October

The search for realistic evidence on the outcomes of obstructive sleep apnoea Sophia Schiza, Patrick Lévy, Miguel Angel Martinez-Garcia, Jean-Louis Pepin, Anita Simonds, Winfried Randerath Eur Respir J, 58 (4) 2101963; 10.1183/13993003.01963-2021
Improving ethnic diversity in respiratory genomics research Martin D. Tobin, Abril G. Izquierdo Eur Respir J, 58 (4) 2101615; 10.1183/13993003.01615-2021
Unravelling the unmet needs of patients with severe dyspnoea: a case for palliative oxygen Abebaw Mengistu Yohannes Eur Respir J, 58 (4) 2100775; 10.1183/13993003.00775-2021
IL-6 trans-signalling: how Haemophilus surfs the NET to amplify inflammation in COPD Holly R. Keir, James D. Chalmers Eur Respir J, 58 (4) 2102143; 10.1183/13993003.02143-2021
Understanding the impact of the lung microenvironment to enhance the therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome Claire Masterson, Hector Gonzalez, John G. Laffey Eur Respir J, 58 (4) 2100986; 10.1183/13993003.00986-2021
A new piece in the puzzle: the eosinophil and the development of COPD Nayia Petousi, Abigail Wooden, Richard E.K. Russell Eur Respir J, 58 (4) 2101105; 10.1183/13993003.01105-2021
Human experimental models: seeking to enhance multiscale research in sleep apnoea Ramon Farré, David Gozal, Isaac Almendros Eur Respir J, 58 (4) 2101169; 10.1183/13993003.01169-2021
A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang Eur Respir J, 58 (4) 2100199; 10.1183/13993003.00199-2021
Perspectives on palliative oxygen for breathlessness: systematic review and meta-synthesis Slavica Kochovska, Diana H. Ferreira, Maja V. Garcia, Jane L. Phillips, David C. Currow Eur Respir J, 58 (4) 2004613; 10.1183/13993003.04613-2020
The early use of Antibiotics for at Risk CHildren with InfluEnza-like illness (ARCHIE): a double-blind randomised placebo-controlled trial Kay Wang, Malcolm G. Semple, Michael Moore, Alastair D. Hay, Sharon Tonner, Ushma Galal, Jenna Grabey, Tricia Carver, Rafael Perera, Ly-Mee Yu, Jill Mollison, Paul Little, Andrew Farmer, Christopher C. Butler, Anthony Harnden Eur Respir J, 58 (4) 2002819; 10.1183/13993003.02819-2020
The risk of community-acquired pneumonia in children using gastric acid suppressants Linda J.T.M. van der Sande, Quirijn Jöbsis, Michiel A.G.E. Bannier, Ewoudt M.W. van de Garde, Jan J.M. Coremans, Frank de Vries, Edward Dompeling, Johanna H.M. Driessen Eur Respir J, 58 (4) 2003229; 10.1183/13993003.03229-2020
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca Riise, Suado Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda Yrlid, Elisabeth Ax, Ratko Djukanovic, Sriram Sridhar, Andrew Higham, Dave Singh, Thomas Southworth, Christopher E. Brightling, Henric K. Olsson, Zala Jevnikar Eur Respir J, 58 (4) 2003312; 10.1183/13993003.03312-2020
Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells Sara Rolandsson Enes, Thomas H. Hampton, Jayita Barua, David H. McKenna, Claudia C. dos Santos, Eyal Amiel, Alix Ashare, Kathleen D. Liu, Anna D. Krasnodembskaya, Karen English, Bruce A. Stanton, Patricia R.M. Rocco, Michael A. Matthay, Daniel J. Weiss Eur Respir J, 58 (4) 2004149; 10.1183/13993003.04149-2020
Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia Dani Do Hyang Lee, Daniela Cardinale, Ersilia Nigro, Colin R. Butler, Andrew Rutman, Mahmoud R. Fassad, Robert A. Hirst, Dale Moulding, Alexander Agrotis, Elisabeth Forsythe, Daniel Peckham, Evie Robson, Claire M. Smith, Satyanarayana Somavarapu, Philip L. Beales, Stephen L. Hart, Sam M. Janes, Hannah M. Mitchison, Robin Ketteler, Robert E. Hynds, Christopher O'Callaghan Eur Respir J, 58 (4) 2000455; 10.1183/13993003.00455-2020
Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study Hye Yun Park, Yoosoo Chang, Danbee Kang, Yun Soo Hong, Di Zhao, Jiin Ahn, Sun Hye Shin, Dave Singh, Eliseo Guallar, Juhee Cho, Seungho Ryu Eur Respir J, 58 (4) 2003823; 10.1183/13993003.03823-2020
VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability Olfa Harki, Renaud Tamisier, Jean-Louis Pépin, Sébastien Bailly, Anissa Mahmani, Brigitte Gonthier, Aude Salomon, Isabelle Vilgrain, Gilles Faury, Anne Briançon-Marjollet Eur Respir J, 58 (4) 2004518; 10.1183/13993003.04518-2020
Impact of obstructive sleep apnoea and intermittent hypoxia on blood rheology: a translational study Xavier Waltz, Andrew E. Beaudin, Elise Belaidi, Jill Raneri, Jean-Louis Pépin, Vincent Pialoux, Patrick J. Hanly, Samuel Verges, Marc J. Poulin Eur Respir J, 58 (4) 2100352; 10.1183/13993003.00352-2021
Digital-Rapid On-site Examination in Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (DEBUT): a proof of concept study for the application of artificial intelligence in the bronchoscopy suite Shahir Asfahan, Poonam Elhence, Naveen Dutt, Ram Niwas Jalandra, Nishant Kumar Chauhan Eur Respir J, 58 (4) 2100915; 10.1183/13993003.00915-2021
Standard pleural interventions are not high-risk aerosol generating procedures David T. Arnold, Florence K.A. Gregson, Sadiyah Sheikh, Fergus W. Hamilton, Hugh Welch, Alexandra Dipper, George W. Nava, James W. Dodd, Amelia O. Clive, Bryan R. Bzdek, Jonathan P. Reid, Nick A. Maskell Eur Respir J, 58 (4) 2101064; 10.1183/13993003.01064-2021
A phase 2 multiple ascending dose study of the inhaled pan-JAK inhibitor nezulcitinib (TD-0903) in severe COVID-19 Dave Singh, Maxim Bogus, Valentyn Moskalenko, Robert Lord, Edmund J. Moran, Glenn D. Crater, David L. Bourdet, Nathan D. Pfeifer, Jacky Woo, Elad Kaufman, David A. Lombardi, Emily Y. Weng, Tuan Nguyen, Ashley Woodcock, Brett Haumann, Rajeev Saggar Eur Respir J, 58 (4) 2100673; 10.1183/13993003.00673-2021
Impact of baseline patient characteristics on dupilumab efficacy in type 2 asthma William W. Busse, Pierluigi Paggiaro, Xavier Muñoz, Thomas B. Casale, Mario Castro, G. Walter Canonica, Jo A. Douglass, Yuji Tohda, Nadia Daizadeh, Benjamin Ortiz, Nami Pandit-Abid Eur Respir J, 58 (4) 2004605; 10.1183/13993003.04605-2020
Steroid use in elderly critically ill COVID-19 patients Christian Jung, Bernhard Wernly, Jesper Fjølner, Raphael Romano Bruno, David Dudzinski, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten Eur Respir J, 58 (4) 2100979; 10.1183/13993003.00979-2021
Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: an F-MISO PET/CT study Joanna C. Porter, Thida Win, Kjell Erlandsson, Francesco Fraioli, Alaleh Rashidnasab, Beverley Holman, Balaji Ganeshan, Nicholas J. Screaton, Toby M. Maher, Raymond Endozo, John Hoath, Robert I. Shortman, Elise Emond, Kris Thielemans, Brian F. Hutton, Pauline T. Lukey, Franklin Aigbirhio, Saif Khan, Manuel Rodriguez-Justo, Ashley M. Groves Eur Respir J, 58 (4) 2004584; 10.1183/13993003.04584-2020
The Cochrane review of electronic cigarettes for smoking cessation: remaining focused on the evidence Caitlin Notley, Ailsa R. Butler, Nicola Lindson, Chris Bullen, Annika Theodoulou, Rachna Begh, Hayden McRobbie, Peter Hajek, Nancy Rigotti, Jamie Hartman-Boyce Eur Respir J, 58 (4) 2102117; 10.1183/13993003.02117-2021