ERS International Congress, Madrid 2019

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Citations should be made in the following way: Authors. Title. Eur Respir J 2019; 54: Suppl. 63, abstract number.

Mechanisms underlying acute exacerbation of respiratory disease

Symposium
Chairs: K. Bracke (Ghent, Belgium), T. Maher (St. Albans, United Kingdom), R. Chambers (London, United Kingdom)
Aims: to explain that exacerbations represent occasions of respiratory tract dysbiosis, leading to dysregulated host immune responses and a perpetuating cycle of inflammation and abnormal lung remodelling; to describe the differences in the composition of respiratory tract microbiota, and link these differences to the frequent-exacerbator phenotype and as drivers of inflammation, fibrosis and remodelling in the context of respiratory disease progression.

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Viruses as a critical trigger in the development of acute exacerbations of asthma S. Johnston (London, United Kingdom)
Role of necroptosis in the pathogenesis of COPD H. Van Eeckhoutte (Ghent, Belgium), F. Verhamme (Ghent, Belgium), Z. Lu (Newcastle, Barbados), T. Buyle-Huybrecht (Ghent, Belgium), G. Brusselle (Ghent, Belgium), P. Vandenabeele (Ghent, Belgium), T. Vandenberghe (Ghent, Belgium), M. Fricker (Newcastle, Barbados), P. Hansbro (Newcastle, Barbados), K. Bracke (Ghent, Belgium)
Harnessing the microbiome to combat inflammation: a hot topic or a credible future? J. MacSharry (Cork 1, Ireland)
Novel cellular effects of ultrafine particulate matter from an underground railway station revealed by RNA sequencing M. Loxham (Southampton, United Kingdom), J. Woo (Southampton, United Kingdom), A. Singhania (Southampton, United Kingdom), N. Smithers (Southampton, United Kingdom), A. Yeomans (Southampton, United Kingdom), G. Packham (Southampton, United Kingdom), A. Crainic (Southampton, United Kingdom), R. Cook (Southampton, United Kingdom), F. Cassee (Bilthoven, Netherlands), C. Woelk (Southampton, United Kingdom), D. Davies (Southampton, United Kingdom)
Development and homeostasis of a healthy microbiome in the human respiratory tract R. Dickson (Ann Arbor, United States of America)