Novel mechanisms for established drugs for asthma and COPD management

Oral Presentation
Chairs: I.M. Adcock (London, United Kingdom), G. Brusselle (Ghent, Belgium)

U-BIOPRED asthma cohort: Inflammatory markers and corticosteroid use D. Gibeon, A. H. Wagener, X. Yang, A. R. Sousa, J. Corfield, D. E. Shaw, S. Fowler, L. J. Fleming, J. Riley, E. Jeyasingham, A. Rowe, K. Fichtner, G. Roberts, P. Bakke, F. Singer, T. Geiser, U. Frey, I. Horvarth, R. Polosa, K. Bønnelykke, N. Krug, R. Middelveld, S. E. Dahlen, B. Dahlen, G. Hedlin, S. Hashimoto, B. Nordlund, J. Musial, A. Woodcock, C. S. Murray, L. Pahus, P. Chanez, D. Myles, C. Compton, T. W. Higenbottam, P. Montuschi, J. Vestbo, L. Larsson, T. Sandstrom, H. Bisgaard, S. S. Wagers, P. H. Howarth, E. H. Bel, R. Djukanovic, P. J. Sterk, K. F. Chung (London, Nottingham, Manchester, Southampton, Horsham, United Kingdom; Amsterdam, Netherlands; Lund, Stockholm, Umeå, Sweden; Ingelheim am Rhein, Hannover, Germany; Bergen, Hvidovre, Norway; Bern, Switzerland; Budapest, Hungary; Catania, Rome, Italy; Copenhagen, Denmark; Krakow, Poland; Marseille, France; Maasmechelen, Belgium)
Ciclesonide and tiotropium synergistically inhibit airway eosinophilia in a guinea pig model of chronic asthma S. Bos, H. Meurs, H. Maarsingh, M. Smit, A. Zuidhof, R. Gosens (Groningen, Netherlands)
Importin-7 knockdown reduces corticosteroid induced glucocorticoid receptor nuclear localisation and suppression of IL-1beta induced CXCL8 A. Hakim, P. Barnes, I. Adcock, O. Usmani (London, United Kingdom)
Involvement of the BK channels/G proteins processes in the synergistic effects between anticholinergic agents and beta2-adrenoceptor agonists in airway smooth muscle H. Kume, S. Imbe, T. Iwanaga, O. Nishiyama, H. Sano, Y. Tohda (Osakasayama, Japan)
Effects of combining tiotropium and salmeterol/fluticasone propionate on airway dimensions in patients with COPD M. Hoshino (Atami, Japan)
Efficacy of roflumilast with concomitant cardiovascular medication in patients with COPD P. Calverley, L. Fabbri, F. Martinez, U. M. Goehring, M. Brose, K. Rabe (Liverpool, United Kingdom; Modena, Italy; Ann Arbor, United States Of America; Zurich, Switzerland; Kiel, Germany)
Effects of aclidinium bromide on exercise endurance, dynamic hyperinflation, physical activity and exertional dyspnoea in patients with moderate to severe COPD K. M. Beeh, H. Watz, H. Magnussen, L. Puente-Maestu, D. Jarreta, C. Caracta, E. Garcia Gil (Wiesbaden, Grosshansdorf, Germany; Madrid, Barcelona, Spain; Jersey City, United States Of America)
Aclidinium bromide reduces extracellular matrix deposition by COPD-derived mesenchymal cells C. Lambers, Y. Qi, E. Papakonstantinou, E. Schuller, M. Roth, L. H. Block (Wien, Austria; Basel, Austria, Switzerland; Thessaloniki, Greece)