Masao Takata (London, United Kingdom), Emma Rawlins (Cambridge, United Kingdom), Irene Heijink (Groningen, Netherlands)
LSC Abstract – The role of platelet-expressed C-type lectin-like receptor-2 in regulating the severity of murine lung injury
Sian Lax (Birmingham, United Kingdom), Sian Lax, Julie Rayes, David Thickett, Steve Watson
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LSC Abstract – Identification of distinct biological phenotypes of ARDS by cluster analysis and association with mortality
Lieuwe Bos (Amsterdam, Netherlands), Lieuwe Bos, Laura Schouten, Lonneke van Vught, Maryse Wiewel, David Ong, Olaf Cremer, Tom van der Poll, Janneke Horn, Nicole Juffermans, Marcus Schultz
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LSC Abstract – Vitamin D stimulates macrophage efferocytosis and encourages a proresolution phenotype
Dhruv Parekh (Birmingham, United Kingdom), Dhruv Parekh, Gavin Perkins, David Thickett
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Mesenchymal stromal cells (MSC) anti-microbial effect in acute respiratory distress syndrome (ARDS) is mediated in part by enhanced alveolar macrophage phagocytosis through cell contact-dependent mitochondrial transfer leading to improved macrophage bioenergetics
Megan Jackson (Belfast, United Kingdom), Megan Jackson, Thomas Morrison, Danny McAuley, Cecilia O’Kane, Michael Matthay, Anna Krasnodembskaya
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A mouse model of acute lung injury implicates phospholipase Cε in neutrophilic inflammation through CXC chemokine production
Kanoko Umezawa (Kobe, Japan), Kanoko Umezawa, Tatsuya Nagano, Hironori Edamatsu, Haruka Nshimura, Daisuke Tamura, Kazuyuki Kobayashi, Tohru Kataoka, Yoshihiro Nishimura
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ATP selectively packages TNF within microvesicles released from alveolar macrophages
Sanooj Soni (London, United Kingdom), Sanooj Soni, Ying Ying Tan, Kahori Cho, Michael Wilson, Kieran O’dea, Masao Takata
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Neutrophil extracellular traps are pathogenic in ventilator-induced lung injury and its formation is dependent on TLR4 signaling
Haosi Li (Changsha, China), Haosi Li, Pinhua Pan
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Proton-sensing TDAG8 exhibits the protective role in lipopolysaccharide-induced acute lung injury
Hiroaki Tsurumaki (Maebashi, Japan), Hiroaki Tsurumaki, Takeshi Hisada, Chihiro Mogi, Haruka Saito-Aoki, Masakiyo Yatomi, Yousuke Kamide, Masayuki Tobo, Koichi Sato, Yasuhiko Koga, Akihiro Ono, Kunio Dobashi, Tamotsu Ishizuka, Masanobu Yamada, Fumikazu Okajima
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Oxidative stress in TGF-β1-mediated fibrosis in Z alpha-1 antitrypsin cells
Samuel Alam (Cambridge, United Kingdom), Samuel Alam, Ravi Mahadeva
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Cell therapy for the treatment of acute lung injury: Alveolar type II cells or mesenchymal stem cells?
Raquel Guillamat-Prats (Barcelona, Spain), Raquel Guillamat-Prats, Marta Camprubí-Rimblas, Ferranda Puig, Raquel Herrero, Anna Serrano-Mollar, Jessica Tijero, Maria Nieves Gómez, Lluís Blanch, Antonio Artigas
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Aquaporin levels in murine lung injury
Alice Vassiliou (Athens, Greece), Alice Vassiliou, Nikolas Manitsopoulos, Matina Kardara, Nikoloas Maniatis, Stylianos Orfanos, Anastasia Kotanidou
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Effects of VAChT reduction on the time course of lung inflammation in mice with acute lung injury
Nathalia Pinheiro (Sao Paulo, Brazil), Nathalia Pinheiro, Fernanda Santana, Luciana Caperuto, Iolanda Tiberio, Vania Prado, Marco Antonio Prado, Milton Martins, Carla Prado
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Leukotriene E4 affects expression of genes involved in inflammatory, remodelling and mitogenic responses in human bronchial epithelial cells
Siiri Altraja (Tartu, Estonia), Siiri Altraja, Mario Mitt, Alan Altraja
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Cigarette smoke alters primary human bronchial epithelial cell (PBEC) differentiation at air-liquid interface (ALI) and induces expression of CD105 and CD146
Rosalia Gagliardo (Palermo, Italy), Rosalia Gagliardo, Fabio Bucchieri, Giusy Daniela Albano, Angela Marina Montalbano, Roberto Marchese, Giulia Anzalone, Alberto Fucarino, Giuseppe Paglino, Chiara Lo Nigro, Pascal Chanez, Mirella Profita
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Is there a secondary defect in CFTR in the nasal epithelium of patients with primary ciliary dyskinesia?
Katharine Harman (Melbourne, Australia), Suzanne Crowley, Michael Waller, Eric Alton, Jane Davies
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LSC Abstract – Unsupervised gene co-expression analysis identifies a novel endotype in severe asthma
Akul Singhania (Southampton, United Kingdom), Akul Singhania, Laurie C.K. Lau, Hitasha Rupani, Nivenka Jayasekera, Hans Michael Haitchi, Christopher H. Woelk, Peter H. Howarth
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LSC Abstract – System biology of adrenomedullin is controlled via its cell type specific expressed receptors in the human lung
Jyotshna Mandal (Basel, Switzerland), Jyotshna Mandal, Michael Roth, Eleni Papakonstantinou, Lukas Bubendorf, Spasenija Savic, Michael Tamm, Daiana Stolz
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TGFβ-induced epithelial to mesenchymal transition (EMT) as a model of COPD
Jo-Maree Courtney (Hobart, Australia), Jo-Maree Courtney, Patricia Spafford, Sukhwinder Singh Sohal, E. Haydn Walters
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Lung ageing in C57/Bl6 and BALB/c mice is characterized by a defective surfactant metabolism, increased ER stress and inflammasome induction
Martina Korfei (Giessen, Germany), Martina Korfei, David Klaus, Daniel Stelmaszek, Clemens Ruppert, Ingrid Henneke, Werner Seeger, Andreas Guenther
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Primary ciliary dyskinesia caused by loss-of-function GAS8 mutations due to defects of the nexin-dynein regulatory complex
Johanna Raidt (Münster, Germany), Johanna Raidt, Claudius Werner, Heike Olbrich, Niki T. Loges, Julia Wallmeier, Petra Pennekamp, Christine Edelbusch, Oliver Schwartz, Gerard W. Dougherty, Carolin Cremers, Kim G. Nielsen, June K. Marthin, Maria Philipsen, Holger Thiele, Janine Altmüller, Frank Rommelmann, Heymut Omran
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