Intrapleural instillation of streptokinase is an accepted form of treatment for loculated pleural effusion, but it has not been consistently proven to be effective. This study aims to determine the effectiveness of streptokinase in treating loculated pleural effusion; to compare the outcomes of patients treated with streptokinase and those who are not; and to identify the clinical characteristics of patients who developed loculated pleural effusion.
This is a cohort, retrospective and descriptive study conducted at Cardinal Santos Medical Center (CSMC). Data analysis was done using the two-tailed ANOVA for length of hospital days and Pearson‘s Chi Square for morbidity and mortality. All patients who had loculated pleural effusion admitted at CSMC from January 2006 to October 2007 were included. Chest ultrasound results and medical charts of selected patients were reviewed. The study consisted of 19 subjects, 5 in the treatment group, and 14 in the control group. All patients underwent either CTT insertion, pigtail insertion or thoracentesis. Streptokinase differs in the dosage and frequency of administration. Mean age of participants is 51 years old. There are more male than female participants. Comorbidities and probable causes of pleural effusion such pneumonia, malignancy, tuberculosis and trauma were noted. The average amount of loculated pleural effusion is 590cc. In this study, the use of streptokinase in loculated pleural effusion decreases the number of hospital days, but found to be not significant in both morbidity and mortality.