-liquid interface model Stefanie Graeter, Switzerland
eP350 - Diesel exhaust particles and TNF-alpha or LPS induce pro-inflammatory pathways, including TSLP expression, in bronchial epithelial cells Fien Gysens, Belgium
eP351 - End stage lung disease is characterized by a pro-inflammatory imbalance in the innate lymphoid cell compartment. Olga Halle, Germany
eP352 - Environmental Nanoparticle Exposure Triggers Herpesvirus Reactivation via MAPK Signaling Pathway Lianyong Han, Germany
eP353 - Average Volume Assured Pressure Support Auto-titrating EPAP(AVAPS-AE) mode in Lung Cancer Patients with Respiratory Failure BoXue Han, China
eP354 - Nasal mucosal lining fluid (MLF) biomarkers for monitoring acute and chronic respiratory disease Sarah Harbach, United Kingdom
eP355 - The effect of interferon-alpha-2b therapy on humoral immunity after COVID-19 infection Albina Hasanova, Russian Fed.
eP356 - Systematic review and meta-analysis of interstitial lung disease transcriptomics Daniel He, Canada
eP357 - COVID-19 and smoking: Worse outcome from a surveillance analysis Gholamreza Heydari, Iran
eP358 - A novel non-invasive approach to quantify microRNA expression in nasal fluid from COPD patients using a microfluidic platform Vanessa Ho, United Kingdom
eP359 - Relations between blood and tissue microbiome in sarcoidosis patients Yordan Hodzhev, Bulgaria
eP360 - Novel alveolar macrophage-like model (ImmuPHAGE) as a platform for better mechanistic understanding for the fate of inhaled medicines. Ewelina Hoffman, United Kingdom
eP362 - Community-based asthma assessment in young children: Adaptations for a multicentre longitudinal study in South Asia Mohammad Shahidul Islam, Bangladesh
eP363 - Interleukin-10 expressing regulatory B cells are decreased in blood of smokers and COPD patients Merel Jacobs, Belgium
eP364 - Ferroptosis, induced by macrophages drives COPD pathogenesis Aicha Jeridi, Germany
eP366 - Exosomes from EGFR-mutated adenocarcinoma induce a partial/hybrid EMT Amina Jouida, Ireland
eP368 - Multi-omics analysis reveals the NAD+ salvage pathway as defense mechanism against Streptococcus pneumoniae infection Björn Klabunde, Germany
eP369 - DNA-viruses modulates changes in B cells phenotype and auto-Abs in asthma Anna Konishcheva, Russian Fed.
eP370 - Eosinophil-associated gene signature expression in U-BIOPRED severe asthma Janice Koranteng, United Kingdom
eP372 - IL11 negatively impacts adult lung alveolar organoid formation Rosa K. Kortekaas, Netherlands
eP373 - Assessment of mucosal and systemic phagocytosis in Health Care Professionals (HCPs) in the post COVID-19 period Nadezda Kryukova, Russian Fed.
eP374 - Radiation modulates bronchial epithelial progenitor activity as assessed in organoid formation assays Merian Kuipers, Netherlands
eP376 - Epithelial and neutrophil responses to microbes in cystic fibrosis airways Daniel Laucirica, Australia
eP377 - Characteristics of DNA repair capacity of peripheral blood lymphocytes from asthmatic patients with different phenotypes and severity Andrey Evgenievich Lintsov, Russian Fed.
eP378 - Cytogenetic Alterations In Cells from Allergic and Non-Allergic Asthmatic Patients Andrey Evgenievich Lintsov, Russian Fed.
eP379 - Phenotype and function of innate lymphoid cells in a murine model of impaired muco-ciliary clearance challenged with allergen Khatuna Lobjanidze, Germany
eP380 - Unravelling the role of miR-223 in the regulation of pollutant-aggravated allergic airway inflammation Rocio Teresa Martinez Nunez, United Kingdom
eP381 - Respiratory and systemic effect of diet and exercise in obese mice Fopke Marain, Belgium
eP382 - The RNA binding proteins ZFP36L1 and ZFP36L2 exert genome-wide effects on airways epithelium and glucocorticoid responses Rocio Teresa Martineunez, United Kingdom
eP383 - Production and delivery of a recombinant modified superoxide dismutase protein to a rodent ARDS model by vibrating mesh nebulisation Sean McCarthy, Ireland
eP384 - Validation of CXCL10 as a biomarker of respiratory tract infections detectable by lateral flow immunoassay Dayna Mikkelsen, Canada
eP385 - High-sensitivity TSLP assay demonstrates a role of TSLP in eosinophilic and non-eosinophilic asthma. Louise Munkholm Andreasson, Denmark
eP387 - Favipiravir induced rhabdomyolysis in patient with severe COVID-19 pneumonia Nurgul Naurzvai, Turkey
eP388 - IL-10 induced by alum-adjuvanted acellular pertussis vaccine reduces its capacity to induce protective respiratory tissue-resident CD4 T cells Caitlín Ní Chasaide, Ireland
eP389 - Persistent COVID-19 symptoms and quality of life among the Dutch pediatric population Lieke Noij, Netherlands
eP390 - Altered eicosanoid profile in association with nasal polyp severity in patients with chronic rhinosinusitis Axel Nordström, Sweden
eP391 - Airway hyperreactivity and type of acetylation as the predioctors of eosinophilic asthma in school-age children Yevehniya Ortemenka, Ukraine
eP392 - Influence of the long-term usage of inhaled corticosteroids on development of obesity and growth retardation in children with bronchial asthma Yevehniya Ortemenka, Ukraine
eP393 - A human ex vivo model to study the innate immune response to NTHi in the lung Lee Page, United Kingdom
eP395 - Allergic risk factors for severe asthma among preschool children: a descriptive-analytical study from rural Sri Lanka Shashanka Indeevara Rajapakse Rajapakse Mudiyanselage, Sri Lanka
eP396 - Comparing epithelial alarmin responses to different aeroallergens in bronchial epithelial cells from allergic asthma patients Sangeetha Ramu, Sweden
eP397 - Development of novel alveolar and bronchial microphysiological systems for use in disease research and drug development. Emily Richardson, United Kingdom
eP398 - Tissue resident memory T cells are increased in the lungs of COPD patients Bradley Richmond, USA
eP399 - Club cells are the primary source of pIgR in small airways Bradley Richmond, USA
eP400 - Seroprevalence of SARS-CoV-2 immunoglobulins in a community-based population in Tizi-Ouzou, Algeria. Salim Sadi, Algeria
eP402 - Farm dust exposure decreases expression of IL-33 in primary bronchial epithelial cells in part by inhibiting STAT1 phosphorylation Jasmijn A. Schrumpf, Netherlands
eP404 - Lung tuberculosis characteristics in association with herpesvirus infection Alexey Shibanov,
eP405 - Haemophilus influenzae is associated with fibrotic phenotype of COVID-19 and idiopathic pulmonary fibrosis. Pooja Shivshankar, USA
eP406 - LDH inhibition rescues pulmonary fibrosis features in human primary cellular models of IPF Wioletta Skronska-Wasek, Germany
eP407 - Inhalable textile microplastic fibers impair lung repair Shanshan Song, Netherlands
eP408 - The impact of nasal colonization with Staphylococcus aureus and its enterotoxin B on allergic airway inflammation in patients and mouse models Sabine Stegemann-Koniszewski, Germany
eP409 - Profibrotic and proinflammatory pulmonary response to bleomycin in a Swiss nude mice model Kristiyan Stiliyanov Atanasov, Spain
eP410 - Course of lung inflammation and injury caused by nanoparticle inhalation depends on material specific cellular perturbation pattern Tobias Stoeger, Germany
eP412 - Altered hyaluronan metabolism in response to IL1ß in the lung microenvironment is associated with defective repair Vasili Stylianidis, Netherlands
eP414 - The bronchodilatory and anti-inflammatory effect of TRPV4 ion channels blocker in experimentally-induced allergic asthma. Martina Šutovská, Slovakia
eP415 - Investigation of the interplay of pattern recognition receptors in IFN responses in bronchial epithelial cells from asthma patients Sofia Magdalena Tillgren, Sweden
eP416 - The role of mucosal IgE and cytokine levels in reflecting the intensity of allergic symptoms Joseph G S Tsun, Hong Kong
eP417 - Igf1r deficiency attenuates lung inflammation in a mice model of sub-chronic cigarette smoke exposure Alfredo Urtubia, Spain
eP418 - Association between serum IgG levels and time to first antibiotic prescription in COPD patients Anna Vanoverschelde, Belgium
eP419 - Partial apoptosis of epithelial cells in Idiopathic Pulmonary Fibrosis(IPF). Eirini Vasarmidi, France
eP420 - Exosomal miR16, miR21, miR126, miR146a and miR215 as biomarkers for asthma severity Sara Vázquez Mera, Spain
eP421 - IL1ß induces RANKL secretion in control but not COPD lung fibroblasts Jelmer Vlasma, Netherlands
eP422 - One drug to rule them all: Targeting host cell metabolic pathway to combat respiratory infections Laxmikant Wali, Austria
eP423 - Mucosal immunology of the gut and lung in a cigarette smoke-induced murine model for COPD: the lung-gut axis Lei Wang, Netherlands
eP424 - Deep learning in pulmonary drug delivery Lin Yang, Germany
eP425 - Fibroblasts drive the differentiation of murine pneumocytes in air-liquid interface cultures Yiwen Yao, Germany
eP426 - Prevalence and associated risk factors of post covid-19 interstitial lung disease; An emerging challenge to pulmonologists Duminda Yasaratne, Sri Lanka
eP427 - Outpatient antibiotic therapy leads to endotoxemia markers elevation in acute SARS-CoV-2 lung damage Igor Yatskov, Ukraine
eP428 - Local and systemic responses to SARS-CoV-2 infection in children and adults Masahiro Yoshida, United Kingdom