Novel mechanisms elucidated by translational studies of COPD

Poster Discussion
Chairs: C. Bingle (Sheffield (South Yorkshire), United Kingdom), N. Reynaert (Maastricht, Netherlands)

LSC - 2019 - STAT-3 is activated in COPD airway epithelial cells. F. Carlier (Brussels, Belgium), B. Detry (Brussels, Belgium), Y. Sibille (Yvoir, Belgium), C. Pilette (Brussels, Belgium)
LSC - 2019 - Dysfunctional macrophage polarization in murine COPD exacerbation A. van der Veen (Groningen, Netherlands), M. Roffel (Groningen, Netherlands), M. De Jager (Groningen, Netherlands), C. Brandsma (Groningen, Netherlands), E. Post (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), L. De Groot (Amsterdam, Netherlands), I. Boudewijn (Groningen, Netherlands), R. Lutter (Amsterdam, Netherlands), K. Bracke (Ghent, Belgium), B. Melgert (Groningen, Netherlands), T. Maes (Ghent, Belgium), I. Heijink (Groningen, Netherlands)
LSC - 2019 - Unraveling the role of miR-223-3p in the regulation of airway inflammation in asthma and COPD M. Roffel (Groningen, Netherlands)
LSC - 2019 - Neutrophil-derived microvesicles are internalised by lung epithelial cells and induce inflammatory activation M. Long (Sheffield, United Kingdom), A. Ajikumar (Sheffield, United Kingdom), K. Lodge (Cambridge, United Kingdom), A. Condliffe (Sheffield, United Kingdom), V. Ridger (Sheffield, United Kingdom)
Oxygen desaturation is associated with fibrocyte activation via epidermal growth factor receptor/hypoxia-inducible factor(HIF)-1a axis in COPD C. Wang (Taipei, Taiwan), C. Lo (Taipei, Taiwan), J. He (Taipei, Taiwan), T. Huang (Taipei, Taiwan), K. Chung (London, United Kingdom)
Differential phosphorylation patterns of macrophage cytoskeletal proteins in COPD following phagocytosis K. Anders (London, United Kingdom), K. Belchamber (London, United Kingdom), P. Barnes (London, United Kingdom), L. Donnelly (London, United Kingdom)
Lysophosphatidylcholine acyltransferase in the development of lung emphysema Y. Mikami (Tokyo, Japan), K. Hosoki (Tokyo, Japan), H. Matsuzaki (Tokyo, Japan), K. Makita (Tokyo, Japan), N. Miyashita (Tokyo, Japan), T. Nagase (Tokyo, Japan)
Lysosomal dysfunction in COPD pathogenesis. N. Saito (Tokyo, Japan), J. Araya (Tokyo, Japan), A. Ito (Tokyo, Japan), Y. Hosaka (Tokyo, Japan), A. Ichikawa (Tokyo, Japan), T. Kadota (Tokyo, Japan), T. Nakano (Tokyo, Japan), M. Yoshida (Tokyo, Japan), Y. Fujita (Tokyo, Japan), H. Utsumi (Tokyo, Japan), M. Hashimoto (Tokyo, Japan), H. Wakui (Tokyo, Japan), S. Minagawa (Tokyo, Japan), H. Hara (Tokyo, Japan), T. Numata (Tokyo, Japan), Y. Kaneko (Tokyo, Japan), K. Kuwano (Tokyo, Japan)
Rhinovirus induced innate immune responses in the epithelium of severe COPD H. Guo-Parke (Belfast, United Kingdom), A. Mousnier (Belfast, United Kingdom), U. Power (Belfast, United Kingdom), S. Weldon (Belfast, United Kingdom), L. Borthwick (Newcastle, United Kingdom), A. Fisher (Newcastle, United Kingdom), C. Taggart (Belfast, United Kingdom), J. Kidney (Belfast, United Kingdom)
A high probability of short-range interactions between fibrocytes and CD8 T cells in chronic obstructive pulmonary disease (COPD) lungs E. Maurat (PESSAC, France), E. Eyraud (PESSAC, France), P. Girodet (PESSAC, France), M. Thumerel (PESSAC, France), P. Berger (PESSAC, France), I. Dupin (PESSAC, France)
Human lung CD1c dendritic cells orchestrate lymphoid neogenesis during COPD T. Naessens (Gothenburg, Sweden), Y. Morias (Gothenburg, Sweden), E. Hamrud (Gothenburg, Sweden), U. Gehrmann (Gothenburg, Sweden), J. Mattsson (Gothenburg, Sweden), G. Skogberg (Gothenburg, Sweden), E. Israelsson (Gothenburg, Sweden), K. Thörn (Gothenburg, Sweden), F. Melville (Southampton, United Kingdom), L. Seys (Ghent, Belgium), K. Bracke (Ghent, Belgium), K. Staples (Southampton, United Kingdom), D. Cunoosamy (Gothenburg, Sweden), G. Brusselle (Ghent, Belgium), B. Lambrecht (Ghent, Belgium)
Extracellular matrix molecules are differentially associated with airflow obstruction and lung parenchymal destruction in COPD E. Papakonstantinou (Basel/Thessaloniki, Switzerland), D. Schumann (Basel, Switzerland), D. Leeming (Herlev, Denmark), M. Tamm (Basel, Switzerland), M. Karsdal (Herlev, Denmark), D. Stolz (Basel, Switzerland)
Cigarette smoke decreases E-Cadherin expression downregulating FoxO3 in lung epithelial cells S. Di Vincenzo (Palermo, Italy), C. Sangiorgi (Palermo, Italy), M. Ferraro (Palermo, Italy), M. Gjomarkaj (Palermo, Italy), D. Ninaber (Leiden, Netherlands), P. Hiemstra (Leiden, Netherlands), E. Pace (Palermo, Italy)
Temporal analysis of the intracellular signaling pathways involved in Th17/Treg response in COPD development L. Emidio de França Silva (Sao Paulo, Brazil), J. Dias Lourenço (Sao Paulo, Brazil), K. Rodrigues Da Silva (Sao Paulo, Brazil), J. Benini Kohler (Sao Paulo, Brazil), F. Paula Roncon Santana (Sao Paulo, Brazil), A. Riani Moreira (Sao Paulo, Brazil), D. Aparecida De Brito Cervilha (Sao Paulo, Brazil), S. Sobral Hamaguchi (Sao Paulo, Brazil), C. Máximo Prado (Santos, Brazil), R. De Paula Vieira (Sao Paulo, Brazil), A. Pereira Velosa (Sao Paulo, Brazil), J. Ito (Sao Paulo, Brazil), F. Degobbi Tenorio Quirino Dos Santos Lopes (Sao Paulo, Brazil)
Wnt/ß-catenin signalling is upregulated in the COPD bronchial epithelium. F. Carlier (Brussels, Belgium), J. Ambroise (Brussels, Belgium), S. Dupasquier (Brussels, Belgium), B. Bearzatto (Brussels, Belgium), C. Pilette (Brussels, Belgium)
A subset of COPD patients defined by lung epithelial IL-6 trans-signalling is associated with neutrophilic inflammation and colonization by Haemophilus influenzae Z. Jevnikar Rojnik (Gothenburg, Sweden), S. Diver (Leicester , United Kingdom), C. Brightling (Leicester , United Kingdom), H. Olsson (Gothenburg, Sweden)
Exosomes are differentially present in bronchoalveolar lavage (BAL) of smokers and patients with COPD and IPF E. Bazzan (Padova, Italy), C. Radu (Padova, Italy), M. Tinè (Padova, Italy), E. Cocconcelli (Padova, Italy), D. Biondini (Padova, Italy), G. Turato (Padova, Italy), P. Simioni (Padova, Italy), M. Cosio (Montreal , Canada), M. Saetta (Padova, Italy)
Cathepsin S as a mediator of acute lung inflammation M. McKelvey (Belfast, United Kingdom), A. Abladey (Belfast, United Kingdom), R. Williams (Belfast, United Kingdom), C. O'Kane (Belfast, United Kingdom), D. Mc Auley (Belfast, United Kingdom), S. Weldon (Belfast, United Kingdom), C. Taggart (Belfast, United Kingdom)