Introduction : Osteopontin is glucoprotein largely expressed in relation to malignant diseases of the lungs such as malignant mesothelioma among pulmonary asbestosis and has been reported to have differences in expression according to the finding of high resolution computed tomography (HRCT). However, relevant domestic reports are lacking. Methods : In an epidemiologic survey on residents near an asbestos mine in Chungcheongnam-do, the levels of osteoponin in 72 patients among 179 patients with pulmonary asbestosis were measured. Results : Among the 72 subjects, the number of males was 47 and their average age was 70.4±7.4 and their average period of exposure to asbestos was 59.0±16.2. The number of residents who worked at an asbestos mine or an asbestos factory was 34 (47%) and their average working period was 2.5±3.5 years. The osteopontin levels of asbestos patients were 13.8±7.4ng/ml and did not show significant difference from the healthy control group (n=8, 10.1±3.9 ng/ml, p =0.158). At the time of diagnosis of the patients, the findings of HRCT were compared among four different groups (an pulmonary asbestosis, a pleural plaques group, a group with pulmonary asbestosis and pleural plaques, and other asbestos disease group). The pulmonary asbestosis group had a high level of osteopontin, which was not statistically significantly different, however (n=3, 23.2±9.2 vs 13.4±7.1 ng/ml, p=0.203). Conclusion : Korea asbestos patients' levels of osteopontin did not significantly differ from those of the healthy control group and according to HRCT findings classification.