Cystic fibrosis: basic and applied science

Poster Discussion
Chairs: F. Ratjen (Toronto, Canada), D. Hartl (Tuebingen, Germany)

LATE-BREAKING ABSTRACT: Multiple breath washout is feasible and detects abnormal lung function in infants and young children with cystic fibrosis in the clinical setting M. Stahl, C. Joachim, K. Blessing, S. Hämmerling, O. Sommerburg, P. Latzin, M. Mall (Heidelberg, Germany; Bern, Switzerland)
LATE-BREAKING ABSTRACT: High expression of Midkine in the airways of patients with cystic fibrosis S. Jovic, S. Nordin, A. Egesten (Lund, Sweden)
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator (CFTR) ion transport S. V. Raju, P. Jackson, C. Courville, C. McNicholas, P. A. Sloane, G. Sabbatinin, L. P. Tang, M. Mazur, J. P. Clancy, F. J. Accurso, J. E. Blalock, M. T. Dransfield, S. M. Rowe (Birmingham, Denver, Cincinnati, United States Of America)
CFTR regulation by microRNA-145, -223 and -494 is altered in deltaF508 cystic fibrosis airway epithelium I. Oglesby, S. Chotirmall, N. McElvaney, C. Greene (Dublin, Ireland)
microRNA-mediated inhibition of IL-8 production from cystic fibrosis bronchial epithelial cells K. Gaughan, T. Hassan, R. Agarwal, M. Mall, N. McElvaney, C. Greene (Dublin, Ireland; Heidelberg, Germany)
MiR-145 and SMAD3 expression in patients with cystic fibrosis F. Megiorni, S. Cialfi, G. Cimino, R. V. De Biase, D. Savi, C. Dominici, A. Pizzuti, S. Quattrucci (Rome, Italy)
Defective A20 signalling in CF: Anti-inflammatory action of gibberellins C. Kelly, J. Reihill, B. Malconsom, A. Czerwiec, B. Hirsch, S. Elborn, M. Ennis, B. Schock (Keele, Belfast, United Kingdom; Berlin, Germany)
Enhanced expression of interleukin 8 (CXCL8) in cystic fibrosis (CF) airway epithelial (AE) cells A. Poghosyan, R. L. Clifford, W. R. Coward, L. Pang, A. J. Knox (Nottingham, United Kingdom)
The chemokine decoy PA401 decreases interleukin-8 and chemotactic activity of cystic fibrosis airway samples O. J. McElvaney, D. A. Bergin, T. Adage, J. H. Slingsby, A. J. Kungl, M. R. Bartley, E. P. Reeves, N. G. McElvaney (Dublin, Ireland; Reininghausstrasse, Austria)
Xylitol affects production of virulence factors and biofilm in pseudomonas aeruginosa; effects on respiratory epithelium inflammation. "In vitro" studies E. Mengoni, A. Dugour, A. Vojnov, J. Figueroa (Buenos Aires, Argentina)
Physicochemical properties of mucus gel in CF and healthy controls assessed by Raman spectroscopy and force-distance atomic force microscopy A. Malkovskiy, J. Zirbes, J. Rajadas, C. Milla (Palo Alto, United States Of America)
Anaerobic bacteria and host defence in cystic fibrosis A. Bertelsen, M. Ennis, S. Elborn (Belfast, United Kingdom)
Is the unbalance between arachidonic acid and docosahexaenoic acid a reversible condition in adults With cystic fibrosis? E. Teopompi, G. Pisi, M. Aiello, R. Pisi, P. Mangano, F. Longo, P. Rizè, C. Tripodi, V. Fainardi, E. Clini, A. Chetta, A. Sala (Parma, Milan, Modena, Italy)
Self-perceived verses electronic monitoring of adherence to nebulised treatment in children with cystic fibrosis - does the use of telehealth system improve nebulisation adherence? C. Thorton, N. Moss, E. Chan (Manchester, United Kingdom)
Airway surface liquid concentrations of aztreonam lysine for inhalation in children with cystic fibrosis: A modeling study C. Van Holsbeke, A. Bos, W. Vos, J. De Backer, H. Janssens, H. Tiddens (Kontich, Belgium; Rotterdam, Netherlands)
Combining inhalation by a breath-actuated nebulizer (BAN) with exhalation with oscillating positive expiratory pressure device (OPEP) offers potential for simultaneous therapy J. Suggett, J. Mitchell, V. Avvakoumova, R. Ali, H. Schneider (London, Canada)
A randomised comparison of two tobramycin formulations in cystic fibrosis (CF) patients with chronic pseudomonas aeruginosa (PA) infection for pharmacokinetic and therapeutic equivalence D. Sands, E. Sapiejka, H. Mazurek, G. Gaszczyk (Warsaw, Gdansk, Rabka, Karpacz, Poland)
Effect of I:E ratio on delivery of colistimethate sodium from breath-enhanced and breath-activated nebulizers S. Byrne, D. Jeffrey, R. Hatley (Chichester, United Kingdom)