The aim of the study was to determine functional acoustic characteristics of breath by bronchophonographic method (BPG) in infants with wheezing.
Methods: We observed 24 children (2 month-3 years) with wheezing. The patients were divided into two groups (Gr), the Gr1 (n=14) - atopic children and Gr2 (n=10) - non-atopic children. The control group (C) included 27 healthy non-atopic children (2 month - 3 years of age). Computerized BPG by computer diagnostic complex «Pattern» (MEI, Russia) (0,2-12,6 kHz) before and after inhalation of salbutamol (BTS) was provided all patients after the disappearance of wheezing. It were used coefficients of the general acoustic breath work (ABW) – φ1 (0,2-1,2 kHz), φ2 (1,2-5,0 kHz), φ3 (5,0-12,6 kHz), representing relation of level ABW in a given frequency range of the level general ABW.
Results. There were significantly more high parameters of general ABW, φ2, φ3 in the patients of Gr1 and Gr2 in comparison with Gr3 (p<0,05). Patients of Gr1 showed more high general ABW then Gr2 (p1-2 <0,01). The patients of Gr1 and Gr2 also showed the most high amplitude of sounds in high frequency zone (5,0-12,6 kHz) in comparison with Gr3 (p<0,05). After BTS for the most part of children of the Gr1 (2/3) and 1/2 of the Gr2 showed significant decreasing φ3; the level of φ3 in the Gr1 decreased significantly more in comparison with Gr2 (accordingly 64,4±7,7%; 40,0±10,3%; p<0,05).
Conclusion: These preliminary results showed that the infants after the disappearance of wheezing still demonstrate the significant functional acoustic disorders. It was more expressed at atopic children then non-atopic. It can be important in relation of early debut of bronchial asthma.