February

Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy Elena Ortona, Walter Malorni Eur Respir J, 59 (2) 2102245; 10.1183/13993003.02245-2021
Prognostic factors for adverse outcomes in patients with COVID-19: a field-wide systematic review and meta-analysis Vanesa Bellou, Ioanna Tzoulaki, Maarten van Smeden, Karel G.M. Moons, Evangelos Evangelou, Lazaros Belbasis Eur Respir J, 59 (2) 2002964; 10.1183/13993003.02964-2020
Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study Ismail M. Osmanov, Ekaterina Spiridonova, Polina Bobkova, Aysylu Gamirova, Anastasia Shikhaleva, Margarita Andreeva, Oleg Blyuss, Yasmin El-Taravi, Audrey DunnGalvin, Pasquale Comberiati, Diego G. Peroni, Christian Apfelbacher, Jon Genuneit, Lyudmila Mazankova, Alexandra Miroshina, Evgeniya Chistyakova, Elmira Samitova, Svetlana Borzakova, Elena Bondarenko, Anatoliy A. Korsunskiy, Irina Konova, Sarah Wulf Hanson, Gail Carson, Louise Sigfrid, Janet T. Scott, Matthew Greenhawt, Elizabeth A. Whittaker, Elena Garralda, Olivia V. Swann, Danilo Buonsenso, Dasha E. Nicholls, Frances Simpson, Christina Jones, Malcolm G. Semple, John O. Warner, Theo Vos, Piero Olliaro, Daniel Munblit Eur Respir J, 59 (2) 2101341; 10.1183/13993003.01341-2021
Predicting the risk of respiratory distress in newborns with congenital pulmonary malformations Christophe Delacourt, Nathalie Bertille, Laurent J. Salomon, Makan Rahshenas, Alexandra Benachi, Arnaud Bonnard, Laure Choupeaux, Virginie Fouquet, Valérie Goua, Frédéric Hameury, Erik Hervieux, Jean-Marie Jouannic, Naziha Khen-Dunlop, Gwenaelle Le Bouar, Jérôme Massardier, Léa Roditis, Jonathan Rosenblatt, Agnès Sartor, Catherine Thong-Vanh, Nathalie Lelong, Babak Khoshnood Eur Respir J, 59 (2) 2100949; 10.1183/13993003.00949-2021
Effects of nintedanib by inclusion criteria for progression of interstitial lung disease Toby M. Maher, Kevin K. Brown, Michael Kreuter, Anand Devaraj, Simon L.F. Walsh, Lisa H. Lancaster, Elizabeth A. Belloli, Maria Padilla, Juergen Behr, Rainer-Georg Goeldner, Kay Tetzlaff, Rozsa Schlenker-Herceg, Kevin R. Flaherty Eur Respir J, 59 (2) 2004587; 10.1183/13993003.04587-2020
Multi-omics profiling predicts allograft function after lung transplantation Martin L. Watzenboeck, Anna-Dorothea Gorki, Federica Quattrone, Riem Gawish, Stefan Schwarz, Christopher Lambers, Peter Jaksch, Karin Lakovits, Sophie Zahalka, Nina Rahimi, Philipp Starkl, Dörte Symmank, Tyler Artner, Céline Pattaroni, Nikolaus Fortelny, Kristaps Klavins, Florian Frommlet, Benjamin J. Marsland, Konrad Hoetzenecker, Stefanie Widder, Sylvia Knapp Eur Respir J, 59 (2) 2003292; 10.1183/13993003.03292-2020
Physical activity, sedentary behaviour and incidence of obstructive sleep apnoea in three prospective US cohorts Yue Liu, Lin Yang, Meir J. Stampfer, Susan Redline, Shelley S. Tworoger, Tianyi Huang Eur Respir J, 59 (2) 2100606; 10.1183/13993003.00606-2021
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration Cameron B. Morrison, Kendall M. Shaffer, Kenza C. Araba, Matthew R. Markovetz, Jason A. Wykoff, Nancy L. Quinney, Shuyu Hao, Martial F. Delion, Alexis L. Flen, Lisa C. Morton, Jimmy Liao, David B. Hill, Mitchell L. Drumm, Wanda K. O'Neal, Mehmet Kesimer, Martina Gentzsch, Camille Ehre Eur Respir J, 59 (2) 2100185; 10.1183/13993003.00185-2021
Evaluation of the PADIS score stratifying risk for venous thromboembolism recurrence after a first unprovoked pulmonary embolism: results from the REVERSE study Lucia Caiano, Rhys Sharkey, Marc A. Rodger, Michael J. Kovacs, Grégoire Le Gal, Aurélien Delluc Eur Respir J, 59 (2) 2101801; 10.1183/13993003.01801-2021
A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany Christina Bahrs, Miriam Kesselmeier, Martin Kolditz, Santiago Ewig, Gernot Rohde, Grit Barten-Neiner, Jan Rupp, Martin Witzenrath, Tobias Welte, Mathias W. Pletz Eur Respir J, 59 (2) 2102432; 10.1183/13993003.02432-2021
Remote patient monitoring in COVID 19: a critical appraisal Henri Gruwez, Emma Bakelants, Pauline Dreesen, Jolien Broekmans, Maarten Criel, Michiel Thomeer, Pieter Vandervoort, David Ruttens Eur Respir J, 59 (2) 2102697; 10.1183/13993003.02697-2021
Convalescent plasma for SARS-CoV-2 infection: win or learn Enric Contreras-Barbeta, Anna Millan, Jordi Rello Eur Respir J, 59 (2) 2102076; 10.1183/13993003.02076-2021
The quest for biomarkers in asthma: challenging the T2 versus non-T2 paradigm Sven F. Seys, Merete B. Long Eur Respir J, 59 (2) 2102669; 10.1183/13993003.02669-2021
ECMO during the COVID-19 pandemic: moving from rescue therapy to more reasonable indications Christian Karagiannidis, Thomas Bein, Tobias Welte Eur Respir J, 59 (2) 2103262; 10.1183/13993003.03262-2021
Convalescent plasma for COVID-19 in hospitalised patients: an open-label, randomised clinical trial Leo Sekine, Beatriz Arns, Bruna R. Fabro, Murillo M. Cipolatt, Rafael R.G. Machado, Edison L. Durigon, Edino Parolo, José Augusto S. Pellegrini, Marina V. Viana, Patrícia Schwarz, Thiago C. Lisboa, José Miguel S. Dora, Julia P. Portich, Alessandra A. Paz, Lucia Silla, Almeri M. Balsan, Felipe da-Silva Schirmer, Juliana P.M. Franz, Luciana M. da-Silveira, Raquel C. Breunig, Viviana Petersen, Monalisa Sosnoski, Nanci F. Mesquita, Fabiana Caroline Z. Volpato, Daniel Sganzerla, Maicon Falavigna, Regis G. Rosa, Alexandre P. Zavascki Eur Respir J, 59 (2) 2101471; 10.1183/13993003.01471-2021
Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma Timothy Devos, Quentin Van Thillo, Veerle Compernolle, Tomé Najdovski, Marta Romano, Nicolas Dauby, Laurent Jadot, Mathias Leys, Evelyne Maillart, Sarah Loof, Lucie Seyler, Martial Moonen, Michel Moutschen, Niels Van Regenmortel, Kevin K. Ariën, Cyril Barbezange, Albrecht Betrains, Mutien Garigliany, Matthias M. Engelen, Iwein Gyselinck, Piet Maes, Alexander Schauwvlieghe, Laurens Liesenborghs, Ann Belmans, Peter Verhamme, Geert Meyfroidt Eur Respir J, 59 (2) 2101724; 10.1183/13993003.01724-2021
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation Maria Sparreman Mikus, Johan Kolmert, Lars I. Andersson, Jörgen Östling, Richard G. Knowles, Cristina Gómez, Magnus Ericsson, John-Olof Thörngren, Payam Emami Khoonsari, Barbro Dahlén, Maciej Kupczyk, Bertrand De Meulder, Charles Auffray, Per S. Bakke, Bianca Beghe, Elisabeth H. Bel, Massimo Caruso, Pascal Chanez, Bo Chawes, Stephen J. Fowler, Mina Gaga, Thomas Geiser, Mark Gjomarkaj, Ildikó Horváth, Peter H. Howarth, Sebastian L. Johnston, Guy Joos, Norbert Krug, Paolo Montuschi, Jacek Musial, Ewa Nizankowska-Mogilnicka, Henric K. Olsson, Alberto Papi, Klaus F. Rabe, Thomas Sandström, Dominick E. Shaw, Nikolaos M. Siafakas, Mathias Uhlén, John H. Riley, Stewart Bates, Roelinde J.M. Middelveld, Craig E. Wheelock, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Peter Nilsson, Sven-Erik Dahlén, Anna James Eur Respir J, 59 (2) 2100142; 10.1183/13993003.00142-2021
Prenatal tobacco exposure and risk of asthma and allergy outcomes in childhood Rikke Bjersand Sunde, Jonathan Thorsen, Casper-Emil Tingskov Pedersen, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes, Hans Bisgaard Eur Respir J, 59 (2) 2100453; 10.1183/13993003.00453-2021
Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism David Jiménez, Carmen Rodríguez, Francisco León, Luis Jara-Palomares, Raquel López-Reyes, Pedro Ruiz-Artacho, Teresa Elías, Remedios Otero, Alberto García-Ortega, Agustina Rivas-Guerrero, Jaime Abelaira, Sonia Jiménez, Alfonso Muriel, Raquel Morillo, Deisy Barrios, Raphael Le Mao, Roger D. Yusen, Behnood Bikdeli, Manuel Monreal, José Luis Lobo Eur Respir J, 59 (2) 2100412; 10.1183/13993003.00412-2021
Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study Tomoko Nakanishi, Agustin Cerani, Vincenzo Forgetta, Sirui Zhou, Richard J. Allen, Olivia C. Leavy, Masaru Koido, Deborah Assayag, R. Gisli Jenkins, Louise V. Wain, Ivana V. Yang, G. Mark Lathrop, Paul J. Wolters, David A. Schwartz, J. Brent Richards Eur Respir J, 59 (2) 2003979; 10.1183/13993003.03979-2020
Efficacy and safety of inhaled ENaC inhibitor BI 1265162 in patients with cystic fibrosis: BALANCE-CF 1, a randomised, phase II study Christopher H. Goss, Isabelle Fajac, Raksha Jain, Wolfgang Seibold, Abhya Gupta, Ming-Chi Hsu, Sivagurunathan Sutharsan, Jane C. Davies, Marcus A. Mall Eur Respir J, 59 (2) 2100746; 10.1183/13993003.00746-2021
Associations of genetic risk and smoking with incident COPD Pei-Dong Zhang, Xi-Ru Zhang, Ao Zhang, Zhi-Hao Li, Dan Liu, Yu-Jie Zhang, Chen Mao Eur Respir J, 59 (2) 2101320; 10.1183/13993003.01320-2021
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia Dharmesh Hirani, Cristina M. Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr, Katharina Dinger, Christina Vohlen, Jaco Selle, Silke v. Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S. Pryhuber, Siavash Mansouri, Rajkumar Savai, Werner Seeger, Purvesh Khatri, Denise Al Alam, Jörg Dötsch, Miguel A. Alejandre Alcazar Eur Respir J, 59 (2) 2002248; 10.1183/13993003.02248-2020
Alpha-1 antitrypsin deficiency: clarifying the role of the putative protective threshold Alessandro N. Franciosi, Daniel Fraughen, Tomás P. Carroll, Noel G. McElvaney Eur Respir J, 59 (2) 2101410; 10.1183/13993003.01410-2021
High-dose versus low-dose prednisolone in symptomatic patients with post-COVID-19 diffuse parenchymal lung abnormalities: an open-label, randomised trial (the COLDSTER trial) Sahajal Dhooria, Shivani Chaudhary, Inderpaul Singh Sehgal, Ritesh Agarwal, Siddhant Arora, Mandeep Garg, Nidhi Prabhakar, Goverdhan Dutt Puri, Ashish Bhalla, Vikas Suri, Lakshmi Narayana Yaddanapudi, Valliappan Muthu, Kuruswamy Thurai Prasad, Ashutosh Nath Aggarwal Eur Respir J, 59 (2) 2102930; 10.1183/13993003.02930-2021
Risk factors for mortality in patients with COVID-19 needing extracorporeal respiratory support Jordi Riera, Sara Alcántara, Camilo Bonilla, Phillip Fortuna, Aaron Blandino Ortiz, Ana Vaz, Carlos Albacete, Pablo Millán, Pilar Ricart, María Victoria Boado, Pablo Ruiz de Gopegui, Patricia Santa Teresa, Elena Sandoval, Helena Pérez-Chomón, Alfredo González-Pérez, Jorge Duerto, Ricardo Gimeno, Joaquín Colomina, Vanesa Gómez, Gloria Renedo, José Naranjo, Manuel Alfonso García, Emilio Rodríguez-Ruiz, Pedro Eduardo Silva, Daniel Pérez, Javier Veganzones, Roberto Voces, Sergi Martínez, Pablo Blanco-Schweizer, Marta García, Héctor Villanueva-Fernández, María Paz Fuset, Stephani María Luna, María Martínez-Martínez, Eduard Argudo, Luis Chiscano, Roberto Roncon-Albuquerque Jr Eur Respir J, 59 (2) 2102463; 10.1183/13993003.02463-2021
Higher frequency of comorbidities in fully vaccinated patients admitted to the ICU due to severe COVID-19: a prospective, multicentre, observational study Anna Motos, Alexandre López-Gavín, Jordi Riera, Adrián Ceccato, Laia Fernández-Barat, Jesús F. Bermejo-Martin, Ricard Ferrer, David de Gonzalo-Calvo, Rosario Menéndez, Raquel Pérez-Arnal, Dario García-Gasulla, Alejandro Rodriguez, Oscar Peñuelas, José Ángel Lorente, Raquel Almansa, Albert Gabarrus, Judith Marin-Corral, Pilar Ricart, Ferran Roche-Campo, Susana Sancho Chinesta, Lorenzo Socias, Ferran Barbé, Antoni Torres Eur Respir J, 59 (2) 2102275; 10.1183/13993003.02275-2021
High-sensitive cardiac troponin after CPAP in obstructive sleep apnoea: the adjusted analytical change limit (adjACL) for small variations at low concentrations Denis Monneret Eur Respir J, 59 (2) 2103022; 10.1183/13993003.03022-2021
Reply: High-sensitive cardiac troponin after CPAP in obstructive sleep apnoea Mary Sau-Man Ip, Hung-Fat Tse, David Chi-Leung Lam, Macy Mei-Sze Lui Eur Respir J, 59 (2) 2103176; 10.1183/13993003.03176-2021
Comparison of the treatment guidelines for sarcoidosis: common sense in the search for evidence Vivienne Kahlmann, Catharina C. Moor, Jelle R. Miedema, Marlies S. Wijsenbeek Eur Respir J, 59 (2) 2103114; 10.1183/13993003.03114-2021
Management of recurrent transudative pleural effusions: can we REDUCE unnecessary interventions? Christopher R. Gilbert, José M. Porcel Eur Respir J, 59 (2) 2101942; 10.1183/13993003.01942-2021
Prone positioning for non-intubated hypoxaemic patients with COVID-19: cheap, easy and makes sense, but does it work? Eric D. Morrell, Mark M. Wurfel Eur Respir J, 59 (2) 2102416; 10.1183/13993003.02416-2021
In vitro assessment of triple combination therapy for the most common disease-associated mutation in cystic fibrosis Han-I Yeh, Tzyh-Chang Hwang Eur Respir J, 59 (2) 2102380; 10.1183/13993003.02380-2021
Does acute and persistent metabolic dysregulation in COVID-19 point to novel biomarkers and future therapeutic strategies? Emily M. Hartsell, Mark N. Gillespie, Raymond J. Langley Eur Respir J, 59 (2) 2102417; 10.1183/13993003.02417-2021
Randomised trial of indwelling pleural catheters for refractory transudative pleural effusions Steven P. Walker, Oliver Bintcliffe, Emma Keenan, Louise Stadon, Matthew Evison, Mohammed Haris, Thapas Nagarajan, Alex West, Alina Ionescu, Benjamin Prudon, Anur Guhan, Rehan Mustafa, Jurgen Herre, David Arnold, Rahul Bhatnagar, Brennan Kahan, Robert F. Miller, Najib M. Rahman, Nick A. Maskell Eur Respir J, 59 (2) 2101362; 10.1183/13993003.01362-2021
Awake prone positioning and oxygen therapy in patients with COVID-19: the APRONOX study Orlando R. Perez-Nieto, Diego Escarraman-Martinez, Manuel A. Guerrero-Gutierrez, Eder I. Zamarron-Lopez, Javier Mancilla-Galindo, Ashuin Kammar-García, Miguel A. Martinez-Camacho, Ernesto Deloya-Tomás, Jesús S. Sanchez-Díaz, Luis A. Macías-García, Raúl Soriano-Orozco, Gabriel Cruz-Sánchez, José D. Salmeron-Gonzalez, Marco A. Toledo-Rivera, Ivette Mata-Maqueda, Luis A. Morgado-Villaseñor, Jenner J. Martinez-Mazariegos, Raymundo Flores Ramirez, Josue L. Medina-Estrada, Silvio A. Ñamendys-Silva Eur Respir J, 59 (2) 2100265; 10.1183/13993003.00265-2021
The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor Frédéric Becq, Sandra Mirval, Thomas Carrez, Manuella Lévêque, Arnaud Billet, Christelle Coraux, Edouard Sage, Anne Cantereau Eur Respir J, 59 (2) 2100671; 10.1183/13993003.00671-2021
Metabolomic analyses reveal new stage-specific features of COVID-19 Hongling Jia, Chaowu Liu, Dantong Li, Qingsheng Huang, Dong Liu, Ying Zhang, Chang Ye, Di Zhou, Yang Wang, Yanlian Tan, Kuibiao Li, Fangqin Lin, Haiqing Zhang, Jingchao Lin, Yang Xu, Jingwen Liu, Qing Zeng, Jian Hong, Guobing Chen, Hao Zhang, Lingling Zheng, Xilong Deng, Changwen Ke, Yunfei Gao, Jun Fan, Biao Di, Huiying Liang Eur Respir J, 59 (2) 2100284; 10.1183/13993003.00284-2021
Restrictive spirometry pattern and abnormal cardiopulmonary response to exercise in transthyretin cardiac amyloidosis Rishika Banydeen, Giuseppe Vergaro, Antoine Deney, Astrid Monfort, Michele Emdin, Olivier Lairez, Anna Gaelle Giguet, Jocelyn Inamo, Remi Neviere Eur Respir J, 59 (2) 2102838; 10.1183/13993003.02838-2021
ORF8/ORF8a: a difference between SARS-CoV-2 and SARS-CoV Milad Zandi Eur Respir J, 59 (2) 2102818; 10.1183/13993003.02818-2021