BACKGROUND: Maternal cigarette smoking is associated with increased risks of growth and other problems. Smoking cessation in early pregnancy seems to reduce these risks.OBJECTIVE: comparative assessment of pregnancy smoking and nonsmoking women and newborn period infants.METHODS: 120 pregnant women were examined (39 of them have never smoked, 39 ex-smoked, 42 smoke), and infants in this three groups.Evaluated the clinical and laboratory parameters in women before and after delivery, histological examination of the placenta.In infants was studied neonatal adaptation in a maternity hospital, a comparative analysis of laboratory data, neurosonography.RESULTS The average age of respondents pregnant women in the group of smokers (S) was 24,5 ± 4,27, ex-smokes (ES) - 25,5 ± 3,07, nonsmokers(NS) - 26,8 ± 6,75.Smoking history in a group of S 7,43 ± 4,11 years, ES-5,92 ± 3,43 years. In S more frequent were hydramnios (15%), urogenital candidiasis -57% vs. 50% of ES and 8% NS. 93% of S have chronic intrauterine fetal hypoxia and fetoplacental insufficiency (ES- 38.5% and NS- 8%).Premature rupture of membranes is registered with 28% of S compared to 15% ES.At histopathological examination was found acute placental insufficiency in 8 cases (57%) among S and 3 cases (23%) in ES. Intranatal asphyxia was diagnosed in 42% of infants of S mothers and 15% of ES.At neurosonography is revealed cerebral ischemia I st in all newborns of S.Weight of infants born to S was 352g. lighter vs. to NS.CONCLUSIONS: Cigarette smoke is a significant risk factor for women and newborn; the negative effects of smoking can be significantly offset by through of recommendations for smoking cessation before pregnancy.