The immunodeficiency(ID) disorders increase the risk for infection and diseases with Mycobacterium tuberculosis (MT),delay the early diagnosis of tuberculosis (TB) and aggravate its evolution.Aim: Identifying the clinical,radiological,laboratory and treatment particularities of TB on patients with ID disorders aged between 0-18 years.Materials and methods: A retrospective study of 23 cases with TB and ID disorders admitted in the Pediatric Department, between 2003- 2013. We have analyzed: the demographic data, immunodeficiency type, clinical features,Mantoux skin test, localization of TB, aspects of TB on the chest radiography, laboratory findings, the treatment used and therapeutic outcome.Results:The average age was 10, 6 years, 3(13%) had primary IDand 20(86%) had secondary ID. Pulmonary TB was detected in 11(48%) cases, extra-pulmonary TB in 8(35%) cases and TB infection in 4(17%) cases, the diagnosis of ID preceded the diagnosis of TB in 17(74%) cases and diagnoses were simultaneous in 5(22 %) cases. Mantoux skin test was positive in 10(43%) cases.Respiratory symptoms were present in 14(61%) cases.Chest radiography was abnormal in 20 (87%) cases, MT was detected in 11(48%) cases and 13(57 %) cases required additional tests. Anti-tuberculosis treatment was applied in 19(83%) cases and simultaneous medication in 10(43%) cases.The success of the TB treatment was achieved only in 19(83%) cases.Conclusions. TB is likely to be underdiagnosed on patients with ID disorders. By using the additional tests for early diagnosis of both diseases and applying a prompt and adequate anti TB treatment, but also a specific treatment for treatable ID, the healing rate of tuberculosis is increased.