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 European Respiratory Journal (ERJ) - Archive

February (Issue 2 Volume 37)
331
Osteopontin expression and relation to disease severity in human asthma
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Samitas K., Zervas E., Vittorakis S., Semitekolou M., Alissafi T., Bossios A., Gogos H., Economidou E., Lötvall J., Xanthou G., Panoutsakopoulou V., Gaga M.
Eur Respir J 2011; 37: 331		Full textPDF-fileAbstract

Abstract
Recent studies have associated osteopontin (OPN) with allergic inflammation; however, its role in human asthma remains unclear. The aim of this study was to measure OPN levels in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of healthy controls and asthmatics, identify cellular sources of OPN and examine possible correlations between OPN expression, disease severity and airway remodelling. Serum samples were obtained from 35 mild-to-moderate asthmatics, 19 severe asthmatic... [View all]
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