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 European Respiratory Journal (ERJ) - Archive

February (Issue 2 Volume 37)
244
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways
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Cortijo J., Mata M., Milara J., Donet E., Gavaldà A., Miralpeix M., Morcillo E.J.
Eur Respir J 2011; 37: 244		Full textPDF-fileAbstract

Abstract
Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect of aclidinium, a new long-acting muscarinic antagonist, on MUC5AC expression in human airway epithelial cells. MUC5AC mRNA (RT-PCR) and protein expression (ELISA and immunohistochemistry) were studied in human bronchial tissue and differentiated human airway epithelial cells activated with carbachol (100 ?M) or cigarette smoke... [View all]
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