International Congress Munich 2014


Pulmonary hypertension: novel targets and drugs

Thematic Poster Session
Chairs: W. Seeger (Giessen, Germany), M. Toshner (Cambridge, United Kingdom), R. Souza (Sao Paulo, Brazil), C. Guignabert (Le Plessis-Robinson, France)
Prevention of monocrotaline-induced pulmonary vascular and myocardial remodeling by the selective neutrophil elastase inhibitor BAY 85-8501
M. Delbeck, V. Li, F. Von Nussbaum, D. Meibom, S. Golz, K. Lustig, H. Truebel, S. Schaefer (Wuppertal, Germany)
Congress or journal article abstract
Congress or journal article abstract
Anti-contractile and anti-proliferative responses in human pulmonary arterial smooth muscle cells induced by ACT-333679, the active metabolite of selexipag, a non-prostanoid selective prostacyclin receptor agonist
J. Gatfield, K. Menyhart, O. Nayler (Allschwil, Switzerland)
Congress or journal article abstract
Congress or journal article abstract
Population pharmacokinetics (PK) of riociguat in patients (pts) with renal and hepatic impairment
S. Saleh, C. Becker, R. Frey, W. Mueck (Wuppertal, Germany)
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Comparison of current therapies against endothelin-induced growth in pulmonary smooth arterial muscle cells (PASMCs) derived from patients with pulmonary arterial hypertension
J. Patel, D. Abraham, A. Nelson, A. Silverstein, L. Clapp (London, United Kingdom; Durham, United States Of America)
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Prolonged activity of inhaled treprostinil prodrug nanoparticles in a rat model of pulmonary arterial hypertension
F. Leifer, D. Omiatek, V. Malinin, J. Ong, Z. Li, P. Klecha, R. Chapman, D. Salvail, C. Laurent, W. Perkins (Monmouth Junction, United States Of America; Sherbrooke, Canada)
Congress or journal article abstract
Congress or journal article abstract
Incorporation into lipid nanoparticles extends the duration of activity of treprostinil in an acute hypoxia rat model of pulmonary arterial hypertension
D. Omiatek, F. Leifer, V. Malinin, J. Ong, T. Henn, Z. Li, R. Chapman, D. Salvail, C. Laurent, W. Perkins (Monmouth Junction, United States Of America; Sherbrooke, Canada)
Congress or journal article abstract
Congress or journal article abstract
Treprostinil prodrugs for pulmonary arterial hypertension evaluated in cAMP profiling studies in live CHO-K1 cells
K. Chen, J. Ong, V. Malinin, F. Leifer, D. Omiatek, Z. Li, R. Chapman, W. Perkins, R. Gupta (Monmouth Junction, United States Of America)
Congress or journal article abstract
Congress or journal article abstract
MicroRNA-155 controls pulmonary artery fibroblast cell signalling and proliferation in a knockout mouse model: A role in pulmonary arterial hypertension
N. McGlinchey, C. Bradley, C. McSharry, A. Peacock, D. Welsh (Glasgow, United Kingdom)
Congress or journal article abstract
Congress or journal article abstract
Endothelial-to-mesenchymal transition in pulmonary hypertension
B. Ranchoux, C. Rucker-Martin, F. Antigny, C. Péchoux, A. Hautefort, H. J. Bogaard, P. Dorfmüller, F. Lecerf, N. Raymond, S. Chat, E. Fadel, A. Houssaini, S. Adnot, G. Simonneau, M. Humbert, S. Cohen-Kaminsky, F. Perros (Le Plessis-Robinson, Le Kremlin-Bicetre, Jouy-en-Josas, Créteil, France; Amsterdam, Netherlands)
Congress or journal article abstract
Congress or journal article abstract
Increased endothelial-derived microparticles in ventilator-induced lung injury
E. Letsiou, S. Sammani, J. G. Garcia, S. M. Dudek (Chicago, Tucson, United States Of America)
Congress or journal article abstract
Congress or journal article abstract
Immune signatures in pulmonary arterial hypertension
F. Perros, D. Montani, B. Girerd, A. Sefarian, P. Dorfmuller, I. Klingel-Schmitt, M. Vocelle, A. Courtier, O. Filipe-Santo, G. Parmentier, S. Perez, C. Suberbielle, S. Caillat-Zucman, G. Simonneau, M. Humbert, S. Cohen-Kaminsky (Le Plessis Robinson, Le Kremlin Bicêtre, Grenoble, Paris, France)
Congress or journal article abstract
Congress or journal article abstract
Molecular study of genetic modifiers in patients with pulmonary arterial hypertension
G. Pousada, A. Baloira, D. Valverde (Vigo, Pontevedra, Spain)
Congress or journal article abstract
Congress or journal article abstract
Female pulmonary arterial hypertension is associated with decreased microRNA96 expression
E. Wallace, K. Mair, L. Long, X. D. Yang, N. Morrell, A. H. Baker, M. R. MacLean (Glasgow, Cambridge, United Kingdom)
Congress or journal article abstract
Congress or journal article abstract
The flavonoid quercetin reverses monocrotaline-induced pulmonary hypertension
D. Morales-Cano, C. Menendez, J. Moral-Sanz, B. Barreira, R. Jimenez, L. Moreno, A. Cogolludo, J. Cortijo, J. Duarte, F. Perez-Vizcaino (Madrid, Granada, Valencia, Spain)
Congress or journal article abstract
Congress or journal article abstract
Smooth muscle microparticles as novel biomarkers of vascular remodelling and inflammation in pulmonary arterial hypertension
R. Gurung, L. Clapp, N. Klein (London, United Kingdom)
Congress or journal article abstract
Congress or journal article abstract
Treprostinil pharmacokinetics in rats are extended using inhaled prodrug formulations
V. Malinin, Z. Li, R. Chapman, F. Leifer, D. Omiatek, J. Ong, D. Salvail, C. Laurent, W. Perkins (Monmouth Junction, United States Of America; Sherbrooke, Canada)
Congress or journal article abstract
Congress or journal article abstract
Neuron-derived orphan receptor 1 mediated human pulmonary arterial smooth muscle cells proliferation via cyclin D1
D. X. Zeng, C. G. Wang, W. Lei, J. A. Huang (Suzhou, China)
Congress or journal article abstractE-poster
Congress or journal article abstractE-poster
Expression and role of the nerve growth factor NGF in severe pulmonary hypertension
F. Coste, C. Toussaint, M. Dubois, A. Courtois, C. Guibert, R. Marthan, J. P. Savineau, B. Muller, V. Freund-Michel (Bordeaux, Pessac, France)
Congress or journal article abstract
Congress or journal article abstract
PAH-specific therapies improve survival in patients with pulmonary arterial hypertension associated with connective tissue diseases: A Russian single centre experience
A. Volkov, N. Yudkina, E. Nikolaeva, I. Kurmukov (Moscow, Russian Federation)
Congress or journal article abstract
Congress or journal article abstract