Abstract
Introduction: We investigated levels of microalbuminuria and the factors determining in patient with COPD
Method: 66 patients with COPD and 40 subjects as control group were included. The presence of microalbuminuria (MAB) was defined when the urinary albumin creatinin ratio (UACR) was between 20 mg/g in men and 30 m/g in women.
Results: Pearson correlation showed that there were inverse associations between UACR and PO2, FEV1%, FVC% and positive relation between UACR and BODE index. In linear regression model, the UARC showed inverse association with PO2 while positive association with MRCI, and BODE index.

Table 1: The predictors of urinary albumin/kreatinin ratio in all subjects
Urinary albumin/kreatinin ratioB valuesp valuesUrinary albumin/kreatininB valuesp valuesUrinary albumin/kreatininB values p values
Age-0.100.4Age-0.180.17Age0.01 0.9
Sex0.170.1Sex-0.010.9Sex0.05 0.06
BMI-0.020.8BMI0.220.07BMI-0.06 0.6
MRCI0.310.007MRCI0.040.04MRCI0.19 0.1
PO2-0.220.04FEV1 %-0.120.3BODE index0.28 0.01
Statistical significance p<0.05 BMI: Body Mass Index MRCIS: The Modified Cumulative Illness Rating Scale


In logistic regression model, the presence of MAB showed associations with severity of COPD, PO2, BODE index, PO2 and age.

Table 2 : The predictors of presence of MAB in all subjects
 Presence of MAB Presence of MAB Presence of MAB
 p values p values p values
Age0.003Age0.02Age0.007
Sex0.4Sex0.3Sex0.3
Smoke p/y0.7Smoke p/y0.9Smoke p/y0.7
Severity of COPD0.04BODE index0.02PO20.003
Statistical significance p<0.05 BMI: Body mass index COPD: Chronic obstructive pulmonary disease


Conclusion: Microalbuminüria may be seen in patints with COPD depending on severity of disease and hypoxemia.