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 European Respiratory Journal (ERJ) - Archive

August (Issue 2 Volume 36)
348
Strong purified protein derivative responses are associated with poor mycobacterium inhibition in latent TB
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Kang J.S.L., Cherian A., Gan S.H., Lee T.H., Lee K.C., Chee C.B.E., Doherty T.M., Wang Y.T., Seah G.T.
Eur Respir J 2010; 36: 348		Full textPDF-fileAbstract

Abstract
The tuberculin skin test (TST) using purified protein derivative (PPD) of Mycobacterium tuberculosis is traditionally used to diagnose latent tuberculosis (TB) infection (LTBI). However, LTBI diagnosis by peripheral blood mononuclear cell (PBMC) interferon (IFN)-? responses to M. tuberculosis-specific antigens, early secreted antigenic target 6 kDa (ESAT-6) and culture filtrate protein (CFP)-10 has greater specificity. We investigated the difference in antimycobacterium cellular immunity in TB c... [View all]
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