K. F. Rabe (Leiden, The Netherlands), J. C. Kips (Ghent, Belgium)
Production of matrix metalloprotease-9 (MMP-9) by alveolar macrophages (AMs) from smokers: effect of corticosteroids and phosphodiesterase inhibition
N. Roche, S. Lim, B. G. Oliver, K. F. Chung (London, United Kingdom)
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The phosphodiesterase 4 inhibitor SB 207499 selectively inhibits neutrophil functions
G. P. Downey, E. Malus, V. Cherapanov, A. Arora, C. Loeve (Toronto, Canada)
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The novel phosphodiesterase 4 inhibitor CI-1044 inhibits in vitro LPS-induced TNFα production in whole blood of COPD patients
M. Ouagued, C. Martin-Chouly, C. Leportier, C. Belleguic, P. Delaval, V. Lagente, C. Danzin, C. Bertrand, M. P. Pruniaux (Fresnes, Rennes, France)
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First-dose bronchodilating effect of phosphodiesterase-4 (PDE-4) inhibition by cilomilast (Ariflo) with or without coadministration of salbutamol and/or ipratropium in COPD patients
D. C. Grootendorst, S. A. Gauw, J. Kelly, R. D. Murdoch, P. J. Sterk, K. F. Rabe (Leiden, The Netherlands; Harlow, United Kingdom)
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NIK-616, a new type of selective phosphodiesteraseIV(PDE IV) inhibitor with reduced emetic activity
K. Yamana, N. Suzuki, T. Ohtani, T. Machida, S. Ina (Omiya, Saitama, Japan)
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The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit
H. Jones, W. Paul, C. Page (London, United Kingdom)
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Inhibition by roflumilast of airway hyperresponsiveness to adenosine and pulmonary inflammation in allergen challenged Brown-Norway rats
L. Wollin, J. Barsig, D. S. Bundschuh, D. Marx, R. Beume (Konstanz, Germany)
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In vitro and in vivo anti-inflammatory activity of the novel PDE4 inhibitor roflumilast
D. S. Bundschuh, J. Barsig, R. Beume, M. Eltze, C. Schudt, L. Wollin, A. Hatzelmann (Konstanz, Germany)
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Efficacy of the PDE4 inhibitor, BAY 19-8004, in a smoke-induced model of pulmonary inflammation in the guinea pig
M. F. Fitzgerald, D. Spicer, H. Lisle, N. Bowyer, R. G. Sturton, D. Minshall, B. Meshi, D. Ionescu, M. T. Shrad, J. C. Hogg (Stoke Poges, United Kingdom; Vancouver, Canada)
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A selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in guinea-pig antigen challenge and ferret emesis models
M. F. Fitzgerald, B. A. Briggs, A. M. Thompson, D. F. Edwards, R. G. Sturton (Stoke Poges, United Kingdom)
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Molecular and cellular profile of the structurally novel phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004
R. G. Sturton, N. M. Butt, S. P. Palfai, S. R. Tudhope, T. S. Abram, R. Fischer, R. Henning, G. Braunlich, M. Es-Sayed (Stoke Poges, United Kingdom; Elberfield, Germany)
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The effect of an oral phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in primate asthma models
N. Fitch, M. S. Freeman, R. G. Sturton, P. Harris, D. Lindell, R. Gundel (Berkeley, United States Of America; Stoke Poges, United Kingdom)
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Efficacy of the selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in a rat model of neutrophilic lung inflammation
M. F. Fitzgerald, D. Spicer, E. Clark, N. Bowyer (Stoke Poges, United Kingdom)
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Effect of humanized monoclonal anti-IgE antibody, omalizumab, on allergen challenge-induced nasal response in subjects with allergic rhinitis and allergic asthma
G. Hanf, O. Noga, A. O'Connor, G. Kunkel (Berlin, Germany)
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Treatment with omalizumab (rhuMAb-E25), a monoclonal anti-IgE antibody induces effective changes in subjects with allergic asthma
O. Noga, G. Hanf, E. Kirchhof, C. Buettner, G. Kunkel (Berlin, Germany)
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Omalizumab, a novel therapy for severe allergic asthma
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Omalizumab, a recombinant humanized monoclonal anti-IgE antibody, decreases the risk of serious asthma exacerbations requiring hospitalization in patients with moderate-to-severe allergic asthma
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Omalizumab improves asthma-specific quality of life in patients with severe allergic asthma
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Omalizumab in the treatment of perennial allergic rhinitis
T. Casale, P. Chervinsky, W. Busse, A. Nayak, I. Tripathy, A. Fowler Taylor, N. Gupta, H. Shen (Omaha, North Dartmouth, Madison, Normal, Rolla, East Hanover, United States Of America)
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