European Respiratory Journal (ERJ) - Archive
| February (Issue 2 Volume 37) |  |
| Candidate genes for COPD in two large data sets
Bakke P.S., Zhu G., Gulsvik A., Kong X., Agusti A.G.N., Calverley P.M.A., Donner C.F., Levy R.D., Make B.J., Paré P.D., Rennard S.I., Vestbo J., Wouters E.F.M., Anderson W., Lomas D.A., Silverman E.K., Pillai S.G.
Eur Respir J 2011; 37: 255 |  |  |  | | | | | | | | |
Abstract| Lack of reproducibility of findings has been a criticism of genetic association studies on complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected 257 polymorphisms of 16 genes with reported or potential relationships to COPD and genotyped these variants in a case–control study that included 953 COPD cases and 956 control subjects. We explored the association of these polymorphisms to three COPD phenotypes: a COPD binary phenotype and two quantitative traits (post-br... [View all] |
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