Research Seminars

About

Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.

Translational animal models of asthma

Animal models of asthma have proven to be very valuable for dissecting the cellular and molecular mechanisms and to explore novel therapeutic opportunities. However, our knowledge of the risk factors and the pathogenesis of asthma is continually evolving. Animal models of asthma have focused on Th2-driven disease manifestations although these models are not sufficient to cover the complexity of asthma (sub)phenotypes. Little attention is paid to the modeling of symptoms such as cough, dyspnea, bronchospasm with most of the focus being on inflammatory endpoints. Therefore, novel and improved translational models are needed. This Research Seminar aims to discuss the strengths and weaknesses of current animal models and compare these with clinical translational endpoints.

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Asthma S. Holgate (Southampton, United Kingdom)
European Asthma Research and Innovation Partnership (EARIP) S. Walker (London, United Kingdom)
Airway hyperreactivity in animal models A. Braun (Hannover, Germany)
Assessment of symptoms: Cough reflex and LAR M. Belvisi (London, United Kingdom)
Airway remodeling in mouse models C. Lloyd (London, United Kingdom)
Are Murine Models of Asthma enough C. Page (London, United Kingdom)
PAMPs and DAMPs in Allergy: Exacerbation Models M. Kool (Rotterdam, Netherlands)
The microbiology of asthma S.L. Johnston (London, United Kingdom)