Research Seminars

About

Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.

Severe Asthma

The purpose of this Research Seminar was to bring together a group of experts and young investigators, review known data and present ongoing studies that help shed light on the mechanisms and course of severe asthma. The Research Seminar focused on the following objectives:

To discuss current knowledge and research on pathophysiological mechanisms, clinical heterogeneity and new management of severe asthma, and bring together physicians, scientists and research nurses involved in the field.
To enable young scientists and physicians from Europe to discuss with experts the potential role of inflammation and structural changes of the bronchi in the persistence and severity of asthma.
To point out the heterogeneity of the disease, including different phenotypes, and the crucial role of comorbidities interfering with a potential good control. The importance of a long-term follow-up with a clear strategy of action was emphasised.
To assess the importance of investigating new therapeutical avenues based on evidence, and to consider the potential for existing drugs and the development of innovative strategies.
To consider the need for a coherent assessment in a specialised centre using a variety of skills to appreciate therapeutic adherence, comorbidities, psychological factors and response to therapy. The role of long-term management with realistic objectives was discussed.

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Epidemiology and Triggers of Severe Asthma M. Gaga (Athens, Greece)
Severe Asthma: A Clinically Heterogeneous Entity E. Bel (Amsterdam, The Netherlands)
Co-Morbidities Are Serious Confounders of Asthma in Severe Asthma P. Godard (Montpellier, France)
Animal Models of Asthma, Inflammation and Remodeling G. Xanthou (Athens, Greece)
Endogenous Anti-Inflammatory Mechanisms and the Role of Lipoxins I. Vachier (Montpellier, France)
What Can Be Expected From Pathology Assessment? Or: Is Severe Asthma Still an Eosinophilic Disease? S. Wenzel (Pittsburgh, United States of America)
Inflammatory Pathways and Mediators in the Pathogenesis of Severe Asthma G. Joos (Ghent, Belgium)
How to Manage Severe Asthma, the Value of Inflammation Monitoring C. Brightling (Leicester, United Kingdom)
Severe Asthma, Current Options and Limitations of Pharmacotherapy C. Corrigan (London, United Kingdom)
Severe Asthma in Children A. Bush (London, United Kingdom)
Summing Up: A Global Management of Severe Asthma P. Chanez (Montpellier, France)