Annual Congress Amsterdam 2011

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Maurizio Vignola Award for Innovation in Pneumology Ceremony (supported by Chiesi Foundation) followed by Science Year in Review

Session
Chairs: T. Geiser (Bern, Switzerland), P. J. Barnes (London, United Kingdom)
Aims: An update on important scientific developments that are of future clinical relevance.

Suggested references for the presentations.
"Inflammasomes in inflammatory lung disease":
- Dostert C, Petrilli V, Van Bruggen R, et al. Innate immune activation through Nalp3 inflammasome sensing of asbetstos and silica. Science 2008;320: 674-677.
- Yazdi AS, Guarda G, Riteau N, et al. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammsaome and cause pulmonary inflammation through relase of IL-1alpha and IL-1beta. Proc Natl Acad Sci USA 2010; 107: 19449-19454.
- Martinon F, Mayor A, Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol 2009; 27: 229-265.
- Henderson C, Goldback-Mansky R. Monogenic autoinflammatory diseases: new insights into clinical aspects and pathogenesis. Curr Opin Rheumatol 2010; 22: 567-578.
"Th17 cells in inflammatory lung diseases"
- Vanaudenaerde BM, Verleden SE, Vos R, et al. Innate and adaptive il-17 producing lymphocytes in chronic inflammatory lung disorders. Am J Respir Crit Care Med 2011; 183: 977-986.
- Di Stefano A, Caramori G, Gnemmi I, et al. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol 2009; 157: 316-324.
- Cua DJ, Tato CM. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010; 10: 479-489.
- Pene J, Chevalier S, Preisser L, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 2008; 180: 7423-7430.
"Towards an artificial lung":
- Ott HC, Clippinger B, Conrad C. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010; 16: 927-933.
- Ott HC, Matthiesen TS, Goh SK. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med 2008; 14: 213-221.
"TIM genes in allergic inflammation"
- Lin J, Kane LP. Are TIM proteins involved in asthma development or pathology? Clin Exp Allergy 2011; 41: 917-919.
- Sonar SS, Hsu YM, Conrad ML, et al. Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. J Clin Invest 2010; 16: 2767-2781.
- Wu QW, Cai PC, Wang L, et al. Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios. Int Arch Allergy Immunol 2009; 150: 252-260.
- Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, et al: The costimulatory role of TIM molecules. Immunol Rev 2009; 229: 259-270.

Towards an artificial lung L. Ikonomou (Boston, United States of America)
TIM genes in allergic inflammation H. Renz (Marburg, Germany)