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Novel mechanisms elucidated by translational studies of COPD

Poster Discussion
Chairs: C. Bingle (Sheffield (South Yorkshire), United Kingdom), N. Reynaert (Maastricht, Netherlands)


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 [+]  Congress or journal article abstract E-poster 1666 LSC - 2019 - STAT-3 is activated in COPD airway epithelial cells.
F. Carlier (Brussels, Belgium), B. Detry (Brussels, Belgium), Y. Sibille (Yvoir, Belgium), C. Pilette (Brussels, Belgium)
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 [+]  Congress or journal article abstract 1667 LSC - 2019 - Dysfunctional macrophage polarization in murine COPD exacerbation
A. van der Veen (Groningen, Netherlands), M. Roffel (Groningen, Netherlands), M. De Jager (Groningen, Netherlands), C. Brandsma (Groningen, Netherlands), E. Post (Groningen, Netherlands), M. Van Den Berge (Groningen, Netherlands), L. De Groot (Amsterdam, Netherlands), I. Boudewijn (Groningen, Netherlands), R. Lutter (Amsterdam, Netherlands), K. Bracke (Ghent, Belgium), B. Melgert (Groningen, Netherlands), T. Maes (Ghent, Belgium), I. Heijink (Groningen, Netherlands)
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 [+]  Congress or journal article abstract 1668 LSC - 2019 - Unraveling the role of miR-223-3p in the regulation of airway inflammation in asthma and COPD
M. Roffel (Groningen, Netherlands)
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 [+]  Congress or journal article abstract 1669 LSC - 2019 - Neutrophil-derived microvesicles are internalised by lung epithelial cells and induce inflammatory activation
M. Long (Sheffield, United Kingdom), A. Ajikumar (Sheffield, United Kingdom), K. Lodge (Cambridge, United Kingdom), A. Condliffe (Sheffield, United Kingdom), V. Ridger (Sheffield, United Kingdom)
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 [+]  Congress or journal article abstract 1670 Oxygen desaturation is associated with fibrocyte activation via epidermal growth factor receptor/hypoxia-inducible factor(HIF)-1a axis in COPD
C. Wang (Taipei, Taiwan), C. Lo (Taipei, Taiwan), J. He (Taipei, Taiwan), T. Huang (Taipei, Taiwan), K. Chung (London, United Kingdom)
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 [+]  Congress or journal article abstract 1671 Differential phosphorylation patterns of macrophage cytoskeletal proteins in COPD following phagocytosis
K. Anders (London, United Kingdom), K. Belchamber (London, United Kingdom), P. Barnes (London, United Kingdom), L. Donnelly (London, United Kingdom)
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 [+]  Congress or journal article abstract 1672 Lysophosphatidylcholine acyltransferase in the development of lung emphysema
Y. Mikami (Tokyo, Japan), K. Hosoki (Tokyo, Japan), H. Matsuzaki (Tokyo, Japan), K. Makita (Tokyo, Japan), N. Miyashita (Tokyo, Japan), T. Nagase (Tokyo, Japan)
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 [+]  Congress or journal article abstract 1673 Lysosomal dysfunction in COPD pathogenesis.
N. Saito (Tokyo, Japan), J. Araya (Tokyo, Japan), A. Ito (Tokyo, Japan), Y. Hosaka (Tokyo, Japan), A. Ichikawa (Tokyo, Japan), T. Kadota (Tokyo, Japan), T. Nakano (Tokyo, Japan), M. Yoshida (Tokyo, Japan), Y. Fujita (Tokyo, Japan), H. Utsumi (Tokyo, Japan), M. Hashimoto (Tokyo, Japan), H. Wakui (Tokyo, Japan), S. Minagawa (Tokyo, Japan), H. Hara (Tokyo, Japan), T. Numata (Tokyo, Japan), Y. Kaneko (Tokyo, Japan), K. Kuwano (Tokyo, Japan)
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 [+]  Congress or journal article abstract E-poster 1674 Rhinovirus induced innate immune responses in the epithelium of severe COPD
H. Guo-Parke (Belfast, United Kingdom), A. Mousnier (Belfast, United Kingdom), U. Power (Belfast, United Kingdom), S. Weldon (Belfast, United Kingdom), L. Borthwick (Newcastle, United Kingdom), A. Fisher (Newcastle, United Kingdom), C. Taggart (Belfast, United Kingdom), J. Kidney (Belfast, United Kingdom)
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 [+]  Congress or journal article abstract 1675 A high probability of short-range interactions between fibrocytes and CD8 T cells in chronic obstructive pulmonary disease (COPD) lungs
E. Maurat (PESSAC, France), E. Eyraud (PESSAC, France), P. Girodet (PESSAC, France), M. Thumerel (PESSAC, France), P. Berger (PESSAC, France), I. Dupin (PESSAC, France)
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 [+]  Congress or journal article abstract 1676 Human lung CD1c dendritic cells orchestrate lymphoid neogenesis during COPD
T. Naessens (Gothenburg, Sweden), Y. Morias (Gothenburg, Sweden), E. Hamrud (Gothenburg, Sweden), U. Gehrmann (Gothenburg, Sweden), J. Mattsson (Gothenburg, Sweden), G. Skogberg (Gothenburg, Sweden), E. Israelsson (Gothenburg, Sweden), K. Thörn (Gothenburg, Sweden), F. Melville (Southampton, United Kingdom), L. Seys (Ghent, Belgium), K. Bracke (Ghent, Belgium), K. Staples (Southampton, United Kingdom), D. Cunoosamy (Gothenburg, Sweden), G. Brusselle (Ghent, Belgium), B. Lambrecht (Ghent, Belgium)
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 [+]  Congress or journal article abstract 1677 Extracellular matrix molecules are differentially associated with airflow obstruction and lung parenchymal destruction in COPD
E. Papakonstantinou (Basel/Thessaloniki, Switzerland), D. Schumann (Basel, Switzerland), D. Leeming (Herlev, Denmark), M. Tamm (Basel, Switzerland), M. Karsdal (Herlev, Denmark), D. Stolz (Basel, Switzerland)
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 [+]  Congress or journal article abstract 1678 Cigarette smoke decreases E-Cadherin expression downregulating FoxO3 in lung epithelial cells
S. Di Vincenzo (Palermo, Italy), C. Sangiorgi (Palermo, Italy), M. Ferraro (Palermo, Italy), M. Gjomarkaj (Palermo, Italy), D. Ninaber (Leiden, Netherlands), P. Hiemstra (Leiden, Netherlands), E. Pace (Palermo, Italy)
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 [+]  Congress or journal article abstract E-poster 1679 Temporal analysis of the intracellular signaling pathways involved in Th17/Treg response in COPD development
L. Emidio de França Silva (Sao Paulo, Brazil), J. Dias Lourenço (Sao Paulo, Brazil), K. Rodrigues Da Silva (Sao Paulo, Brazil), J. Benini Kohler (Sao Paulo, Brazil), F. Paula Roncon Santana (Sao Paulo, Brazil), A. Riani Moreira (Sao Paulo, Brazil), D. Aparecida De Brito Cervilha (Sao Paulo, Brazil), S. Sobral Hamaguchi (Sao Paulo, Brazil), C. Máximo Prado (Santos, Brazil), R. De Paula Vieira (Sao Paulo, Brazil), A. Pereira Velosa (Sao Paulo, Brazil), J. Ito (Sao Paulo, Brazil), F. Degobbi Tenorio Quirino Dos Santos Lopes (Sao Paulo, Brazil)
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 [+]  Congress or journal article abstract E-poster 1680 Wnt/ß-catenin signalling is upregulated in the COPD bronchial epithelium.
F. Carlier (Brussels, Belgium), J. Ambroise (Brussels, Belgium), S. Dupasquier (Brussels, Belgium), B. Bearzatto (Brussels, Belgium), C. Pilette (Brussels, Belgium)
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 [+]  Congress or journal article abstract E-poster 1681 A subset of COPD patients defined by lung epithelial IL-6 trans-signalling is associated with neutrophilic inflammation and colonization by Haemophilus influenzae
Z. Jevnikar Rojnik (Gothenburg, Sweden), S. Diver (Leicester , United Kingdom), C. Brightling (Leicester , United Kingdom), H. Olsson (Gothenburg, Sweden)
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 [+]  Congress or journal article abstract 1682 Exosomes are differentially present in bronchoalveolar lavage (BAL) of smokers and patients with COPD and IPF
E. Bazzan (Padova, Italy), C. Radu (Padova, Italy), M. Tinè (Padova, Italy), E. Cocconcelli (Padova, Italy), D. Biondini (Padova, Italy), G. Turato (Padova, Italy), P. Simioni (Padova, Italy), M. Cosio (Montreal , Canada), M. Saetta (Padova, Italy)
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 [+]  Congress or journal article abstract E-poster 1683 Cathepsin S as a mediator of acute lung inflammation
M. McKelvey (Belfast, United Kingdom), A. Abladey (Belfast, United Kingdom), R. Williams (Belfast, United Kingdom), C. O'Kane (Belfast, United Kingdom), D. Mc Auley (Belfast, United Kingdom), S. Weldon (Belfast, United Kingdom), C. Taggart (Belfast, United Kingdom)
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