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 European Respiratory Journal (ERJ) - Archive

February (Issue 2 Volume 37)
406
Steroids induce a disequilibrium of secreted interleukin-1 receptor antagonist and interleukin-1? synthesis by human neutrophils
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Langereis J.D., Oudijk E-J.D., Schweizer R.C., Lammers J-W.J., Koenderman L., Ulfman L.H.
Eur Respir J 2011; 37: 406		Full textPDF-fileAbstract

Abstract
Chronic obstructive pulmonary disease (COPD) is characterised by neutrophilic inflammation in the airways and these neutrophils contribute to the production of inflammatory mediators. Dampening the production of proinflammatory mediators might be an important strategy to treat COPD and glucocorticosteroids are known to do so via inhibition of nuclear factor-?B. However, this pathway is important for the control of pro- and anti-inflammatory genes. We studied the effects of dexamethasone on pro... [View all]
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